NOTCH1 Expression Profiles in Kidney Transplantation

Tool Box: Similarity Analysis

Select from the Gene Set

  •   41bb pathway[18]
  •   Ace2 pathway[14]
  •   Ach pathway[17]
  •   Actiny pathway[21]
  •   Agpcr pathway[14]
  •   Agr pathway[37]
  •   Ahsp pathway[14]
  •   Akap13 pathway[13]
  •   Akap95 pathway[13]
  •   Akapcentrosome pathway[16]
  •   Akt pathway[23]
  •   Alk pathway[38]
  •   Ami pathway[21]
  •   Arap pathway[19]
  •   Arenrf2 pathway[14]
  •   Arf pathway[18]
  •   Asbcell pathway[13]
  •   At1r pathway[37]
  •   Atm pathway[21]
  •   Atrbrca pathway[22]
  •   Bad pathway[27]
  •   Barr mapk pathway[13]
  •   Barrestin pathway[11]
  •   Barrestin src pathway[16]
  •   Bcellsurvival pathway[17]
  •   Bcr pathway[38]
  •   Biopeptides pathway[46]
  •   Blymphocyte pathway[12]
  •   Cacam pathway[17]
  •   Calcineurin pathway[22]
  •   Cardiacegf pathway[19]
  •   Carm er pathway[36]
  •   Carm1 pathway[14]
  •   Caspase pathway[24]
  •   Cbl pathway[14]
  •   Ccr3 pathway[24]
  •   Ccr5 pathway[21]
  •   Cd40 pathway[16]
  •   Cdc42rac pathway[17]
  •   Cdk5 pathway[12]
  •   Cdmac pathway[17]
  •   Cell2cell pathway[15]
  •   Cellcycle pathway[24]
  •   Ceramide pathway[23]
  •   Cftr pathway[13]
  •   Chemical pathway[23]
  •   Chrebp2 pathway[43]
  •   Ck1 pathway[18]
  •   Classic pathway[15]
  •   Comp pathway[20]
  •   Creb pathway[28]
  •   Csk pathway[25]
  •   Ctcf pathway[24]
  •   Ctl pathway[16]
  •   Ctla4 pathway[22]
  •   Cxcr4 pathway[25]
  •   Cytokine pathway[23]
  •   D4gdi pathway[14]
  •   Dc pathway[23]
  •   Death pathway[34]
  •   Dnafragment pathway[11]
  •   Dream pathway[15]
  •   Ecm pathway[25]
  •   Edg1 pathway[28]
  •   Egf pathway[32]
  •   Egfr smrte pathway[12]
  •   Eif pathway[17]
  •   Eif2 pathway[12]
  •   Eif4 pathway[25]
  •   Epha4 pathway[11]
  •   Epo pathway[20]
  •   Eponfkb pathway[12]
  •   Erk pathway[29]
  •   Erk5 pathway[19]
  •   Eryth pathway[16]
  •   Etc pathway[13]
  •   Ets pathway[19]
  •   Extrinsic pathway[14]
  •   Fas pathway[31]
  •   Fcer1 pathway[42]
  •   Feeder pathway[10]
  •   Fibrinolysis pathway[13]
  •   Fmlp pathway[40]
  •   Free pathway[11]
  •   G1 pathway[29]
  •   G2 pathway[25]
  •   Gaba pathway[11]
  •   Gata3 pathway[17]
  •   Gcr pathway[23]
  •   Gh pathway[29]
  •   Gleevec pathway[24]
  •   Glycolysis pathway[11]
  •   Gpcr pathway[38]
  •   Granulocytes pathway[15]
  •   Gsk3 pathway[28]
  •   Hcmv pathway[18]
  •   Hdac pathway[33]
  •   Her2 pathway[23]
  •   Hif pathway[16]
  •   Hivnef pathway[59]
  •   Hsp27 pathway[16]
  •   Igf1 pathway[22]
  •   Igf1mtor pathway[21]
  •   Igf1r pathway[24]
  •   Il10 pathway[18]
  •   Il12 pathway[24]
  •   Il17 pathway[18]
  •   Il1r pathway[34]
  •   Il2 pathway[23]
  •   Il22bp pathway[17]
  •   Il2rb pathway[39]
  •   Il3 pathway[16]
  •   Il4 pathway[12]
  •   Il5 pathway[11]
  •   Il6 pathway[23]
  •   Il7 pathway[18]
  •   Inflam pathway[30]
  •   Insulin pathway[23]
  •   Integrin pathway[39]
  •   Intrinsic pathway[24]
  •   Keratinocyte pathway[47]
  •   Kreb pathway[9]
  •   Lair pathway[18]
  •   Lectin pathway[13]
  •   Leptin pathway[12]
  •   Longevity pathway[16]
  •   Lym pathway[12]
  •   Mal pathway[20]
  •   Mapk pathway[88]
  •   Mcalpain pathway[26]
  •   Mcm pathway[19]
  •   Mef2d pathway[24]
  •   Met pathway[38]
  •   Mitochondria pathway[22]
  •   Monocyte pathway[12]
  •   Mpr pathway[35]
  •   Mta3 pathway[20]
  •   Mtor pathway[24]
  •   Myosin pathway[32]
  •   Ndkdynamin pathway[22]
  •   Neurotransmitters pathway[7]
  •   Nfat pathway[57]
  •   Nfkb pathway[24]
  •   Ngf pathway[19]
  •   Nkcells pathway[21]
  •   Nkt pathway[30]
  •   No1 pathway[34]
  •   No2il12 pathway[18]
  •   Nos1 pathway[25]
  •   Nthi pathway[25]
  •   Nuclearrs pathway[16]
  •   P27 pathway[14]
  •   P35alzheimers pathway[12]
  •   P38mapk pathway[41]
  •   P53 pathway[17]
  •   P53hypoxia pathway[24]
  •   Par1 pathway[38]
  •   Parkin pathway[14]
  •   Pdgf pathway[33]
  •   Pgc1a pathway[27]
  •   Pitx2 pathway[16]
  •   Plateletapp pathway[15]
  •   Plce pathway[13]
  •   Pml pathway[18]
  •   Ppara pathway[59]
  •   Proteasome pathway[29]
  •   Ps1 pathway[15]
  •   Ptc1 pathway[12]
  •   Ptdins pathway[24]
  •   Pten pathway[19]
  •   Pyk2 pathway[32]
  •   Rab pathway[13]
  •   Rac1 pathway[24]
  •   Raccycd pathway[27]
  •   Rankl pathway[15]
  •   Ranms pathway[11]
  •   Rarrxr pathway[16]
  •   Ras pathway[24]
  •   Rb pathway[14]
  •   Rela pathway[17]
  •   Rho pathway[33]
  •   Rna pathway[11]
  •   Salmonella pathway[14]
  •   Sars pathway[11]
  •   Set pathway[12]
  •   Shh pathway[17]
  •   Skp2e2f pathway[11]
  •   Sodd pathway[11]
  •   Sppa pathway[23]
  •   Spry pathway[19]
  •   Srcrptp pathway[12]
  •   Stathmin pathway[20]
  •   Stem pathway[16]
  •   Stress pathway[26]
  •   Tall1 pathway[16]
  •   Tcapoptosis pathway[12]
  •   Tcr pathway[50]
  •   Tcra pathway[14]
  •   Tcytotoxic pathway[15]
  •   Tel pathway[19]
  •   Tff pathway[22]
  •   Tgfb pathway[20]
  •   Th1th2 pathway[20]
  •   Thelper pathway[15]
  •   Tid pathway[20]
  •   Tnfr1 pathway[30]
  •   Tnfr2 pathway[19]
  •   Tob1 pathway[22]
  •   Toll pathway[38]
  •   Tpo pathway[25]
  •   Trka pathway[13]
  •   Ucalpain pathway[19]
  •   Vdr pathway[13]
  •   Vegf pathway[30]
  •   Vip pathway[30]
  •   Vitcb pathway[12]
  •   Wnt pathway[27]
  •   Abc transporters[45]
  •   Acute myeloid leukemia[61]
  •   Adherens junction[76]
  •   Adipocytokine signaling pathway[68]
  •   Alanine aspartate and glutamate metabolism[33]
  •   Aldosterone regulated sodium reabsorption[43]
  •   Allograft rejection[39]
  •   Alpha linolenic acid metabolism[20]
  •   Alzheimers disease[170]
  •   Amino sugar and nucleotide sugar metabolism[45]
  •   Aminoacyl trna biosynthesis[42]
  •   Amyotrophic lateral sclerosis als[54]
  •   Antigen processing and presentation[90]
  •   Apoptosis[89]
  •   Arachidonic acid metabolism[59]
  •   Arginine and proline metabolism[55]
  •   Arrhythmogenic right ventricular cardiomyopathy arvc[77]
  •   Ascorbate and aldarate metabolism[26]
  •   Asthma[31]
  •   Autoimmune thyroid disease[54]
  •   Axon guidance[130]
  •   B cell receptor signaling pathway[76]
  •   Basal cell carcinoma[56]
  •   Basal transcription factors[37]
  •   Base excision repair[36]
  •   Beta alanine metabolism[23]
  •   Biosynthesis of unsaturated fatty acids[23]
  •   Bladder cancer[43]
  •   Butanoate metabolism[35]
  •   Calcium signaling pathway[179]
  •   Cardiac muscle contraction[81]
  •   Cell adhesion molecules cams[135]
  •   Cell cycle[129]
  •   Chemokine signaling pathway[191]
  •   Chronic myeloid leukemia[74]
  •   Circadian rhythm mammal[14]
  •   Citrate cycle tca cycle[33]
  •   Colorectal cancer[63]
  •   Complement and coagulation cascades[70]
  •   Cysteine and methionine metabolism[35]
  •   Cytokine cytokine receptor interaction[268]
  •   Cytosolic dna sensing pathway[57]
  •   Dilated cardiomyopathy[93]
  •   Dna replication[37]
  •   Dorso ventral axis formation[26]
  •   Drug metabolism cytochrome p450[73]
  •   Drug metabolism other enzymes[52]
  •   Ecm receptor interaction[85]
  •   Endocytosis[184]
  •   Endometrial cancer[53]
  •   Epithelial cell signaling in helicobacter pylori infection[69]
  •   Erbb signaling pathway[88]
  •   Ether lipid metabolism[34]
  •   Fatty acid metabolism[43]
  •   Fc epsilon ri signaling pathway[80]
  •   Fc gamma r mediated phagocytosis[98]
  •   Focal adhesion[202]
  •   Folate biosynthesis[12]
  •   Fructose and mannose metabolism[35]
  •   Galactose metabolism[27]
  •   Gap junction[91]
  •   Glioma[66]
  •   Glutathione metabolism[51]
  •   Glycerolipid metabolism[50]
  •   Glycerophospholipid metabolism[78]
  •   Glycine serine and threonine metabolism[32]
  •   Glycolysis gluconeogenesis[63]
  •   Glycosaminoglycan biosynthesis chondroitin sulfate[23]
  •   Glycosaminoglycan biosynthesis heparan sulfate[27]
  •   Glycosaminoglycan biosynthesis keratan sulfate[16]
  •   Glycosaminoglycan degradation[22]
  •   Glycosphingolipid biosynthesis ganglio series[16]
  •   Glycosphingolipid biosynthesis globo series[15]
  •   Glycosphingolipid biosynthesis lacto and neolacto series[27]
  •   Glycosylphosphatidylinositol gpi anchor biosynthesis[26]
  •   Glyoxylate and dicarboxylate metabolism[17]
  •   Gnrh signaling pathway[102]
  •   Graft versus host disease[43]
  •   Hedgehog signaling pathway[57]
  •   Hematopoietic cell lineage[89]
  •   Histidine metabolism[30]
  •   Homologous recombination[29]
  •   Huntingtons disease[186]
  •   Hypertrophic cardiomyopathy hcm[86]
  •   Inositol phosphate metabolism[55]
  •   Insulin signaling pathway[138]
  •   Intestinal immune network for iga production[49]
  •   Jak stat signaling pathway[156]
  •   Leishmania infection[73]
  •   Leukocyte transendothelial migration[119]
  •   Limonene and pinene degradation[11]
  •   Linoleic acid metabolism[30]
  •   Long term depression[71]
  •   Long term potentiation[71]
  •   Lysine degradation[45]
  •   Lysosome[122]
  •   Mapk signaling pathway[268]
  •   Maturity onset diabetes of the young[26]
  •   Melanogenesis[103]
  •   Melanoma[72]
  •   Metabolism of xenobiotics by cytochrome p450[71]
  •   Mismatch repair[24]
  •   Mtor signaling pathway[53]
  •   N glycan biosynthesis[47]
  •   Natural killer cell mediated cytotoxicity[138]
  •   Neuroactive ligand receptor interaction[273]
  •   Neurotrophin signaling pathway[127]
  •   Nicotinate and nicotinamide metabolism[25]
  •   Nitrogen metabolism[24]
  •   Nod like receptor signaling pathway[63]
  •   Non homologous end joining[15]
  •   Non small cell lung cancer[55]
  •   Notch signaling pathway[48]
  •   Nucleotide excision repair[45]
  •   O glycan biosynthesis[31]
  •   Olfactory transduction[390]
  •   One carbon pool by folate[18]
  •   Oocyte meiosis[115]
  •   Other glycan degradation[17]
  •   Oxidative phosphorylation[136]
  •   P53 signaling pathway[70]
  •   Pancreatic cancer[71]
  •   Pantothenate and coa biosynthesis[17]
  •   Parkinsons disease[134]
  •   Pathogenic escherichia coli infection[60]
  •   Pathways in cancer[329]
  •   Pentose and glucuronate interconversions[29]
  •   Pentose phosphate pathway[28]
  •   Peroxisome[79]
  •   Phenylalanine metabolism[19]
  •   Phosphatidylinositol signaling system[77]
  •   Porphyrin and chlorophyll metabolism[42]
  •   Ppar signaling pathway[70]
  •   Primary bile acid biosynthesis[17]
  •   Primary immunodeficiency[36]
  •   Prion diseases[36]
  •   Progesterone mediated oocyte maturation[87]
  •   Propanoate metabolism[34]
  •   Prostate cancer[90]
  •   Proteasome[49]
  •   Protein export[25]
  •   Proximal tubule bicarbonate reclamation[24]
  •   Purine metabolism[160]
  •   Pyrimidine metabolism[99]
  •   Pyruvate metabolism[41]
  •   Regulation of actin cytoskeleton[217]
  •   Regulation of autophagy[36]
  •   Renal cell carcinoma[71]
  •   Renin angiotensin system[18]
  •   Retinol metabolism[65]
  •   Riboflavin metabolism[17]
  •   Ribosome[89]
  •   Rig i like receptor signaling pathway[72]
  •   Rna degradation[60]
  •   Rna polymerase[30]
  •   Selenoamino acid metabolism[27]
  •   Small cell lung cancer[85]
  •   Snare interactions in vesicular transport[39]
  •   Sphingolipid metabolism[41]
  •   Spliceosome[129]
  •   Starch and sucrose metabolism[53]
  •   Steroid biosynthesis[18]
  •   Steroid hormone biosynthesis[56]
  •   Sulfur metabolism[14]
  •   Systemic lupus erythematosus[141]
  •   T cell receptor signaling pathway[109]
  •   Taste transduction[53]
  •   Taurine and hypotaurine metabolism[11]
  •   Terpenoid backbone biosynthesis[16]
  •   Tgf beta signaling pathway[87]
  •   Thyroid cancer[30]
  •   Tight junction[135]
  •   Toll like receptor signaling pathway[103]
  •   Tryptophan metabolism[41]
  •   Type i diabetes mellitus[45]
  •   Type ii diabetes mellitus[48]
  •   Tyrosine metabolism[43]
  •   Ubiquitin mediated proteolysis[139]
  •   Valine leucine and isoleucine biosynthesis[12]
  •   Valine leucine and isoleucine degradation[45]
  •   Vascular smooth muscle contraction[116]
  •   Vasopressin regulated water reabsorption[45]
  •   Vegf signaling pathway[77]
  •   Vibrio cholerae infection[57]
  •   Viral myocarditis[74]
  •   Wnt signaling pathway[152]
  •   3 utr mediated translational regulation[177]
  •   A tetrasaccharide linker sequence is required for gag synthesis[26]
  •   Abacavir transport and metabolism[11]
  •   Abc family proteins mediated transport[35]
  •   Abca transporters in lipid homeostasis[19]
  •   Abortive elongation of hiv1 transcript in the absence of tat[24]
  •   Acetylcholine binding and downstream events[17]
  •   Acetylcholine neurotransmitter release cycle[11]
  •   Activated ampk stimulates fatty acid oxidation in muscle[20]
  •   Activated notch1 transmits signal to the nucleus[28]
  •   Activated point mutants of fgfr2[17]
  •   Activated tak1 mediates p38 mapk activation[19]
  •   Activated tlr4 signalling[94]
  •   Activation of atr in response to replication stress[39]
  •   Activation of bh3 only proteins[18]
  •   Activation of chaperone genes by atf6 alpha[12]
  •   Activation of chaperone genes by xbp1s[47]
  •   Activation of chaperones by atf6 alpha[14]
  •   Activation of genes by atf4[27]
  •   Activation of irf3 irf7 mediated by tbk1 ikk epsilon[15]
  •   Activation of kainate receptors upon glutamate binding[32]
  •   Activation of nf kappab in b cells[65]
  •   Activation of nmda receptor upon glutamate binding and postsynaptic events[38]
  •   Activation of rac[15]
  •   Activation of the ap1 family of transcription factors[11]
  •   Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s[85]
  •   Activation of the pre replicative complex[32]
  •   Acyl chain remodelling of pc[23]
  •   Acyl chain remodelling of pe[22]
  •   Acyl chain remodelling of pg[17]
  •   Acyl chain remodelling of pi[16]
  •   Acyl chain remodelling of ps[16]
  •   Adaptive immune system[540]
  •   Adenylate cyclase activating pathway[11]
  •   Adenylate cyclase inhibitory pathway[14]
  •   Adherens junctions interactions[28]
  •   Adp signalling through p2ry1[26]
  •   Adp signalling through p2ry12[22]
  •   Advanced glycosylation endproduct receptor signaling[14]
  •   Akt phosphorylates targets in the cytosol[13]
  •   Alpha linolenic acid ala metabolism[13]
  •   Amine compound slc transporters[28]
  •   Amine derived hormones[16]
  •   Amine ligand binding receptors[39]
  •   Amino acid and oligopeptide slc transporters[50]
  •   Amino acid synthesis and interconversion transamination[18]
  •   Amino acid transport across the plasma membrane[32]
  •   Amyloids[84]
  •   Androgen biosynthesis[11]
  •   Antigen activates b cell receptor leading to generation of second messengers[30]
  •   Antigen presentation folding assembly and peptide loading of class i mhc[22]
  •   Antigen processing cross presentation[77]
  •   Antigen processing ubiquitination proteasome degradation[213]
  •   Antiviral mechanism by ifn stimulated genes[67]
  •   Apc c cdc20 mediated degradation of cyclin b[27]
  •   Apc c cdc20 mediated degradation of mitotic proteins[74]
  •   Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1[73]
  •   Apc cdc20 mediated degradation of nek2a[29]
  •   Apobec3g mediated resistance to hiv1 infection[13]
  •   Apoptosis[149]
  •   Apoptosis induced dna fragmentation[14]
  •   Apoptotic cleavage of cell adhesion proteins[13]
  •   Apoptotic cleavage of cellular proteins[41]
  •   Apoptotic execution phase[55]
  •   Aquaporin mediated transport[52]
  •   Arms mediated activation[18]
  •   Asparagine n linked glycosylation[82]
  •   Assembly of the pre replicative complex[66]
  •   Association of licensing factors with the pre replicative complex[15]
  •   Association of tric cct with target proteins during biosynthesis[28]
  •   Autodegradation of cdh1 by cdh1 apc c[65]
  •   Autodegradation of the e3 ubiquitin ligase cop1[52]
  •   Axon guidance[252]
  •   Base excision repair[20]
  •   Base free sugar phosphate removal via the single nucleotide replacement pathway[11]
  •   Basigin interactions[31]
  •   Beta defensins[43]
  •   Bile acid and bile salt metabolism[28]
  •   Bile salt and organic anion slc transporters[12]
  •   Binding and entry of hiv virion[11]
  •   Biological oxidations[140]
  •   Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein[30]
  •   Bmal1 clock npas2 activates circadian expression[37]
  •   Botulinum neurotoxicity[20]
  •   Branched chain amino acid catabolism[18]
  •   Ca dependent events[31]
  •   Calnexin calreticulin cycle[12]
  •   Caspase mediated cleavage of cytoskeletal proteins[14]
  •   Cd28 co stimulation[33]
  •   Cd28 dependent pi3k akt signaling[23]
  •   Cd28 dependent vav1 pathway[12]
  •   Cdc6 association with the orc origin complex[12]
  •   Cdk mediated phosphorylation and removal of cdc6[49]
  •   Cdt1 association with the cdc6 orc origin complex[57]
  •   Cell cell communication[121]
  •   Cell cell junction organization[57]
  •   Cell cycle[422]
  •   Cell cycle checkpoints[125]
  •   Cell cycle mitotic[326]
  •   Cell death signalling via nrage nrif and nade[61]
  •   Cell extracellular matrix interactions[15]
  •   Cell junction organization[79]
  •   Cell surface interactions at the vascular wall[92]
  •   Cgmp effects[20]
  •   Chemokine receptors bind chemokines[58]
  •   Cholesterol biosynthesis[25]
  •   Chondroitin sulfate biosynthesis[22]
  •   Chondroitin sulfate dermatan sulfate metabolism[50]
  •   Chromosome maintenance[123]
  •   Chylomicron mediated lipid transport[17]
  •   Circadian clock[54]
  •   Circadian repression of expression by rev erba[24]
  •   Citric acid cycle tca cycle[27]
  •   Class a1 rhodopsin like receptors[306]
  •   Class b 2 secretin family receptors[89]
  •   Class c 3 metabotropic glutamate pheromone receptors[16]
  •   Class i mhc mediated antigen processing presentation[252]
  •   Cleavage of growing transcript in the termination region [45]
  •   Collagen formation[59]
  •   Common pathway[15]
  •   Complement cascade[33]
  •   Conversion from apc c cdc20 to apc c cdh1 in late anaphase[23]
  •   Copi mediated transport[11]
  •   Costimulation by the cd28 family[64]
  •   Creation of c4 and c2 activators[11]
  •   Creb phosphorylation through the activation of camkii[16]
  •   Creb phosphorylation through the activation of ras[28]
  •   Crmps in sema3a signaling[15]
  •   Cross presentation of soluble exogenous antigens endosomes[49]
  •   Cs ds degradation[13]
  •   Ctla4 inhibitory signaling[22]
  •   Ctnnb1 phosphorylation cascade[17]
  •   Cyclin a b1 associated events during g2 m transition[16]
  •   Cyclin e associated events during g1 s transition [66]
  •   Cytochrome p450 arranged by substrate type[52]
  •   Cytokine signaling in immune system[271]
  •   Cytosolic sulfonation of small molecules[15]
  •   Cytosolic trna aminoacylation[25]
  •   Dag and ip3 signaling[33]
  •   Darpp 32 events[26]
  •   Dcc mediated attractive signaling[14]
  •   Deadenylation dependent mrna decay[49]
  •   Deadenylation of mrna[23]
  •   Defensins[52]
  •   Degradation of the extracellular matrix[30]
  •   Deposition of new cenpa containing nucleosomes at the centromere[65]
  •   Destabilization of mrna by auf1 hnrnp d0[54]
  •   Destabilization of mrna by brf1[18]
  •   Destabilization of mrna by ksrp[18]
  •   Destabilization of mrna by tristetraprolin ttp[18]
  •   Developmental biology[397]
  •   Diabetes pathways[134]
  •   Digestion of dietary carbohydrate[13]
  •   Dna repair[113]
  •   Dna replication[193]
  •   Dna strand elongation[31]
  •   Dopamine neurotransmitter release cycle[12]
  •   Double strand break repair[25]
  •   Downregulation of erbb2 erbb3 signaling[13]
  •   Downregulation of smad2 3 smad4 transcriptional activity[21]
  •   Downregulation of tgf beta receptor signaling[24]
  •   Downstream signal transduction[96]
  •   Downstream signaling events of b cell receptor bcr[98]
  •   Downstream signaling of activated fgfr[101]
  •   Downstream tcr signaling[38]
  •   Dscam interactions[12]
  •   E2f enabled inhibition of pre replication complex formation[11]
  •   E2f mediated regulation of dna replication[36]
  •   Early phase of hiv life cycle[22]
  •   Effects of pip2 hydrolysis[26]
  •   Egfr downregulation[26]
  •   Eicosanoid ligand binding receptors[17]
  •   Elevation of cytosolic ca2 levels[11]
  •   Elongation arrest and recovery[33]
  •   Endogenous sterols[16]
  •   Endosomal sorting complex required for transport escrt[28]
  •   Endosomal vacuolar pathway[10]
  •   Energy dependent regulation of mtor by lkb1 ampk[19]
  •   Enos activation and regulation[21]
  •   Er phagosome pathway[62]
  •   Erk mapk targets[22]
  •   Erks are inactivated[13]
  •   Ethanol oxidation[11]
  •   Extension of telomeres[28]
  •   Extracellular matrix organization[88]
  •   Extrinsic pathway for apoptosis[14]
  •   Facilitative na independent glucose transporters[13]
  •   Factors involved in megakaryocyte development and platelet production[133]
  •   Fanconi anemia pathway[26]
  •   Fatty acid triacylglycerol and ketone body metabolism[169]
  •   Fatty acyl coa biosynthesis[19]
  •   Fgfr ligand binding and activation[23]
  •   Fgfr1 ligand binding and activation[15]
  •   Fgfr2c ligand binding and activation[13]
  •   Fgfr4 ligand binding and activation[13]
  •   Formation of atp by chemiosmotic coupling[17]
  •   Formation of fibrin clot clotting cascade[33]
  •   Formation of incision complex in gg ner[24]
  •   Formation of rna pol ii elongation complex [46]
  •   Formation of the hiv1 early elongation complex[35]
  •   Formation of the ternary complex and subsequently the 43s complex[75]
  •   Formation of transcription coupled ner tc ner repair complex[31]
  •   Formation of tubulin folding intermediates by cct tric[23]
  •   Frs2 mediated cascade[37]
  •   G alpha i signalling events[196]
  •   G alpha q signalling events[185]
  •   G alpha s signalling events[122]
  •   G alpha z signalling events[45]
  •   G alpha1213 signalling events[75]
  •   G beta gamma signalling through pi3kgamma[26]
  •   G beta gamma signalling through plc beta[21]
  •   G protein activation[28]
  •   G protein beta gamma signalling[29]
  •   G0 and early g1[26]
  •   G1 phase[39]
  •   G1 s specific transcription[20]
  •   G1 s transition[113]
  •   G2 m checkpoints[46]
  •   G2 m dna damage checkpoint[13]
  •   Gab1 signalosome[39]
  •   Gaba a receptor activation[13]
  •   Gaba b receptor activation[39]
  •   Gaba receptor activation[53]
  •   Gaba synthesis release reuptake and degradation[18]
  •   Gamma carboxylation transport and amino terminal cleavage of proteins[12]
  •   Gap junction assembly[19]
  •   Gap junction degradation[11]
  •   Gap junction trafficking[28]
  •   Gastrin creb signalling pathway via pkc and mapk[206]
  •   Generation of second messenger molecules[28]
  •   Generic transcription pathway[353]
  •   Global genomic ner gg ner[36]
  •   Glucagon signaling in metabolic regulation[35]
  •   Glucagon type ligand receptors[34]
  •   Gluconeogenesis[35]
  •   Glucose metabolism[70]
  •   Glucose transport[39]
  •   Glucuronidation[19]
  •   Glutamate neurotransmitter release cycle[16]
  •   Glutathione conjugation[24]
  •   Glycerophospholipid biosynthesis[83]
  •   Glycogen breakdown glycogenolysis[19]
  •   Glycolysis[30]
  •   Glycoprotein hormones[13]
  •   Glycosaminoglycan metabolism[112]
  •   Glycosphingolipid metabolism[39]
  •   Golgi associated vesicle biogenesis[54]
  •   Gpcr downstream signaling[806]
  •   Gpcr ligand binding[409]
  •   Gpvi mediated activation cascade[32]
  •   Grb2 events in erbb2 signaling[23]
  •   Grb2 sos provides linkage to mapk signaling for intergrins [16]
  •   Growth hormone receptor signaling[25]
  •   Hdl mediated lipid transport[16]
  •   Hemostasis[467]
  •   Heparan sulfate heparin hs gag metabolism[53]
  •   Highly calcium permeable postsynaptic nicotinic acetylcholine receptors[14]
  •   Hiv infection[208]
  •   Hiv life cycle[126]
  •   Homologous recombination repair of replication independent double strand breaks[18]
  •   Hormone ligand binding receptors[11]
  •   Hormone sensitive lipase hsl mediated triacylglycerol hydrolysis[14]
  •   Host interactions of hiv factors[133]
  •   Hs gag biosynthesis[32]
  •   Hs gag degradation[21]
  •   Hyaluronan metabolism[15]
  •   Hyaluronan uptake and degradation[11]
  •   Ikk complex recruitment mediated by rip1[11]
  •   Il 2 signaling[42]
  •   Il 3 5 and gm csf signaling[44]
  •   Il 6 signaling[12]
  •   Il 7 signaling[12]
  •   Il receptor shc signaling[28]
  •   Il1 signaling[40]
  •   Immune system[934]
  •   Immunoregulatory interactions between a lymphoid and a non lymphoid cell[71]
  •   Incretin synthesis secretion and inactivation[23]
  •   Inflammasomes[18]
  •   Influenza life cycle[204]
  •   Influenza viral rna transcription and replication[170]
  •   Inhibition of insulin secretion by adrenaline noradrenaline[26]
  •   Inhibition of replication initiation of damaged dna by rb1 e2f1[14]
  •   Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components[25]
  •   Inhibition of voltage gated ca2 channels via gbeta gamma subunits[26]
  •   Initial triggering of complement[17]
  •   Innate immune system[280]
  •   Insulin receptor recycling[24]
  •   Insulin receptor signalling cascade[88]
  •   Insulin synthesis and processing[22]
  •   Integration of energy metabolism[121]
  •   Integration of provirus[17]
  •   Integrin alphaiib beta3 signaling[28]
  •   Integrin cell surface interactions[80]
  •   Interaction between l1 and ankyrins[24]
  •   Interactions of vpr with host cellular proteins[34]
  •   Interferon alpha beta signaling[65]
  •   Interferon gamma signaling[64]
  •   Interferon signaling[160]
  •   Intrinsic pathway[18]
  •   Intrinsic pathway for apoptosis[31]
  •   Inwardly rectifying k channels[32]
  •   Ion channel transport[56]
  •   Ion transport by p type atpases[35]
  •   Ionotropic activity of kainate receptors[12]
  •   Irak1 recruits ikk complex[11]
  •   Irak2 mediated activation of tak1 complex upon tlr7 8 or 9 stimulation[10]
  •   Iron uptake and transport[37]
  •   Jnk c jun kinases phosphorylation and activation mediated by activated human tak1[17]
  •   Keratan sulfate biosynthesis[27]
  •   Keratan sulfate degradation[12]
  •   Keratan sulfate keratin metabolism[31]
  •   Kinesins[25]
  •   L1cam interactions[87]
  •   Lagging strand synthesis[20]
  •   Late phase of hiv life cycle[105]
  •   Latent infection of homo sapiens with mycobacterium tuberculosis[34]
  •   Ligand gated ion channel transport[22]
  •   Lipid digestion mobilization and transport[47]
  •   Lipoprotein metabolism[29]
  •   Loss of nlp from mitotic centrosomes[60]
  •   Lysosome vesicle biogenesis[24]
  •   M g1 transition[82]
  •   Map kinase activation in tlr cascade[51]
  •   Mapk targets nuclear events mediated by map kinases[31]
  •   Meiosis[117]
  •   Meiotic recombination[87]
  •   Meiotic synapsis[74]
  •   Membrane binding and targetting of gag proteins[11]
  •   Membrane trafficking[130]
  •   Metabolism of amino acids and derivatives[201]
  •   Metabolism of carbohydrates[248]
  •   Metabolism of lipids and lipoproteins[479]
  •   Metabolism of mrna[285]
  •   Metabolism of non coding rna[50]
  •   Metabolism of nucleotides[73]
  •   Metabolism of polyamines[16]
  •   Metabolism of porphyrins[15]
  •   Metabolism of proteins[519]
  •   Metabolism of rna[331]
  •   Metabolism of steroid hormones and vitamins a and d[36]
  •   Metabolism of vitamins and cofactors[52]
  •   Metal ion slc transporters[23]
  •   Mhc class ii antigen presentation[92]
  •   Microrna mirna biogenesis[24]
  •   Mitochondrial fatty acid beta oxidation[15]
  •   Mitochondrial protein import[59]
  •   Mitochondrial trna aminoacylation[22]
  •   Mitotic g1 g1 s phases[138]
  •   Mitotic g2 g2 m phases[82]
  •   Mitotic m m g1 phases[173]
  •   Mitotic prometaphase[88]
  •   Mrna 3 end processing[36]
  •   Mrna capping[31]
  •   Mrna decay by 3 to 5 exoribonuclease[12]
  •   Mrna decay by 5 to 3 exoribonuclease[16]
  •   Mrna processing[162]
  •   Mrna splicing[112]
  •   Mrna splicing minor pathway[46]
  •   Mtorc1 mediated signalling[12]
  •   Muscle contraction[49]
  •   Myd88 mal cascade initiated on plasma membrane[84]
  •   Myogenesis[29]
  •   N glycan antennae elongation[15]
  •   N glycan antennae elongation in the medial trans golgi[19]
  •   N glycan trimming in the er and calnexin calreticulin cycle[14]
  •   Na cl dependent neurotransmitter transporters[18]
  •   Ncam signaling for neurite out growth[65]
  •   Ncam1 interactions[40]
  •   Nef mediated downregulation of mhc class i complex cell surface expression[11]
  •   Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters[22]
  •   Negative regulation of fgfr signaling[38]
  •   Negative regulation of the pi3k akt network[10]
  •   Negative regulators of rig i mda5 signaling[32]
  •   Nep ns2 interacts with the cellular export machinery[28]
  •   Nephrin interactions[21]
  •   Netrin1 signaling[42]
  •   Neuronal system[280]
  •   Neurotransmitter receptor binding and downstream transmission in the postsynaptic cell[138]
  •   Neurotransmitter release cycle[35]
  •   Nfkb activation through fadd rip1 pathway mediated by caspase 8 and10[13]
  •   Nfkb and map kinases activation mediated by tlr4 signaling repertoire[73]
  •   Nfkb is activated and signals survival[12]
  •   Ngf signalling via trka from the plasma membrane[138]
  •   Nitric oxide stimulates guanylate cyclase[26]
  •   Nod1 2 signaling pathway[31]
  •   Nonsense mediated decay enhanced by the exon junction complex[177]
  •   Norepinephrine neurotransmitter release cycle[11]
  •   Notch hlh transcription pathway[14]
  •   Notch1 intracellular domain regulates transcription[47]
  •   Nrage signals death through jnk[44]
  •   Nrif signals cell death from the nucleus[16]
  •   Nuclear events kinase and transcription factor activation[25]
  •   Nuclear receptor transcription pathway[50]
  •   Nuclear signaling by erbb4[39]
  •   Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways[47]
  •   Nucleotide excision repair[52]
  •   Nucleotide like purinergic receptors[17]
  •   O linked glycosylation of mucins[60]
  •   Olfactory signaling pathway[329]
  •   Opioid signalling[79]
  •   Opsins[11]
  •   Orc1 removal from chromatin[68]
  •   Organic cation anion zwitterion transport[14]
  •   Other semaphorin interactions[16]
  •   Oxygen dependent proline hydroxylation of hypoxia inducible factor alpha[19]
  •   P130cas linkage to mapk signaling for integrins[16]
  •   P2y receptors[13]
  •   P38mapk events[14]
  •   P53 dependent g1 dna damage response[58]
  •   P53 independent g1 s dna damage checkpoint[52]
  •   P75 ntr receptor mediated signalling[82]
  •   P75ntr recruits signalling complexes[13]
  •   P75ntr signals via nfkb[15]
  •   Packaging of telomere ends[49]
  •   Passive transport by aquaporins[12]
  •   Pd1 signaling[19]
  •   Pecam1 interactions[11]
  •   Peptide chain elongation[154]
  •   Peptide hormone biosynthesis[15]
  •   Peptide ligand binding receptors[189]
  •   Perk regulated gene expression[30]
  •   Peroxisomal lipid metabolism[22]
  •   Phase ii conjugation[71]
  •   Phase1 functionalization of compounds[71]
  •   Phospholipase c mediated cascade[55]
  •   Phospholipid metabolism[199]
  •   Phosphorylation of cd3 and tcr zeta chains[17]
  •   Phosphorylation of the apc c[24]
  •   Pi 3k cascade[57]
  •   Pi metabolism[49]
  •   Pi3k akt activation[39]
  •   Pi3k cascade[72]
  •   Pi3k events in erbb2 signaling[45]
  •   Pi3k events in erbb4 signaling[39]
  •   Pip3 activates akt signaling[30]
  •   Pka mediated phosphorylation of creb[19]
  •   Pkb mediated events[30]
  •   Platelet activation signaling and aggregation[209]
  •   Platelet adhesion to exposed collagen[13]
  •   Platelet aggregation plug formation[37]
  •   Platelet calcium homeostasis[19]
  •   Platelet homeostasis[79]
  •   Platelet sensitization by ldl[17]
  •   Plc beta mediated events[44]
  •   Pol switching[14]
  •   Post chaperonin tubulin folding pathway[20]
  •   Post nmda receptor activation events[34]
  •   Post translational modification synthesis of gpi anchored proteins[27]
  •   Post translational protein modification[189]
  •   Potassium channels[99]
  •   Ppara activates gene expression[105]
  •   Pre notch expression and processing[45]
  •   Pre notch processing in golgi[17]
  •   Pre notch transcription and translation[30]
  •   Prefoldin mediated transfer of substrate to cct tric[29]
  •   Presynaptic nicotinic acetylcholine receptors[13]
  •   Processing of capped intron containing pre mrna[141]
  •   Processing of capped intronless pre mrna[24]
  •   Processing of intronless pre mrnas[15]
  •   Processive synthesis on the lagging strand[16]
  •   Prolactin receptor signaling[15]
  •   Prolonged erk activation events[20]
  •   Prostacyclin signalling through prostacyclin receptor[20]
  •   Prostanoid ligand receptors[11]
  •   Protein folding[54]
  •   Proteolytic cleavage of snare complex proteins[18]
  •   Ptm gamma carboxylation hypusine formation and arylsulfatase activation[28]
  •   Purine catabolism[11]
  •   Purine metabolism[34]
  •   Purine ribonucleoside monophosphate biosynthesis[12]
  •   Purine salvage[14]
  •   Pyrimidine catabolism[13]
  •   Pyrimidine metabolism[25]
  •   Pyruvate metabolism[20]
  •   Pyruvate metabolism and citric acid tca cycle[49]
  •   Raf map kinase cascade[11]
  •   Rap1 signalling[18]
  •   Ras activation uopn ca2 infux through nmda receptor[18]
  •   Receptor ligand binding initiates the second proteolytic cleavage of notch receptor[13]
  •   Recruitment of mitotic centrosome proteins and complexes[67]
  •   Recruitment of numa to mitotic centrosomes[11]
  •   Recycling of bile acids and salts[12]
  •   Recycling pathway of l1[28]
  •   Regulated proteolysis of p75ntr[11]
  •   Regulation of ampk activity via lkb1[16]
  •   Regulation of apoptosis[59]
  •   Regulation of beta cell development[31]
  •   Regulation of complement cascade[15]
  •   Regulation of gene expression in beta cells[21]
  •   Regulation of glucokinase by glucokinase regulatory protein[28]
  •   Regulation of hypoxia inducible factor hif by oxygen[26]
  •   Regulation of ifna signaling[25]
  •   Regulation of ifng signaling[15]
  •   Regulation of insulin like growth factor igf activity by insulin like growth factor binding proteins igfbps[17]
  •   Regulation of insulin secretion[94]
  •   Regulation of insulin secretion by acetylcholine[12]
  •   Regulation of insulin secretion by glucagon like peptide1[44]
  •   Regulation of kit signaling[18]
  •   Regulation of mitotic cell cycle[86]
  •   Regulation of mrna stability by proteins that bind au rich elements[85]
  •   Regulation of ornithine decarboxylase odc[50]
  •   Regulation of pyruvate dehydrogenase pdh complex[14]
  •   Regulation of rheb gtpase activity by ampk[11]
  •   Regulation of signaling by cbl[19]
  •   Regulation of the fanconi anemia pathway[12]
  •   Regulation of water balance by renal aquaporins[45]
  •   Regulatory rna pathways[27]
  •   Removal of the flap intermediate from the c strand[11]
  •   Repair synthesis for gap filling by dna pol in tc ner[15]
  •   Resolution of ap sites via the multiple nucleotide patch replacement pathway[18]
  •   Resolution of ap sites via the single nucleotide replacement pathway[13]
  •   Respiratory electron transport[80]
  •   Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins [99]
  •   Response to elevated platelet cytosolic ca2 [90]
  •   Retrograde neurotrophin signalling[14]
  •   Reversible hydration of carbon dioxide[13]
  •   Rig i mda5 mediated induction of ifn alpha beta pathways[74]
  •   Rip mediated nfkb activation via dai[19]
  •   Rna pol i promoter opening[63]
  •   Rna pol i rna pol iii and mitochondrial transcription[123]
  •   Rna pol i transcription[90]
  •   Rna pol i transcription initiation[26]
  •   Rna pol i transcription termination[23]
  •   Rna pol ii pre transcription events[62]
  •   Rna pol ii transcription[106]
  •   Rna pol ii transcription pre initiation and promoter opening[42]
  •   Rna pol iii chain elongation[18]
  •   Rna pol iii transcription[34]
  •   Rna pol iii transcription initiation from type 2 promoter[24]
  •   Rna pol iii transcription initiation from type 3 promoter[27]
  •   Rna pol iii transcription termination[20]
  •   Role of dcc in regulating apoptosis[11]
  •   Role of second messengers in netrin1 signaling[12]
  •   Rora activates circadian expression[25]
  •   S phase[110]
  •   Scf beta trcp mediated degradation of emi1[52]
  •   Scfskp2 mediated degradation of p27 p21[57]
  •   Sema3a pak dependent axon repulsion[16]
  •   Sema3a plexin repulsion signaling by inhibiting integrin adhesion[14]
  •   Sema4d in semaphorin signaling[33]
  •   Sema4d induced cell migration and growth cone collapse[28]
  •   Semaphorin interactions[69]
  •   Serotonin receptors[13]
  •   Shc mediated cascade[29]
  •   Shc mediated signalling[16]
  •   Shc related events[18]
  •   Shc1 events in egfr signaling[16]
  •   Shc1 events in erbb4 signaling[21]
  •   Signal amplification[32]
  •   Signal attenuation[15]
  •   Signal regulatory protein sirp family interactions[13]
  •   Signal transduction by l1[35]
  •   Signaling by activated point mutants of fgfr1[12]
  •   Signaling by bmp[24]
  •   Signaling by constitutively active egfr[19]
  •   Signaling by egfr in cancer[110]
  •   Signaling by erbb2[102]
  •   Signaling by erbb4[91]
  •   Signaling by fgfr[113]
  •   Signaling by fgfr in disease[128]
  •   Signaling by fgfr mutants[45]
  •   Signaling by fgfr1 fusion mutants[20]
  •   Signaling by fgfr1 mutants[31]
  •   Signaling by fgfr3 mutants[12]
  •   Signaling by gpcr[921]
  •   Signaling by hippo[23]
  •   Signaling by ils[108]
  •   Signaling by insulin receptor[109]
  •   Signaling by nodal[19]
  •   Signaling by notch[104]
  •   Signaling by notch1[71]
  •   Signaling by notch2[13]
  •   Signaling by notch3[13]
  •   Signaling by notch4[13]
  •   Signaling by pdgf[123]
  •   Signaling by rho gtpases[114]
  •   Signaling by robo receptor[31]
  •   Signaling by scf kit[79]
  •   Signaling by tgf beta receptor complex[64]
  •   Signaling by the b cell receptor bcr[127]
  •   Signaling by wnt[66]
  •   Signalling by ngf[218]
  •   Signalling to erks[37]
  •   Signalling to p38 via rit and rin[16]
  •   Signalling to ras[28]
  •   Slbp dependent processing of replication dependent histone pre mrnas[12]
  •   Slc mediated transmembrane transport[242]
  •   Smad2 smad3 smad4 heterotrimer regulates transcription[28]
  •   Smooth muscle contraction[26]
  •   Sos mediated signalling[15]
  •   Sphingolipid de novo biosynthesis[32]
  •   Sphingolipid metabolism[70]
  •   Spry regulation of fgf signaling[15]
  •   Srp dependent cotranslational protein targeting to membrane[180]
  •   Steroid hormones[30]
  •   Striated muscle contraction[28]
  •   Sulfur amino acid metabolism[25]
  •   Synthesis and interconversion of nucleotide di and triphosphates[20]
  •   Synthesis of bile acids and bile salts[20]
  •   Synthesis of bile acids and bile salts via 24 hydroxycholesterol[11]
  •   Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol[16]
  •   Synthesis of dna[93]
  •   Synthesis of glycosylphosphatidylinositol gpi[18]
  •   Synthesis of pa[28]
  •   Synthesis of pc[19]
  •   Synthesis of pe[12]
  •   Synthesis of pips at the early endosome membrane[13]
  •   Synthesis of pips at the golgi membrane[18]
  •   Synthesis of pips at the late endosome membrane[11]
  •   Synthesis of pips at the plasma membrane[32]
  •   Synthesis of substrates in n glycan biosythesis[15]
  •   Synthesis of very long chain fatty acyl coas[15]
  •   Synthesis secretion and deacylation of ghrelin[17]
  •   Synthesis secretion and inactivation of gip[15]
  •   Synthesis secretion and inactivation of glp1[20]
  •   Tak1 activates nfkb by phosphorylation and activation of ikks complex[24]
  •   Tandem pore domain potassium channels[13]
  •   Tca cycle and respiratory electron transport[142]
  •   Tcr signaling[55]
  •   Telomere maintenance[76]
  •   Termination of o glycan biosynthesis[25]
  •   Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation[14]
  •   Tgf beta receptor signaling activates smads[27]
  •   Tgf beta receptor signaling in emt epithelial to mesenchymal transition[17]
  •   The activation of arylsulfatases[13]
  •   The nlrp3 inflammasome[13]
  •   The role of nef in hiv1 replication and disease pathogenesis[29]
  •   Thrombin signalling through proteinase activated receptors pars[33]
  •   Thromboxane signalling through tp receptor[24]
  •   Tie2 signaling[18]
  •   Tight junction interactions[30]
  •   Toll receptor cascades[119]
  •   Traf3 dependent irf activation pathway[15]
  •   Traf6 mediated induction of nfkb and map kinases upon tlr7 8 or 9 activation[78]
  •   Traf6 mediated induction of tak1 complex[15]
  •   Traf6 mediated irf7 activation[31]
  •   Traf6 mediated irf7 activation in tlr7 8 or 9 signaling[11]
  •   Traf6 mediated nfkb activation[22]
  •   Trafficking and processing of endosomal tlr[15]
  •   Trafficking of ampa receptors[29]
  •   Trafficking of glur2 containing ampa receptors[17]
  •   Trans golgi network vesicle budding[61]
  •   Transcription[211]
  •   Transcription coupled ner tc ner[46]
  •   Transcriptional activity of smad2 smad3 smad4 heterotrimer[39]
  •   Transcriptional regulation of white adipocyte differentiation[73]
  •   Transferrin endocytosis and recycling[26]
  •   Translation[223]
  •   Translocation of zap 70 to immunological synapse[15]
  •   Transmembrane transport of small molecules[414]
  •   Transmission across chemical synapses[187]
  •   Transport of glucose and other sugars bile salts and organic acids metal ions and amine compounds[90]
  •   Transport of inorganic cations anions and amino acids oligopeptides[95]
  •   Transport of mature mrna derived from an intronless transcript[34]
  •   Transport of mature transcript to cytoplasm[55]
  •   Transport of organic anions[12]
  •   Transport of ribonucleoproteins into the host nucleus[28]
  •   Transport of vitamins nucleosides and related molecules[32]
  •   Transport to the golgi and subsequent modification[34]
  •   Trif mediated tlr3 signaling[75]
  •   Triglyceride biosynthesis[39]
  •   Trna aminoacylation[43]
  •   Tryptophan catabolism[12]
  •   Unblocking of nmda receptor glutamate binding and activation[16]
  •   Unfolded protein response[81]
  •   Unwinding of dna[12]
  •   Vegf ligand receptor interactions[11]
  •   Vif mediated degradation of apobec3g[53]
  •   Viral messenger rna synthesis[15]
  •   Vitamin b5 pantothenate metabolism[12]
  •   Voltage gated potassium channels[44]
  •   Xenobiotics[17]
  •   Yap1 and wwtr1 taz stimulated gene expression[25]
  •   Zinc transporters[16]
Sample Grouping
1 GSM263590 1 hour biopsy sample of transplanted kidney from DCD 1 donor kidney sample from DCD donor (1 hr after reperfusion)
2 GSM263591 1 hour biopsy sample of transplanted kidney from DCD 2 donor kidney sample from DCD donor (1 hr after reperfusion)
3 GSM263592 1 hour biopsy sample of transplanted kidney from DCD 3 donor kidney sample from DCD donor (1 hr after reperfusion)
4 GSM263593 1 hour biopsy sample of transplanted kidney from DCD 4 donorkidney sample from DCD donor (1 hr after reperfusion)
5 GSM263594 1 hour biopsy sample of transplanted kidney from DCD 5 donor kidney sample from DCD donor (1 hr after reperfusion)
6 GSM263595 1 hour biopsy sample of transplanted kidney from DCD 6 donor kidney sample from DCD donor (1 hr after reperfusion)
7 GSM263596 1 hour biopsy sample of transplanted kidney from DCD 7 donor kidney sample from DCD donor (1 hr after reperfusion)
8 GSM263597 1 hour biopsy sample of transplanted kidney from DCD 8 donor kidney sample from DCD donor (1 hr after reperfusion)
9 GSM263598 1 hour biopsy sample of transplanted kidney from DCD 9 donor kidney sample from DCD donor (1 hr after reperfusion)
10 GSM263599 1 hour biopsy sample of transplanted kidney from DCD 10 donor kidney sample from DCD donor (1 hr after reperfusion)
11 GSM263600 1 hour biopsy sample of transplanted kidney from DCD 11 donor kidney sample from DCD donor (1 hr after reperfusion)
12 GSM263601 1 hour biopsy sample of transplanted kidney from DCD 12 donor kidney sample from DCD donor (1 hr after reperfusion)
13 GSM263602 1 hour biopsy sample of transplanted kidney from DCD 13 donor kidney sample from DCD donor (1 hr after reperfusion)
14 GSM263603 1 hour biopsy sample of transplanted kidney from DCD 14 donor kidney sample from DCD donor (1 hr after reperfusion)
1 GSM263619 1 hour biopsy sample of transplanted kidney from LD 1 donor kidney sample from LD donor (1 hr after reperfusion)
2 GSM263620 1 hour biopsy sample of transplanted kidney from LD 2 donor kidney sample from LD donor (1 hr after reperfusion)
3 GSM263621 1 hour biopsy sample of transplanted kidney from LD 3 donor kidney sample from LD donor (1 hr after reperfusion)
4 GSM263622 1 hour biopsy sample of transplanted kidney from LD 4 donor kidney sample from LD donor (1 hr after reperfusion)
5 GSM263623 1 hour biopsy sample of transplanted kidney from LD 5 donorkidney sample from LD donor (1 hr after reperfusion)
6 GSM263624 1 hour biopsy sample of transplanted kidney from LD 6 donor kidney sample from LD donor (1 hr after reperfusion)
7 GSM263625 1 hour biopsy sample of transplanted kidney from LD 7 donor kidney sample from LD donor (1 hr after reperfusion)
8 GSM263626 1 hour biopsy sample of transplanted kidney from LD 8 donor kidney sample from LD donor (1 hr after reperfusion)
9 GSM263627 1 hour biopsy sample of transplanted kidney from LD 9 donor kidney sample from LD donor (1 hr after reperfusion)
10 GSM263628 1 hour biopsy sample of transplanted kidney from LD 10 donor kidney sample from LD donor (1 hr after reperfusion)
11 GSM263629 1 hour biopsy sample of transplanted kidney from LD 11 donor kidney sample from LD donor (1 hr after reperfusion)
12 GSM263630 1 hour biopsy sample of transplanted kidney from LD 12 donor kidney sample from LD donor (1 hr after reperfusion)
13 GSM263631 1 hour biopsy sample of transplanted kidney from LD 13 donor kidney sample from LD donor (1 hr after reperfusion)
14 GSM263632 1 hour biopsy sample of transplanted kidney from LD 14 donor kidney sample from LD donor (1 hr after reperfusion)
15 GSM263633 1 hour biopsy sample of transplanted kidney from LD 15 donor kidney sample from LD donor (1 hr after reperfusion)
Gene Information
Official Symbol
NOTCH1
Officical Full Name
notch 1
Primary Source
HGNC:7881
See related
MIM:190198 Ensembl:ENSG00000148400 HPRD:01827 Vega:OTTHUMG00000020935
Chromosome Location
9q34.3
Gene Type
protein-coding
Also known as
TAN1 hN1
External Sources
GUDMAP
Experiment Description
Accession
RGED10419
Type
Microarray
Summary
Because of world-wide shortage of renal grafts, kidney transplantation (KTx) from donors after cardiac death (DCD) is an alternative way to KTx from brain-dead donors. Although the prognosis of DCD KTx is gradually improving, the graft often undergoes delayed graft function (DGF) rendering the control of DGF essential for post-KTx patient care. To know the etiology of the DGF, we performed genome-wide gene expression profiling using renal biopsy samples performed at 1 hour after KTx from DCD and compared the data with those of KTx from living donors (LD). A total of 526 genes were differentially expressed between them. Genes involved in acute inflammation were activated, while metabolic pathways were consistently down-regulated in DCD. All of these findings imply inferior performance of the DCD grafts relative to LD grafts. We identified several genes of which expression levels were correlated well with parameters indicating short- and long-term prognosis of the DCD patients. In addition, we identified several genes encoding secretory proteins that might reflect the performance of the graft and be potent non-invasive biomarkers. Our data provide good source for candidates of biomarker that are potentially useful for control of DGF.
Experiment Platform
Agilent-012097 Human 1A Microarray (V2) G4110B (Feature Number version)
Data Source
GSE10419