ERBB2

Gene Information
Official Symbol
ERBB2
Officical Full Name
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
Primary Source
HGNC:3430
See related
MIM:164870 Ensembl:ENSG00000141736 HPRD:01281 Vega:OTTHUMG00000179300
Chromosome Location
17q12
Gene Type
protein-coding
Also known as
CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
External Sources
GUDMAP
Gene Expression by Disease State
# Acc. Type Year Sample Cnt. Sample Grouping
1 RGED30718 Microarray 2012 47 A Nephrectomy
B pristine protocol biopsy
C Acute kidney injury
2 RGED23911 Microarray 2011 6 A ALDH low cells
B ALDH high cells
# Acc. Type Year Sample Cnt. Sample Grouping
1 RGED7869 Microarray 2009 21 A Renal cyst from PKD1 patient, pooled from 4 different small cysts
B Renal cyst from PKD1 patient, medium single cyst
C Renal cyst from PKD1 patient, large single cyst
D Minimally cystic tissue from PKD1 patient
E Non-cancerous renal cortical tissue from nephrectomized kidney with isolated renal cell carcinoma of patient
# Acc. Type Year Sample Cnt. Sample Grouping
1 RGED41030 Microarray 2013 6 A fibroblast_control
B fibroblast_uremic
2 RGED43484 Microarray 2013 6 A Healthy Monocyte
B Uremic Monocyte
3 RGED53336 Microarray 2013 9 A PBMCs vs. PBMCs treated with TNF-a from 10 pooled healthy donors
B PBMCs vs. PBMCs treated with EPO-a from 10 pooled healthy donors
C PBMCs vs. PBMCs treated with TNF-a and EPO-a from 10 pooled healthy donors
4 RGED37171 Microarray 2012 115 A healthy volunteer whole blood (WB)
B pre-transplant uremic whole blood (WB)
5 RGED11227 Microarray 2008 16 A Blood sample from patient before NHD treatment
B Blood sample from patient after NHD treatment
# Acc. Type Year Sample Cnt. Sample Grouping
1 RGED46897 Microarray 2013 6 A treated with: serum from patients without diabetes (C) for 24hr
B treated with: serum from patients with diabetes and without kidney disease (DKD-) for 24hr
C treated with: serum from patients with diabetes and kidney disease (DKD+) for 24hr
2 RGED46899 Microarray 2013 6 A treated with: serum from patients without diabetes (C) for 24hr
B treated with: serum from patients with diabetes and without kidney disease (DKD-) for 24hr
C treated with: serum from patients with diabetes and kidney disease (DKD+) for 24hr
3 RGED30566 Microarray 2011 25 A Tubuli of control kidney
B Glomerulus of control kidney
4 RGED30528 Microarray 2011 22 A Glomerulus of control kidney
B Glomerulus of Diabetic Human Kidney
5 RGED30529 Microarray 2011 22 A Tubuli of control kidney
B Tubuli of Diabetic Human Kidney
6 RGED23338 Microarray 2011 9 A HK-2 cells, 0hrs
B HK-2 cells, 24hrs
C HK-2 cells, 48hrs
7 RGED20247 Microarray 2010 18 A Control_18hrs
B Control_48hrs
C C-peptide_18hrs
D TGF-beta_48hrs
E C-peptide_48hrs
F TGF-beta_C-peptide_48hrs
8 RGED1009 Microarray 2004 6 A Control
B Diabetes
# Acc. Type Year Sample Cnt. Sample Grouping
1 RGED35487 Microarray 2012 31 A Kidney biopsy from human IgAN
B Kidney biopsy from human pre-transplant living donor
2 RGED35488 Microarray 2012 31 A Tubulointerstitium from IgAN patient
B Tubulointerstitium from control living donor
3 RGED27676 Microarray 2012 6 A IgAN Patient with a Nomal Renal Function and microscopic hematuria
B IgAN Patient with a Nomal Renal Function and macroscopic hematuria
# Acc. Type Year Sample Cnt. Sample Grouping
1 RGED53757 Microarray 2014 144 A normal match to Stage 1 ccRCC
B Stage 1 ccRCC
C normal match to Stage 2 ccRCC
D Stage 2 ccRCC
E normal match to Stage 3 ccRCC
F Stage 3 ccRCC
G normal match to Stage 4 ccRCC
H Stage 4 ccRCC
2 RGED46699 Microarray 2014 130 A tissue: normal
B tissue: tumor
3 RGED36957 Microarray 2013 31 A disease status: renal cell carcinoma/cesd16 status: 0
B disease status: renal cell carcinoma/cesd16 status: 1
4 RGED40435 Microarray 2013 202 A ccRCC tumour tissue
B adjacent non-tumour renal tissue
5 RGED47352 Microarray 2013 9 A non-metastatic ccRCC
B primary metastatic ccRCC
6 RGED51627 Microarray 2013 6 A Untreated control, A-498
B 1000µM zebularine, A-498, biological rep 3
7 RGED24455 RNA-seq 2013 20 A kidney normal tissue
B kidney cancer tissue
8 RGED32297 Microarray 2012 6 A cell line: 786-M1A cell line (metastatic) protocol: control
B cell line: 786-M1A cell line (metastatic) protocol: HA-VHL reintroduced
9 RGED32298 Microarray 2012 6 A cell ine: 786-O renal cell carcinoma cell line agent: control
B cell ine: 786-O renal cell carcinoma cell line agent: 5-aza-deoxycytidine
10 RGED35417 Microarray 2012 7 A cell line: 786-O renal cell carcinoma cell line /tranduced with: pGIPZ control vector
B cell line: 786-O renal cell carcinoma cell line /tranduced with: SUZ12sh1
11 RGED37616 RNA-seq 2012 33 A tissue: non-tumoral renal cortex
B tissue: clear cell renal cell carcinoma
12 RGED29609 Microarray 2011 39 A Clear-cell renal cell carcinoma
13 RGED33371 Microarray 2011 65 A Normal Adrenal Cortex
B Adrenocortical Adenoma
C Adrenocortical Carcinoma
14 RGED26574 Microarray 2011 67 A disease state: normal_tissue
B disease state: ccRCC
C disease state: Chromophobe
D disease state: HLRCC
E disease state: Pap_type1
F disease state: Pap_type2
15 RGED20896 Microarray 2010 6 A tissue: normal
B tissue: tumor
16 RGED21816 Microarray 2010 18 A disease state: control (normal kidney)
B disease state: BHD renal tumor
17 RGED23627 Microarray 2010 5 A RCC parental cell line (non-metastatic)
B RCC Lung metastatic
18 RGED19982 Microarray 2010 30 A Chromophobe RCC tumor tissue
B Oncocytoma tissue
19 RGED23629 Microarray 2010 32 A Primary RCC tumor
B Metastatic RCC tumor
20 RGED20491 Microarray 2010 67 A treatment: None
B treatment: emetine
C treatment: Caffeine
21 RGED22541 Microarray 2010 48 A primary clear-cell renal cell carcinoma
B pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)
22 RGED22563 Microarray 2010 22 A RCC Cell line control
B RCC Cell line 5-Aza-2-deoxycytidine treated
23 RGED10320 Microarray 2009 144 A Pretreatment tumor tissue: Non-relapse
B Pretreatment tumor tissue: Relapse
24 RGED10927 Microarray 2009 65 A Normal Adrenal Cortex
B Adrenocortical Adenoma
C Adrenocortical Carcinoma
25 RGED12114 Microarray 2009 27 A mRNA from Renal Clear Cell Carcinoma
26 RGED14762 Microarray 2009 22 A disease state: Normal
B disease state: clear cell renal cell carcinoma
27 RGED14378 Microarray 2009 20 A pulmonary metastasis of clear-cell renal cell carcinoma (laser resection) Gender: Female
B pulmonary metastasis of clear-cell renal cell carcinoma (laser resection) Gender: Male
28 RGED15641 Microarray 2009 92 A normal human kidney tissue
B cancerous human kidney tissue, clear cell RCC
C cancerous human kidney tissue, papillary RCC
D cancerous human kidney tissue, transitional cell carcinoma
E cancerous human kidney tissue, chromophobe RCC
F cancerous human kidney tissue, oncocytoma
29 RGED11024 Microarray 2008 79 A Normal kidney
B Renal Tumor
30 RGED11151 Microarray 2008 67 A normal kidney
B renal tumor
31 RGED11904 Microarray 2008 21 A VHL: WT HIF: Negative
B VHL: Deficiant HIF: HIF-2
C VHL: Deficiant HIF: HIF-1 + HIF- 2
32 RGED11985 Microarray 2008 12 A mRNA from Renal Clear Cell Carcinoma
33 RGED12090 Microarray 2008 18 A Chromophobe
B Oncocytoma
34 RGED12606 Microarray 2008 10 A normal kidney tissue
B clear cell renal cell carcinoma
C metastasis clear cell renal cell carcinoma
35 RGED8289 Microarray 2008 8 A HEK293 cell line with noninduced HNF4a2
B HEK293 cell line with induced HNF4a2
36 RGED7023 Microarray 2007 47 A subtype: NO
B subtype: P1
C subtype: P1.2A
D subtype: P2A
E subtype: P2B
37 RGED2712 Microarray 2005 35 A fetal kidney samples
B Clear cell sarcoma of the kidney
C Wilms tumors
38 RGED2700 Microarray 2005 8 A HEK293 cell line with noninduced HNF4a2
B HEK293 cell line with induced HNF4a2
39 RGED2748 Microarray 2005 34 A Papillary RCC Sample Histo: 1
B Papillary RCC Sample Histo: 2A
C Papillary RCC Sample Histo: 2B
# Acc. Type Year Sample Cnt. Sample Grouping
1 RGED46474 Microarray 2014 40 A Acute Rejection
B Non-Rejection
2 RGED34437 Microarray 2014 66 A disease status: acute renal allograft rejection, ARIA
B disease status: borderline acute renal allograft rejection
C disease status: no significant abnormalities
D disease status: baseline, living donor
3 RGED43974 Microarray 2014 554 A Kidney_donor_BD
B Kidney_donor_DCD
C Kidney_donor_Living
4 RGED15296 Microarray 2014 75 A Acute Kidney Rejection
B Well-functioning kidney transplant
5 RGED48581 Microarray 2013 306 A tissue: renal allograft biopsy diagnosis: ABMR
B tissue: renal allograft biopsy diagnosis: mixed
C tissue: nephrectomy
D tissue: renal allograft biopsy diagnosis: non-rejecting
E tissue: renal allograft biopsy diagnosis: TCMR
6 RGED36059 Microarray 2013 411 A renal allograft biopsy /diagnosis: ABMR
B renal allograft biopsy /diagnosis: MIXED
C nephrectomy /diagnosis: Nephrectomy
D renal allograft biopsy /diagnosis: non-rejecting
E renal allograft biopsy /diagnosis: TCMR
7 RGED37838 Microarray 2013 78 A tissue: nephrectomy /diagnosis (good,bad): nephrectomy
B tissue: renal allograft biopsy /diagnosis (good,bad): good
C tissue: renal allograft biopsy /diagnosis (good,bad): bad
8 RGED47097 Microarray 2013 40 A Control
B Acute renal allograft rejection - Steroid responsive
C Acute renal allograft rejection - Steroid resistant
9 RGED50058 Microarray 2013 101 A renal allograft biopsy_stable patient
B renal allograft biopsy_patient with acute rejection
10 RGED52694 Microarray 2013 28 A stable renal graft function_≤2 months
B deteriorated renal graft function_≤2 months
C stable renal graft function time after transplantation: 3 months
D deteriorated renal graft functiontime after transplantation: 3 months
11 RGED14346 Microarray 2012 75 A Peripheral Blood from kidney transplant recipients Disease State: Acute Rejection
B Peripheral Blood from kidney transplant recipients Disease State: Stable
12 RGED41485 Microarray 2012 8 A ccRCC cells treated with DMSO for 24H
B ccRCC cells treated with A939572 for 24H
13 RGED25902 Microarray 2011 120 A Baseline (0 months) - Non-progressive CADI score
B Baseline (0 months) - Progressive CADI score
C 6 months - Non-progressive CADI score
D 6 months - Progressive CADI score
E Discovery set low CADI score
F Discovery set high CADI score
G Post-transplant rejection
H 24 months low CADI score
I 24 months high CADI score
14 RGED12682 Microarray 2010 52 A Healthy glomeruli
B Healthy tubulointerstitium
C Diseased tubulointerstitium
15 RGED14328 Microarray 2010 36 A kidney allograft biopsy, stable
B kidney allograft biopsy, acute rejection
16 RGED22229 Microarray 2010 58 A phenotype: Healthy Control
B phenotype: Tolerant
C phenotype: Standard Immunotherapy
17 RGED22459 Microarray 2010 65 A histology: 1yr protocol bx - Banff: i/cg/ci=0
B histology: 1yr protocol bx - Banff: i/cg=0; ci>0
C histology: 1yr protocol bx - Banff: cg=0; i/ci>0
18 RGED14630 Microarray 2010 10 A Stable renal transplant recipients, T0 (time of enrollment)
B Stable renal transplant recipients, T1 (3 months after the switching of the therapy)
19 RGED20300 Microarray 2010 24 A transplant state: Acute Rejection
B transplant state: Stable
20 RGED21785 Microarray 2010 12 A Transplant Living Donor, microdissected Tubulus from kidney biopsy
B Transplant Living Donor, microdissected Glomerulus from kidney biopsy
21 RGED19130 Microarray 2009 119 A state: acute rejection
B state: acute tubular necrosis
C state: borderline change
D state: non-rejection
E state: presumed rejection
F state: renal recipients with stable function
22 RGED12187 Microarray 2009 77 A PBMC|Drug Regime: CNI [Calcineurin Inhibitor (Cyclosporine)]
B Whole Blood|Drug Regime: FK506 [Tacrolimus]
C PBMC|Drug Regime: Rapa [Drug Regime: Rapamycin]
23 RGED10419 Microarray 2008 29 A kidney sample from DCD donor (1 hr after reperfusion)
B kidney sample from LD donor (1 hr after reperfusion)
24 RGED11166 Microarray 2008 95 A kidney allograft biopsy, baseline, living donor
B kidney allograft biopsy, baseline, deceased donor
C kidney allograft biopsy, 3 months, living donor
D kidney allograft biopsy, 3 months, deceased donor
E kidney allograft biopsy, 6 months, living donor
F kidney allograft biopsy, 6 months, deceased donor
G kidney allograft biopsy, 12 months, living donor
H kidney allograft biopsy, 12 months, deceased donor
I kidney allograft biopsy, 24 months, living donor
J kidney allograft biopsy, 24 months, deceased donor
25 RGED7392 Microarray 2007 30 A Normal
B Subclinical interstitial fibrosis
26 RGED3297 Microarray 2005 12 A Control
B Laparoscopic Donor
27 RGED1563 Microarray 2004 62 A control healthy blood donor
B control healthy donor kidney
C Clinical status: PBL sample from transplant patient with renal dysfunction without rejection
D Clinical status: PBL sample from patient with well-functioning transplant with no clinical evidence of rejection
E Clinical status: PBL sample from transplant patient with kidney undergoing acute rejection
F Clinical status: sample from well-functioning transplant with no clinical evidence of rejection
G Clinical status: sample from transplant patient with kidney undergoing acute rejection
H Clinical status: sample from transplant with renal dysfunction without rejection
28 RGED1743 Microarray 2004 41 A BIOPSY FROM A HUMAN KIDNEY WITH A CYCLOSPORINE IMMUNOSUPPRESSIVE REGIMEN
B BIOPSY FROM A HUMAN KIDNEY WITH A SIROLIMUS (RAPAMYCIN) IMMUNOSUPPRESSIVE REGIMEN
# Acc. Type Year Sample Cnt. Sample Grouping
1 RGED32591 Microarray 2012 93 A Tubulointerstitium from control living donor
B Tubulointerstitium from LN patient
C Glomeruli from control living donor
D Glomeruli from LN patient
# Acc. Type Year Sample Cnt. Sample Grouping
1 RGED20602 Microarray 2010 18 A kidney biopsy from patient with NSC
B kidney biopsy from patient after Tumor Nephrectomy