NOTCH1 Expression Profiles in Kidney Transplantation

Tool Box: Similarity Analysis

Select from the Gene Set

Biocarta Pathway
  •   41bb pathway[18]
  •   Ace2 pathway[14]
  •   Ach pathway[17]
  •   Actiny pathway[21]
  •   Agpcr pathway[14]
  •   Agr pathway[37]
  •   Ahsp pathway[14]
  •   Akap13 pathway[13]
  •   Akap95 pathway[13]
  •   Akapcentrosome pathway[16]
  •   Akt pathway[23]
  •   Alk pathway[38]
  •   Ami pathway[21]
  •   Arap pathway[19]
  •   Arenrf2 pathway[14]
  •   Arf pathway[18]
  •   Asbcell pathway[13]
  •   At1r pathway[37]
  •   Atm pathway[21]
  •   Atrbrca pathway[22]
  •   Bad pathway[27]
  •   Barr mapk pathway[13]
  •   Barrestin pathway[11]
  •   Barrestin src pathway[16]
  •   Bcellsurvival pathway[17]
  •   Bcr pathway[38]
  •   Biopeptides pathway[46]
  •   Blymphocyte pathway[12]
  •   Cacam pathway[17]
  •   Calcineurin pathway[22]
  •   Cardiacegf pathway[19]
  •   Carm er pathway[36]
  •   Carm1 pathway[14]
  •   Caspase pathway[24]
  •   Cbl pathway[14]
  •   Ccr3 pathway[24]
  •   Ccr5 pathway[21]
  •   Cd40 pathway[16]
  •   Cdc42rac pathway[17]
  •   Cdk5 pathway[12]
  •   Cdmac pathway[17]
  •   Cell2cell pathway[15]
  •   Cellcycle pathway[24]
  •   Ceramide pathway[23]
  •   Cftr pathway[13]
  •   Chemical pathway[23]
  •   Chrebp2 pathway[43]
  •   Ck1 pathway[18]
  •   Classic pathway[15]
  •   Comp pathway[20]
  •   Creb pathway[28]
  •   Csk pathway[25]
  •   Ctcf pathway[24]
  •   Ctl pathway[16]
  •   Ctla4 pathway[22]
  •   Cxcr4 pathway[25]
  •   Cytokine pathway[23]
  •   D4gdi pathway[14]
  •   Dc pathway[23]
  •   Death pathway[34]
  •   Dnafragment pathway[11]
  •   Dream pathway[15]
  •   Ecm pathway[25]
  •   Edg1 pathway[28]
  •   Egf pathway[32]
  •   Egfr smrte pathway[12]
  •   Eif pathway[17]
  •   Eif2 pathway[12]
  •   Eif4 pathway[25]
  •   Epha4 pathway[11]
  •   Epo pathway[20]
  •   Eponfkb pathway[12]
  •   Erk pathway[29]
  •   Erk5 pathway[19]
  •   Eryth pathway[16]
  •   Etc pathway[13]
  •   Ets pathway[19]
  •   Extrinsic pathway[14]
  •   Fas pathway[31]
  •   Fcer1 pathway[42]
  •   Feeder pathway[10]
  •   Fibrinolysis pathway[13]
  •   Fmlp pathway[40]
  •   Free pathway[11]
  •   G1 pathway[29]
  •   G2 pathway[25]
  •   Gaba pathway[11]
  •   Gata3 pathway[17]
  •   Gcr pathway[23]
  •   Gh pathway[29]
  •   Gleevec pathway[24]
  •   Glycolysis pathway[11]
  •   Gpcr pathway[38]
  •   Granulocytes pathway[15]
  •   Gsk3 pathway[28]
  •   Hcmv pathway[18]
  •   Hdac pathway[33]
  •   Her2 pathway[23]
  •   Hif pathway[16]
  •   Hivnef pathway[59]
  •   Hsp27 pathway[16]
  •   Igf1 pathway[22]
  •   Igf1mtor pathway[21]
  •   Igf1r pathway[24]
  •   Il10 pathway[18]
  •   Il12 pathway[24]
  •   Il17 pathway[18]
  •   Il1r pathway[34]
  •   Il2 pathway[23]
  •   Il22bp pathway[17]
  •   Il2rb pathway[39]
  •   Il3 pathway[16]
  •   Il4 pathway[12]
  •   Il5 pathway[11]
  •   Il6 pathway[23]
  •   Il7 pathway[18]
  •   Inflam pathway[30]
  •   Insulin pathway[23]
  •   Integrin pathway[39]
  •   Intrinsic pathway[24]
  •   Keratinocyte pathway[47]
  •   Kreb pathway[9]
  •   Lair pathway[18]
  •   Lectin pathway[13]
  •   Leptin pathway[12]
  •   Longevity pathway[16]
  •   Lym pathway[12]
  •   Mal pathway[20]
  •   Mapk pathway[88]
  •   Mcalpain pathway[26]
  •   Mcm pathway[19]
  •   Mef2d pathway[24]
  •   Met pathway[38]
  •   Mitochondria pathway[22]
  •   Monocyte pathway[12]
  •   Mpr pathway[35]
  •   Mta3 pathway[20]
  •   Mtor pathway[24]
  •   Myosin pathway[32]
  •   Ndkdynamin pathway[22]
  •   Neurotransmitters pathway[7]
  •   Nfat pathway[57]
  •   Nfkb pathway[24]
  •   Ngf pathway[19]
  •   Nkcells pathway[21]
  •   Nkt pathway[30]
  •   No1 pathway[34]
  •   No2il12 pathway[18]
  •   Nos1 pathway[25]
  •   Nthi pathway[25]
  •   Nuclearrs pathway[16]
  •   P27 pathway[14]
  •   P35alzheimers pathway[12]
  •   P38mapk pathway[41]
  •   P53 pathway[17]
  •   P53hypoxia pathway[24]
  •   Par1 pathway[38]
  •   Parkin pathway[14]
  •   Pdgf pathway[33]
  •   Pgc1a pathway[27]
  •   Pitx2 pathway[16]
  •   Plateletapp pathway[15]
  •   Plce pathway[13]
  •   Pml pathway[18]
  •   Ppara pathway[59]
  •   Proteasome pathway[29]
  •   Ps1 pathway[15]
  •   Ptc1 pathway[12]
  •   Ptdins pathway[24]
  •   Pten pathway[19]
  •   Pyk2 pathway[32]
  •   Rab pathway[13]
  •   Rac1 pathway[24]
  •   Raccycd pathway[27]
  •   Rankl pathway[15]
  •   Ranms pathway[11]
  •   Rarrxr pathway[16]
  •   Ras pathway[24]
  •   Rb pathway[14]
  •   Rela pathway[17]
  •   Rho pathway[33]
  •   Rna pathway[11]
  •   Salmonella pathway[14]
  •   Sars pathway[11]
  •   Set pathway[12]
  •   Shh pathway[17]
  •   Skp2e2f pathway[11]
  •   Sodd pathway[11]
  •   Sppa pathway[23]
  •   Spry pathway[19]
  •   Srcrptp pathway[12]
  •   Stathmin pathway[20]
  •   Stem pathway[16]
  •   Stress pathway[26]
  •   Tall1 pathway[16]
  •   Tcapoptosis pathway[12]
  •   Tcr pathway[50]
  •   Tcra pathway[14]
  •   Tcytotoxic pathway[15]
  •   Tel pathway[19]
  •   Tff pathway[22]
  •   Tgfb pathway[20]
  •   Th1th2 pathway[20]
  •   Thelper pathway[15]
  •   Tid pathway[20]
  •   Tnfr1 pathway[30]
  •   Tnfr2 pathway[19]
  •   Tob1 pathway[22]
  •   Toll pathway[38]
  •   Tpo pathway[25]
  •   Trka pathway[13]
  •   Ucalpain pathway[19]
  •   Vdr pathway[13]
  •   Vegf pathway[30]
  •   Vip pathway[30]
  •   Vitcb pathway[12]
  •   Wnt pathway[27]
KEGG Pathway
  •   Abc transporters[45]
  •   Acute myeloid leukemia[61]
  •   Adherens junction[76]
  •   Adipocytokine signaling pathway[68]
  •   Alanine aspartate and glutamate metabolism[33]
  •   Aldosterone regulated sodium reabsorption[43]
  •   Allograft rejection[39]
  •   Alpha linolenic acid metabolism[20]
  •   Alzheimers disease[170]
  •   Amino sugar and nucleotide sugar metabolism[45]
  •   Aminoacyl trna biosynthesis[42]
  •   Amyotrophic lateral sclerosis als[54]
  •   Antigen processing and presentation[90]
  •   Apoptosis[89]
  •   Arachidonic acid metabolism[59]
  •   Arginine and proline metabolism[55]
  •   Arrhythmogenic right ventricular cardiomyopathy arvc[77]
  •   Ascorbate and aldarate metabolism[26]
  •   Asthma[31]
  •   Autoimmune thyroid disease[54]
  •   Axon guidance[130]
  •   B cell receptor signaling pathway[76]
  •   Basal cell carcinoma[56]
  •   Basal transcription factors[37]
  •   Base excision repair[36]
  •   Beta alanine metabolism[23]
  •   Biosynthesis of unsaturated fatty acids[23]
  •   Bladder cancer[43]
  •   Butanoate metabolism[35]
  •   Calcium signaling pathway[179]
  •   Cardiac muscle contraction[81]
  •   Cell adhesion molecules cams[135]
  •   Cell cycle[129]
  •   Chemokine signaling pathway[191]
  •   Chronic myeloid leukemia[74]
  •   Circadian rhythm mammal[14]
  •   Citrate cycle tca cycle[33]
  •   Colorectal cancer[63]
  •   Complement and coagulation cascades[70]
  •   Cysteine and methionine metabolism[35]
  •   Cytokine cytokine receptor interaction[268]
  •   Cytosolic dna sensing pathway[57]
  •   Dilated cardiomyopathy[93]
  •   Dna replication[37]
  •   Dorso ventral axis formation[26]
  •   Drug metabolism cytochrome p450[73]
  •   Drug metabolism other enzymes[52]
  •   Ecm receptor interaction[85]
  •   Endocytosis[184]
  •   Endometrial cancer[53]
  •   Epithelial cell signaling in helicobacter pylori infection[69]
  •   Erbb signaling pathway[88]
  •   Ether lipid metabolism[34]
  •   Fatty acid metabolism[43]
  •   Fc epsilon ri signaling pathway[80]
  •   Fc gamma r mediated phagocytosis[98]
  •   Focal adhesion[202]
  •   Folate biosynthesis[12]
  •   Fructose and mannose metabolism[35]
  •   Galactose metabolism[27]
  •   Gap junction[91]
  •   Glioma[66]
  •   Glutathione metabolism[51]
  •   Glycerolipid metabolism[50]
  •   Glycerophospholipid metabolism[78]
  •   Glycine serine and threonine metabolism[32]
  •   Glycolysis gluconeogenesis[63]
  •   Glycosaminoglycan biosynthesis chondroitin sulfate[23]
  •   Glycosaminoglycan biosynthesis heparan sulfate[27]
  •   Glycosaminoglycan biosynthesis keratan sulfate[16]
  •   Glycosaminoglycan degradation[22]
  •   Glycosphingolipid biosynthesis ganglio series[16]
  •   Glycosphingolipid biosynthesis globo series[15]
  •   Glycosphingolipid biosynthesis lacto and neolacto series[27]
  •   Glycosylphosphatidylinositol gpi anchor biosynthesis[26]
  •   Glyoxylate and dicarboxylate metabolism[17]
  •   Gnrh signaling pathway[102]
  •   Graft versus host disease[43]
  •   Hedgehog signaling pathway[57]
  •   Hematopoietic cell lineage[89]
  •   Histidine metabolism[30]
  •   Homologous recombination[29]
  •   Huntingtons disease[186]
  •   Hypertrophic cardiomyopathy hcm[86]
  •   Inositol phosphate metabolism[55]
  •   Insulin signaling pathway[138]
  •   Intestinal immune network for iga production[49]
  •   Jak stat signaling pathway[156]
  •   Leishmania infection[73]
  •   Leukocyte transendothelial migration[119]
  •   Limonene and pinene degradation[11]
  •   Linoleic acid metabolism[30]
  •   Long term depression[71]
  •   Long term potentiation[71]
  •   Lysine degradation[45]
  •   Lysosome[122]
  •   Mapk signaling pathway[268]
  •   Maturity onset diabetes of the young[26]
  •   Melanogenesis[103]
  •   Melanoma[72]
  •   Metabolism of xenobiotics by cytochrome p450[71]
  •   Mismatch repair[24]
  •   Mtor signaling pathway[53]
  •   N glycan biosynthesis[47]
  •   Natural killer cell mediated cytotoxicity[138]
  •   Neuroactive ligand receptor interaction[273]
  •   Neurotrophin signaling pathway[127]
  •   Nicotinate and nicotinamide metabolism[25]
  •   Nitrogen metabolism[24]
  •   Nod like receptor signaling pathway[63]
  •   Non homologous end joining[15]
  •   Non small cell lung cancer[55]
  •   Notch signaling pathway[48]
  •   Nucleotide excision repair[45]
  •   O glycan biosynthesis[31]
  •   Olfactory transduction[390]
  •   One carbon pool by folate[18]
  •   Oocyte meiosis[115]
  •   Other glycan degradation[17]
  •   Oxidative phosphorylation[136]
  •   P53 signaling pathway[70]
  •   Pancreatic cancer[71]
  •   Pantothenate and coa biosynthesis[17]
  •   Parkinsons disease[134]
  •   Pathogenic escherichia coli infection[60]
  •   Pathways in cancer[329]
  •   Pentose and glucuronate interconversions[29]
  •   Pentose phosphate pathway[28]
  •   Peroxisome[79]
  •   Phenylalanine metabolism[19]
  •   Phosphatidylinositol signaling system[77]
  •   Porphyrin and chlorophyll metabolism[42]
  •   Ppar signaling pathway[70]
  •   Primary bile acid biosynthesis[17]
  •   Primary immunodeficiency[36]
  •   Prion diseases[36]
  •   Progesterone mediated oocyte maturation[87]
  •   Propanoate metabolism[34]
  •   Prostate cancer[90]
  •   Proteasome[49]
  •   Protein export[25]
  •   Proximal tubule bicarbonate reclamation[24]
  •   Purine metabolism[160]
  •   Pyrimidine metabolism[99]
  •   Pyruvate metabolism[41]
  •   Regulation of actin cytoskeleton[217]
  •   Regulation of autophagy[36]
  •   Renal cell carcinoma[71]
  •   Renin angiotensin system[18]
  •   Retinol metabolism[65]
  •   Riboflavin metabolism[17]
  •   Ribosome[89]
  •   Rig i like receptor signaling pathway[72]
  •   Rna degradation[60]
  •   Rna polymerase[30]
  •   Selenoamino acid metabolism[27]
  •   Small cell lung cancer[85]
  •   Snare interactions in vesicular transport[39]
  •   Sphingolipid metabolism[41]
  •   Spliceosome[129]
  •   Starch and sucrose metabolism[53]
  •   Steroid biosynthesis[18]
  •   Steroid hormone biosynthesis[56]
  •   Sulfur metabolism[14]
  •   Systemic lupus erythematosus[141]
  •   T cell receptor signaling pathway[109]
  •   Taste transduction[53]
  •   Taurine and hypotaurine metabolism[11]
  •   Terpenoid backbone biosynthesis[16]
  •   Tgf beta signaling pathway[87]
  •   Thyroid cancer[30]
  •   Tight junction[135]
  •   Toll like receptor signaling pathway[103]
  •   Tryptophan metabolism[41]
  •   Type i diabetes mellitus[45]
  •   Type ii diabetes mellitus[48]
  •   Tyrosine metabolism[43]
  •   Ubiquitin mediated proteolysis[139]
  •   Valine leucine and isoleucine biosynthesis[12]
  •   Valine leucine and isoleucine degradation[45]
  •   Vascular smooth muscle contraction[116]
  •   Vasopressin regulated water reabsorption[45]
  •   Vegf signaling pathway[77]
  •   Vibrio cholerae infection[57]
  •   Viral myocarditis[74]
  •   Wnt signaling pathway[152]
Reactome Pathway
  •   3 utr mediated translational regulation[177]
  •   A tetrasaccharide linker sequence is required for gag synthesis[26]
  •   Abacavir transport and metabolism[11]
  •   Abc family proteins mediated transport[35]
  •   Abca transporters in lipid homeostasis[19]
  •   Abortive elongation of hiv1 transcript in the absence of tat[24]
  •   Acetylcholine binding and downstream events[17]
  •   Acetylcholine neurotransmitter release cycle[11]
  •   Activated ampk stimulates fatty acid oxidation in muscle[20]
  •   Activated notch1 transmits signal to the nucleus[28]
  •   Activated point mutants of fgfr2[17]
  •   Activated tak1 mediates p38 mapk activation[19]
  •   Activated tlr4 signalling[94]
  •   Activation of atr in response to replication stress[39]
  •   Activation of bh3 only proteins[18]
  •   Activation of chaperone genes by atf6 alpha[12]
  •   Activation of chaperone genes by xbp1s[47]
  •   Activation of chaperones by atf6 alpha[14]
  •   Activation of genes by atf4[27]
  •   Activation of irf3 irf7 mediated by tbk1 ikk epsilon[15]
  •   Activation of kainate receptors upon glutamate binding[32]
  •   Activation of nf kappab in b cells[65]
  •   Activation of nmda receptor upon glutamate binding and postsynaptic events[38]
  •   Activation of rac[15]
  •   Activation of the ap1 family of transcription factors[11]
  •   Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s[85]
  •   Activation of the pre replicative complex[32]
  •   Acyl chain remodelling of pc[23]
  •   Acyl chain remodelling of pe[22]
  •   Acyl chain remodelling of pg[17]
  •   Acyl chain remodelling of pi[16]
  •   Acyl chain remodelling of ps[16]
  •   Adaptive immune system[540]
  •   Adenylate cyclase activating pathway[11]
  •   Adenylate cyclase inhibitory pathway[14]
  •   Adherens junctions interactions[28]
  •   Adp signalling through p2ry1[26]
  •   Adp signalling through p2ry12[22]
  •   Advanced glycosylation endproduct receptor signaling[14]
  •   Akt phosphorylates targets in the cytosol[13]
  •   Alpha linolenic acid ala metabolism[13]
  •   Amine compound slc transporters[28]
  •   Amine derived hormones[16]
  •   Amine ligand binding receptors[39]
  •   Amino acid and oligopeptide slc transporters[50]
  •   Amino acid synthesis and interconversion transamination[18]
  •   Amino acid transport across the plasma membrane[32]
  •   Amyloids[84]
  •   Androgen biosynthesis[11]
  •   Antigen activates b cell receptor leading to generation of second messengers[30]
  •   Antigen presentation folding assembly and peptide loading of class i mhc[22]
  •   Antigen processing cross presentation[77]
  •   Antigen processing ubiquitination proteasome degradation[213]
  •   Antiviral mechanism by ifn stimulated genes[67]
  •   Apc c cdc20 mediated degradation of cyclin b[27]
  •   Apc c cdc20 mediated degradation of mitotic proteins[74]
  •   Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1[73]
  •   Apc cdc20 mediated degradation of nek2a[29]
  •   Apobec3g mediated resistance to hiv1 infection[13]
  •   Apoptosis[149]
  •   Apoptosis induced dna fragmentation[14]
  •   Apoptotic cleavage of cell adhesion proteins[13]
  •   Apoptotic cleavage of cellular proteins[41]
  •   Apoptotic execution phase[55]
  •   Aquaporin mediated transport[52]
  •   Arms mediated activation[18]
  •   Asparagine n linked glycosylation[82]
  •   Assembly of the pre replicative complex[66]
  •   Association of licensing factors with the pre replicative complex[15]
  •   Association of tric cct with target proteins during biosynthesis[28]
  •   Autodegradation of cdh1 by cdh1 apc c[65]
  •   Autodegradation of the e3 ubiquitin ligase cop1[52]
  •   Axon guidance[252]
  •   Base excision repair[20]
  •   Base free sugar phosphate removal via the single nucleotide replacement pathway[11]
  •   Basigin interactions[31]
  •   Beta defensins[43]
  •   Bile acid and bile salt metabolism[28]
  •   Bile salt and organic anion slc transporters[12]
  •   Binding and entry of hiv virion[11]
  •   Biological oxidations[140]
  •   Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein[30]
  •   Bmal1 clock npas2 activates circadian expression[37]
  •   Botulinum neurotoxicity[20]
  •   Branched chain amino acid catabolism[18]
  •   Ca dependent events[31]
  •   Calnexin calreticulin cycle[12]
  •   Caspase mediated cleavage of cytoskeletal proteins[14]
  •   Cd28 co stimulation[33]
  •   Cd28 dependent pi3k akt signaling[23]
  •   Cd28 dependent vav1 pathway[12]
  •   Cdc6 association with the orc origin complex[12]
  •   Cdk mediated phosphorylation and removal of cdc6[49]
  •   Cdt1 association with the cdc6 orc origin complex[57]
  •   Cell cell communication[121]
  •   Cell cell junction organization[57]
  •   Cell cycle[422]
  •   Cell cycle checkpoints[125]
  •   Cell cycle mitotic[326]
  •   Cell death signalling via nrage nrif and nade[61]
  •   Cell extracellular matrix interactions[15]
  •   Cell junction organization[79]
  •   Cell surface interactions at the vascular wall[92]
  •   Cgmp effects[20]
  •   Chemokine receptors bind chemokines[58]
  •   Cholesterol biosynthesis[25]
  •   Chondroitin sulfate biosynthesis[22]
  •   Chondroitin sulfate dermatan sulfate metabolism[50]
  •   Chromosome maintenance[123]
  •   Chylomicron mediated lipid transport[17]
  •   Circadian clock[54]
  •   Circadian repression of expression by rev erba[24]
  •   Citric acid cycle tca cycle[27]
  •   Class a1 rhodopsin like receptors[306]
  •   Class b 2 secretin family receptors[89]
  •   Class c 3 metabotropic glutamate pheromone receptors[16]
  •   Class i mhc mediated antigen processing presentation[252]
  •   Cleavage of growing transcript in the termination region [45]
  •   Collagen formation[59]
  •   Common pathway[15]
  •   Complement cascade[33]
  •   Conversion from apc c cdc20 to apc c cdh1 in late anaphase[23]
  •   Copi mediated transport[11]
  •   Costimulation by the cd28 family[64]
  •   Creation of c4 and c2 activators[11]
  •   Creb phosphorylation through the activation of camkii[16]
  •   Creb phosphorylation through the activation of ras[28]
  •   Crmps in sema3a signaling[15]
  •   Cross presentation of soluble exogenous antigens endosomes[49]
  •   Cs ds degradation[13]
  •   Ctla4 inhibitory signaling[22]
  •   Ctnnb1 phosphorylation cascade[17]
  •   Cyclin a b1 associated events during g2 m transition[16]
  •   Cyclin e associated events during g1 s transition [66]
  •   Cytochrome p450 arranged by substrate type[52]
  •   Cytokine signaling in immune system[271]
  •   Cytosolic sulfonation of small molecules[15]
  •   Cytosolic trna aminoacylation[25]
  •   Dag and ip3 signaling[33]
  •   Darpp 32 events[26]
  •   Dcc mediated attractive signaling[14]
  •   Deadenylation dependent mrna decay[49]
  •   Deadenylation of mrna[23]
  •   Defensins[52]
  •   Degradation of the extracellular matrix[30]
  •   Deposition of new cenpa containing nucleosomes at the centromere[65]
  •   Destabilization of mrna by auf1 hnrnp d0[54]
  •   Destabilization of mrna by brf1[18]
  •   Destabilization of mrna by ksrp[18]
  •   Destabilization of mrna by tristetraprolin ttp[18]
  •   Developmental biology[397]
  •   Diabetes pathways[134]
  •   Digestion of dietary carbohydrate[13]
  •   Dna repair[113]
  •   Dna replication[193]
  •   Dna strand elongation[31]
  •   Dopamine neurotransmitter release cycle[12]
  •   Double strand break repair[25]
  •   Downregulation of erbb2 erbb3 signaling[13]
  •   Downregulation of smad2 3 smad4 transcriptional activity[21]
  •   Downregulation of tgf beta receptor signaling[24]
  •   Downstream signal transduction[96]
  •   Downstream signaling events of b cell receptor bcr[98]
  •   Downstream signaling of activated fgfr[101]
  •   Downstream tcr signaling[38]
  •   Dscam interactions[12]
  •   E2f enabled inhibition of pre replication complex formation[11]
  •   E2f mediated regulation of dna replication[36]
  •   Early phase of hiv life cycle[22]
  •   Effects of pip2 hydrolysis[26]
  •   Egfr downregulation[26]
  •   Eicosanoid ligand binding receptors[17]
  •   Elevation of cytosolic ca2 levels[11]
  •   Elongation arrest and recovery[33]
  •   Endogenous sterols[16]
  •   Endosomal sorting complex required for transport escrt[28]
  •   Endosomal vacuolar pathway[10]
  •   Energy dependent regulation of mtor by lkb1 ampk[19]
  •   Enos activation and regulation[21]
  •   Er phagosome pathway[62]
  •   Erk mapk targets[22]
  •   Erks are inactivated[13]
  •   Ethanol oxidation[11]
  •   Extension of telomeres[28]
  •   Extracellular matrix organization[88]
  •   Extrinsic pathway for apoptosis[14]
  •   Facilitative na independent glucose transporters[13]
  •   Factors involved in megakaryocyte development and platelet production[133]
  •   Fanconi anemia pathway[26]
  •   Fatty acid triacylglycerol and ketone body metabolism[169]
  •   Fatty acyl coa biosynthesis[19]
  •   Fgfr ligand binding and activation[23]
  •   Fgfr1 ligand binding and activation[15]
  •   Fgfr2c ligand binding and activation[13]
  •   Fgfr4 ligand binding and activation[13]
  •   Formation of atp by chemiosmotic coupling[17]
  •   Formation of fibrin clot clotting cascade[33]
  •   Formation of incision complex in gg ner[24]
  •   Formation of rna pol ii elongation complex [46]
  •   Formation of the hiv1 early elongation complex[35]
  •   Formation of the ternary complex and subsequently the 43s complex[75]
  •   Formation of transcription coupled ner tc ner repair complex[31]
  •   Formation of tubulin folding intermediates by cct tric[23]
  •   Frs2 mediated cascade[37]
  •   G alpha i signalling events[196]
  •   G alpha q signalling events[185]
  •   G alpha s signalling events[122]
  •   G alpha z signalling events[45]
  •   G alpha1213 signalling events[75]
  •   G beta gamma signalling through pi3kgamma[26]
  •   G beta gamma signalling through plc beta[21]
  •   G protein activation[28]
  •   G protein beta gamma signalling[29]
  •   G0 and early g1[26]
  •   G1 phase[39]
  •   G1 s specific transcription[20]
  •   G1 s transition[113]
  •   G2 m checkpoints[46]
  •   G2 m dna damage checkpoint[13]
  •   Gab1 signalosome[39]
  •   Gaba a receptor activation[13]
  •   Gaba b receptor activation[39]
  •   Gaba receptor activation[53]
  •   Gaba synthesis release reuptake and degradation[18]
  •   Gamma carboxylation transport and amino terminal cleavage of proteins[12]
  •   Gap junction assembly[19]
  •   Gap junction degradation[11]
  •   Gap junction trafficking[28]
  •   Gastrin creb signalling pathway via pkc and mapk[206]
  •   Generation of second messenger molecules[28]
  •   Generic transcription pathway[353]
  •   Global genomic ner gg ner[36]
  •   Glucagon signaling in metabolic regulation[35]
  •   Glucagon type ligand receptors[34]
  •   Gluconeogenesis[35]
  •   Glucose metabolism[70]
  •   Glucose transport[39]
  •   Glucuronidation[19]
  •   Glutamate neurotransmitter release cycle[16]
  •   Glutathione conjugation[24]
  •   Glycerophospholipid biosynthesis[83]
  •   Glycogen breakdown glycogenolysis[19]
  •   Glycolysis[30]
  •   Glycoprotein hormones[13]
  •   Glycosaminoglycan metabolism[112]
  •   Glycosphingolipid metabolism[39]
  •   Golgi associated vesicle biogenesis[54]
  •   Gpcr downstream signaling[806]
  •   Gpcr ligand binding[409]
  •   Gpvi mediated activation cascade[32]
  •   Grb2 events in erbb2 signaling[23]
  •   Grb2 sos provides linkage to mapk signaling for intergrins [16]
  •   Growth hormone receptor signaling[25]
  •   Hdl mediated lipid transport[16]
  •   Hemostasis[467]
  •   Heparan sulfate heparin hs gag metabolism[53]
  •   Highly calcium permeable postsynaptic nicotinic acetylcholine receptors[14]
  •   Hiv infection[208]
  •   Hiv life cycle[126]
  •   Homologous recombination repair of replication independent double strand breaks[18]
  •   Hormone ligand binding receptors[11]
  •   Hormone sensitive lipase hsl mediated triacylglycerol hydrolysis[14]
  •   Host interactions of hiv factors[133]
  •   Hs gag biosynthesis[32]
  •   Hs gag degradation[21]
  •   Hyaluronan metabolism[15]
  •   Hyaluronan uptake and degradation[11]
  •   Ikk complex recruitment mediated by rip1[11]
  •   Il 2 signaling[42]
  •   Il 3 5 and gm csf signaling[44]
  •   Il 6 signaling[12]
  •   Il 7 signaling[12]
  •   Il receptor shc signaling[28]
  •   Il1 signaling[40]
  •   Immune system[934]
  •   Immunoregulatory interactions between a lymphoid and a non lymphoid cell[71]
  •   Incretin synthesis secretion and inactivation[23]
  •   Inflammasomes[18]
  •   Influenza life cycle[204]
  •   Influenza viral rna transcription and replication[170]
  •   Inhibition of insulin secretion by adrenaline noradrenaline[26]
  •   Inhibition of replication initiation of damaged dna by rb1 e2f1[14]
  •   Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components[25]
  •   Inhibition of voltage gated ca2 channels via gbeta gamma subunits[26]
  •   Initial triggering of complement[17]
  •   Innate immune system[280]
  •   Insulin receptor recycling[24]
  •   Insulin receptor signalling cascade[88]
  •   Insulin synthesis and processing[22]
  •   Integration of energy metabolism[121]
  •   Integration of provirus[17]
  •   Integrin alphaiib beta3 signaling[28]
  •   Integrin cell surface interactions[80]
  •   Interaction between l1 and ankyrins[24]
  •   Interactions of vpr with host cellular proteins[34]
  •   Interferon alpha beta signaling[65]
  •   Interferon gamma signaling[64]
  •   Interferon signaling[160]
  •   Intrinsic pathway[18]
  •   Intrinsic pathway for apoptosis[31]
  •   Inwardly rectifying k channels[32]
  •   Ion channel transport[56]
  •   Ion transport by p type atpases[35]
  •   Ionotropic activity of kainate receptors[12]
  •   Irak1 recruits ikk complex[11]
  •   Irak2 mediated activation of tak1 complex upon tlr7 8 or 9 stimulation[10]
  •   Iron uptake and transport[37]
  •   Jnk c jun kinases phosphorylation and activation mediated by activated human tak1[17]
  •   Keratan sulfate biosynthesis[27]
  •   Keratan sulfate degradation[12]
  •   Keratan sulfate keratin metabolism[31]
  •   Kinesins[25]
  •   L1cam interactions[87]
  •   Lagging strand synthesis[20]
  •   Late phase of hiv life cycle[105]
  •   Latent infection of homo sapiens with mycobacterium tuberculosis[34]
  •   Ligand gated ion channel transport[22]
  •   Lipid digestion mobilization and transport[47]
  •   Lipoprotein metabolism[29]
  •   Loss of nlp from mitotic centrosomes[60]
  •   Lysosome vesicle biogenesis[24]
  •   M g1 transition[82]
  •   Map kinase activation in tlr cascade[51]
  •   Mapk targets nuclear events mediated by map kinases[31]
  •   Meiosis[117]
  •   Meiotic recombination[87]
  •   Meiotic synapsis[74]
  •   Membrane binding and targetting of gag proteins[11]
  •   Membrane trafficking[130]
  •   Metabolism of amino acids and derivatives[201]
  •   Metabolism of carbohydrates[248]
  •   Metabolism of lipids and lipoproteins[479]
  •   Metabolism of mrna[285]
  •   Metabolism of non coding rna[50]
  •   Metabolism of nucleotides[73]
  •   Metabolism of polyamines[16]
  •   Metabolism of porphyrins[15]
  •   Metabolism of proteins[519]
  •   Metabolism of rna[331]
  •   Metabolism of steroid hormones and vitamins a and d[36]
  •   Metabolism of vitamins and cofactors[52]
  •   Metal ion slc transporters[23]
  •   Mhc class ii antigen presentation[92]
  •   Microrna mirna biogenesis[24]
  •   Mitochondrial fatty acid beta oxidation[15]
  •   Mitochondrial protein import[59]
  •   Mitochondrial trna aminoacylation[22]
  •   Mitotic g1 g1 s phases[138]
  •   Mitotic g2 g2 m phases[82]
  •   Mitotic m m g1 phases[173]
  •   Mitotic prometaphase[88]
  •   Mrna 3 end processing[36]
  •   Mrna capping[31]
  •   Mrna decay by 3 to 5 exoribonuclease[12]
  •   Mrna decay by 5 to 3 exoribonuclease[16]
  •   Mrna processing[162]
  •   Mrna splicing[112]
  •   Mrna splicing minor pathway[46]
  •   Mtorc1 mediated signalling[12]
  •   Muscle contraction[49]
  •   Myd88 mal cascade initiated on plasma membrane[84]
  •   Myogenesis[29]
  •   N glycan antennae elongation[15]
  •   N glycan antennae elongation in the medial trans golgi[19]
  •   N glycan trimming in the er and calnexin calreticulin cycle[14]
  •   Na cl dependent neurotransmitter transporters[18]
  •   Ncam signaling for neurite out growth[65]
  •   Ncam1 interactions[40]
  •   Nef mediated downregulation of mhc class i complex cell surface expression[11]
  •   Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters[22]
  •   Negative regulation of fgfr signaling[38]
  •   Negative regulation of the pi3k akt network[10]
  •   Negative regulators of rig i mda5 signaling[32]
  •   Nep ns2 interacts with the cellular export machinery[28]
  •   Nephrin interactions[21]
  •   Netrin1 signaling[42]
  •   Neuronal system[280]
  •   Neurotransmitter receptor binding and downstream transmission in the postsynaptic cell[138]
  •   Neurotransmitter release cycle[35]
  •   Nfkb activation through fadd rip1 pathway mediated by caspase 8 and10[13]
  •   Nfkb and map kinases activation mediated by tlr4 signaling repertoire[73]
  •   Nfkb is activated and signals survival[12]
  •   Ngf signalling via trka from the plasma membrane[138]
  •   Nitric oxide stimulates guanylate cyclase[26]
  •   Nod1 2 signaling pathway[31]
  •   Nonsense mediated decay enhanced by the exon junction complex[177]
  •   Norepinephrine neurotransmitter release cycle[11]
  •   Notch hlh transcription pathway[14]
  •   Notch1 intracellular domain regulates transcription[47]
  •   Nrage signals death through jnk[44]
  •   Nrif signals cell death from the nucleus[16]
  •   Nuclear events kinase and transcription factor activation[25]
  •   Nuclear receptor transcription pathway[50]
  •   Nuclear signaling by erbb4[39]
  •   Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways[47]
  •   Nucleotide excision repair[52]
  •   Nucleotide like purinergic receptors[17]
  •   O linked glycosylation of mucins[60]
  •   Olfactory signaling pathway[329]
  •   Opioid signalling[79]
  •   Opsins[11]
  •   Orc1 removal from chromatin[68]
  •   Organic cation anion zwitterion transport[14]
  •   Other semaphorin interactions[16]
  •   Oxygen dependent proline hydroxylation of hypoxia inducible factor alpha[19]
  •   P130cas linkage to mapk signaling for integrins[16]
  •   P2y receptors[13]
  •   P38mapk events[14]
  •   P53 dependent g1 dna damage response[58]
  •   P53 independent g1 s dna damage checkpoint[52]
  •   P75 ntr receptor mediated signalling[82]
  •   P75ntr recruits signalling complexes[13]
  •   P75ntr signals via nfkb[15]
  •   Packaging of telomere ends[49]
  •   Passive transport by aquaporins[12]
  •   Pd1 signaling[19]
  •   Pecam1 interactions[11]
  •   Peptide chain elongation[154]
  •   Peptide hormone biosynthesis[15]
  •   Peptide ligand binding receptors[189]
  •   Perk regulated gene expression[30]
  •   Peroxisomal lipid metabolism[22]
  •   Phase ii conjugation[71]
  •   Phase1 functionalization of compounds[71]
  •   Phospholipase c mediated cascade[55]
  •   Phospholipid metabolism[199]
  •   Phosphorylation of cd3 and tcr zeta chains[17]
  •   Phosphorylation of the apc c[24]
  •   Pi 3k cascade[57]
  •   Pi metabolism[49]
  •   Pi3k akt activation[39]
  •   Pi3k cascade[72]
  •   Pi3k events in erbb2 signaling[45]
  •   Pi3k events in erbb4 signaling[39]
  •   Pip3 activates akt signaling[30]
  •   Pka mediated phosphorylation of creb[19]
  •   Pkb mediated events[30]
  •   Platelet activation signaling and aggregation[209]
  •   Platelet adhesion to exposed collagen[13]
  •   Platelet aggregation plug formation[37]
  •   Platelet calcium homeostasis[19]
  •   Platelet homeostasis[79]
  •   Platelet sensitization by ldl[17]
  •   Plc beta mediated events[44]
  •   Pol switching[14]
  •   Post chaperonin tubulin folding pathway[20]
  •   Post nmda receptor activation events[34]
  •   Post translational modification synthesis of gpi anchored proteins[27]
  •   Post translational protein modification[189]
  •   Potassium channels[99]
  •   Ppara activates gene expression[105]
  •   Pre notch expression and processing[45]
  •   Pre notch processing in golgi[17]
  •   Pre notch transcription and translation[30]
  •   Prefoldin mediated transfer of substrate to cct tric[29]
  •   Presynaptic nicotinic acetylcholine receptors[13]
  •   Processing of capped intron containing pre mrna[141]
  •   Processing of capped intronless pre mrna[24]
  •   Processing of intronless pre mrnas[15]
  •   Processive synthesis on the lagging strand[16]
  •   Prolactin receptor signaling[15]
  •   Prolonged erk activation events[20]
  •   Prostacyclin signalling through prostacyclin receptor[20]
  •   Prostanoid ligand receptors[11]
  •   Protein folding[54]
  •   Proteolytic cleavage of snare complex proteins[18]
  •   Ptm gamma carboxylation hypusine formation and arylsulfatase activation[28]
  •   Purine catabolism[11]
  •   Purine metabolism[34]
  •   Purine ribonucleoside monophosphate biosynthesis[12]
  •   Purine salvage[14]
  •   Pyrimidine catabolism[13]
  •   Pyrimidine metabolism[25]
  •   Pyruvate metabolism[20]
  •   Pyruvate metabolism and citric acid tca cycle[49]
  •   Raf map kinase cascade[11]
  •   Rap1 signalling[18]
  •   Ras activation uopn ca2 infux through nmda receptor[18]
  •   Receptor ligand binding initiates the second proteolytic cleavage of notch receptor[13]
  •   Recruitment of mitotic centrosome proteins and complexes[67]
  •   Recruitment of numa to mitotic centrosomes[11]
  •   Recycling of bile acids and salts[12]
  •   Recycling pathway of l1[28]
  •   Regulated proteolysis of p75ntr[11]
  •   Regulation of ampk activity via lkb1[16]
  •   Regulation of apoptosis[59]
  •   Regulation of beta cell development[31]
  •   Regulation of complement cascade[15]
  •   Regulation of gene expression in beta cells[21]
  •   Regulation of glucokinase by glucokinase regulatory protein[28]
  •   Regulation of hypoxia inducible factor hif by oxygen[26]
  •   Regulation of ifna signaling[25]
  •   Regulation of ifng signaling[15]
  •   Regulation of insulin like growth factor igf activity by insulin like growth factor binding proteins igfbps[17]
  •   Regulation of insulin secretion[94]
  •   Regulation of insulin secretion by acetylcholine[12]
  •   Regulation of insulin secretion by glucagon like peptide1[44]
  •   Regulation of kit signaling[18]
  •   Regulation of mitotic cell cycle[86]
  •   Regulation of mrna stability by proteins that bind au rich elements[85]
  •   Regulation of ornithine decarboxylase odc[50]
  •   Regulation of pyruvate dehydrogenase pdh complex[14]
  •   Regulation of rheb gtpase activity by ampk[11]
  •   Regulation of signaling by cbl[19]
  •   Regulation of the fanconi anemia pathway[12]
  •   Regulation of water balance by renal aquaporins[45]
  •   Regulatory rna pathways[27]
  •   Removal of the flap intermediate from the c strand[11]
  •   Repair synthesis for gap filling by dna pol in tc ner[15]
  •   Resolution of ap sites via the multiple nucleotide patch replacement pathway[18]
  •   Resolution of ap sites via the single nucleotide replacement pathway[13]
  •   Respiratory electron transport[80]
  •   Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins [99]
  •   Response to elevated platelet cytosolic ca2 [90]
  •   Retrograde neurotrophin signalling[14]
  •   Reversible hydration of carbon dioxide[13]
  •   Rig i mda5 mediated induction of ifn alpha beta pathways[74]
  •   Rip mediated nfkb activation via dai[19]
  •   Rna pol i promoter opening[63]
  •   Rna pol i rna pol iii and mitochondrial transcription[123]
  •   Rna pol i transcription[90]
  •   Rna pol i transcription initiation[26]
  •   Rna pol i transcription termination[23]
  •   Rna pol ii pre transcription events[62]
  •   Rna pol ii transcription[106]
  •   Rna pol ii transcription pre initiation and promoter opening[42]
  •   Rna pol iii chain elongation[18]
  •   Rna pol iii transcription[34]
  •   Rna pol iii transcription initiation from type 2 promoter[24]
  •   Rna pol iii transcription initiation from type 3 promoter[27]
  •   Rna pol iii transcription termination[20]
  •   Role of dcc in regulating apoptosis[11]
  •   Role of second messengers in netrin1 signaling[12]
  •   Rora activates circadian expression[25]
  •   S phase[110]
  •   Scf beta trcp mediated degradation of emi1[52]
  •   Scfskp2 mediated degradation of p27 p21[57]
  •   Sema3a pak dependent axon repulsion[16]
  •   Sema3a plexin repulsion signaling by inhibiting integrin adhesion[14]
  •   Sema4d in semaphorin signaling[33]
  •   Sema4d induced cell migration and growth cone collapse[28]
  •   Semaphorin interactions[69]
  •   Serotonin receptors[13]
  •   Shc mediated cascade[29]
  •   Shc mediated signalling[16]
  •   Shc related events[18]
  •   Shc1 events in egfr signaling[16]
  •   Shc1 events in erbb4 signaling[21]
  •   Signal amplification[32]
  •   Signal attenuation[15]
  •   Signal regulatory protein sirp family interactions[13]
  •   Signal transduction by l1[35]
  •   Signaling by activated point mutants of fgfr1[12]
  •   Signaling by bmp[24]
  •   Signaling by constitutively active egfr[19]
  •   Signaling by egfr in cancer[110]
  •   Signaling by erbb2[102]
  •   Signaling by erbb4[91]
  •   Signaling by fgfr[113]
  •   Signaling by fgfr in disease[128]
  •   Signaling by fgfr mutants[45]
  •   Signaling by fgfr1 fusion mutants[20]
  •   Signaling by fgfr1 mutants[31]
  •   Signaling by fgfr3 mutants[12]
  •   Signaling by gpcr[921]
  •   Signaling by hippo[23]
  •   Signaling by ils[108]
  •   Signaling by insulin receptor[109]
  •   Signaling by nodal[19]
  •   Signaling by notch[104]
  •   Signaling by notch1[71]
  •   Signaling by notch2[13]
  •   Signaling by notch3[13]
  •   Signaling by notch4[13]
  •   Signaling by pdgf[123]
  •   Signaling by rho gtpases[114]
  •   Signaling by robo receptor[31]
  •   Signaling by scf kit[79]
  •   Signaling by tgf beta receptor complex[64]
  •   Signaling by the b cell receptor bcr[127]
  •   Signaling by wnt[66]
  •   Signalling by ngf[218]
  •   Signalling to erks[37]
  •   Signalling to p38 via rit and rin[16]
  •   Signalling to ras[28]
  •   Slbp dependent processing of replication dependent histone pre mrnas[12]
  •   Slc mediated transmembrane transport[242]
  •   Smad2 smad3 smad4 heterotrimer regulates transcription[28]
  •   Smooth muscle contraction[26]
  •   Sos mediated signalling[15]
  •   Sphingolipid de novo biosynthesis[32]
  •   Sphingolipid metabolism[70]
  •   Spry regulation of fgf signaling[15]
  •   Srp dependent cotranslational protein targeting to membrane[180]
  •   Steroid hormones[30]
  •   Striated muscle contraction[28]
  •   Sulfur amino acid metabolism[25]
  •   Synthesis and interconversion of nucleotide di and triphosphates[20]
  •   Synthesis of bile acids and bile salts[20]
  •   Synthesis of bile acids and bile salts via 24 hydroxycholesterol[11]
  •   Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol[16]
  •   Synthesis of dna[93]
  •   Synthesis of glycosylphosphatidylinositol gpi[18]
  •   Synthesis of pa[28]
  •   Synthesis of pc[19]
  •   Synthesis of pe[12]
  •   Synthesis of pips at the early endosome membrane[13]
  •   Synthesis of pips at the golgi membrane[18]
  •   Synthesis of pips at the late endosome membrane[11]
  •   Synthesis of pips at the plasma membrane[32]
  •   Synthesis of substrates in n glycan biosythesis[15]
  •   Synthesis of very long chain fatty acyl coas[15]
  •   Synthesis secretion and deacylation of ghrelin[17]
  •   Synthesis secretion and inactivation of gip[15]
  •   Synthesis secretion and inactivation of glp1[20]
  •   Tak1 activates nfkb by phosphorylation and activation of ikks complex[24]
  •   Tandem pore domain potassium channels[13]
  •   Tca cycle and respiratory electron transport[142]
  •   Tcr signaling[55]
  •   Telomere maintenance[76]
  •   Termination of o glycan biosynthesis[25]
  •   Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation[14]
  •   Tgf beta receptor signaling activates smads[27]
  •   Tgf beta receptor signaling in emt epithelial to mesenchymal transition[17]
  •   The activation of arylsulfatases[13]
  •   The nlrp3 inflammasome[13]
  •   The role of nef in hiv1 replication and disease pathogenesis[29]
  •   Thrombin signalling through proteinase activated receptors pars[33]
  •   Thromboxane signalling through tp receptor[24]
  •   Tie2 signaling[18]
  •   Tight junction interactions[30]
  •   Toll receptor cascades[119]
  •   Traf3 dependent irf activation pathway[15]
  •   Traf6 mediated induction of nfkb and map kinases upon tlr7 8 or 9 activation[78]
  •   Traf6 mediated induction of tak1 complex[15]
  •   Traf6 mediated irf7 activation[31]
  •   Traf6 mediated irf7 activation in tlr7 8 or 9 signaling[11]
  •   Traf6 mediated nfkb activation[22]
  •   Trafficking and processing of endosomal tlr[15]
  •   Trafficking of ampa receptors[29]
  •   Trafficking of glur2 containing ampa receptors[17]
  •   Trans golgi network vesicle budding[61]
  •   Transcription[211]
  •   Transcription coupled ner tc ner[46]
  •   Transcriptional activity of smad2 smad3 smad4 heterotrimer[39]
  •   Transcriptional regulation of white adipocyte differentiation[73]
  •   Transferrin endocytosis and recycling[26]
  •   Translation[223]
  •   Translocation of zap 70 to immunological synapse[15]
  •   Transmembrane transport of small molecules[414]
  •   Transmission across chemical synapses[187]
  •   Transport of glucose and other sugars bile salts and organic acids metal ions and amine compounds[90]
  •   Transport of inorganic cations anions and amino acids oligopeptides[95]
  •   Transport of mature mrna derived from an intronless transcript[34]
  •   Transport of mature transcript to cytoplasm[55]
  •   Transport of organic anions[12]
  •   Transport of ribonucleoproteins into the host nucleus[28]
  •   Transport of vitamins nucleosides and related molecules[32]
  •   Transport to the golgi and subsequent modification[34]
  •   Trif mediated tlr3 signaling[75]
  •   Triglyceride biosynthesis[39]
  •   Trna aminoacylation[43]
  •   Tryptophan catabolism[12]
  •   Unblocking of nmda receptor glutamate binding and activation[16]
  •   Unfolded protein response[81]
  •   Unwinding of dna[12]
  •   Vegf ligand receptor interactions[11]
  •   Vif mediated degradation of apobec3g[53]
  •   Viral messenger rna synthesis[15]
  •   Vitamin b5 pantothenate metabolism[12]
  •   Voltage gated potassium channels[44]
  •   Xenobiotics[17]
  •   Yap1 and wwtr1 taz stimulated gene expression[25]
  •   Zinc transporters[16]
Sample Grouping
A renal allograft biopsy /diagnosis: ABMR
1 GSM880212 ABMR18diagnosis: ABMR
2 GSM880214 ABMR19diagnosis: ABMR
3 GSM880216 ABMR20diagnosis: ABMR
4 GSM880217 ABMR21diagnosis: ABMR
5 GSM880218 ABMR22diagnosis: ABMR
6 GSM880229 ABMR23diagnosis: ABMR
7 GSM880233 ABMR1diagnosis: ABMR
8 GSM880236 ABMR24diagnosis: ABMR
9 GSM880237 ABMR25diagnosis: ABMR
10 GSM880239 ABMR26diagnosis: ABMR
11 GSM880248 ABMR27diagnosis: ABMR
12 GSM880249 ABMR28diagnosis: ABMR
13 GSM880251 ABMR29diagnosis: ABMR
14 GSM880258 ABMR2diagnosis: ABMR
15 GSM880259 ABMR30diagnosis: ABMR
16 GSM880264 ABMR3diagnosis: ABMR
17 GSM880270 ABMR31diagnosis: ABMR
18 GSM880275 ABMR4diagnosis: ABMR
19 GSM880276 ABMR32diagnosis: ABMR
20 GSM880286 ABMR33diagnosis: ABMR
21 GSM880287 ABMR34diagnosis: ABMR
22 GSM880288 ABMR35diagnosis: ABMR
23 GSM880289 ABMR36diagnosis: ABMR
24 GSM880291 ABMR37diagnosis: ABMR
25 GSM880294 ABMR38diagnosis: ABMR
26 GSM880297 ABMR39diagnosis: ABMR
27 GSM880304 ABMR40diagnosis: ABMR
28 GSM880305 ABMR41diagnosis: ABMR
29 GSM880306 ABMR42diagnosis: ABMR
30 GSM880313 ABMR43diagnosis: ABMR
31 GSM880317 ABMR44diagnosis: ABMR
32 GSM880333 ABMR45diagnosis: ABMR
33 GSM880334 ABMR46diagnosis: ABMR
34 GSM880335 ABMR47diagnosis: ABMR
35 GSM880353 ABMR48diagnosis: ABMR
36 GSM880370 ABMR5diagnosis: ABMR
37 GSM880374 ABMR6diagnosis: ABMR
38 GSM880397 ABMR49diagnosis: ABMR
39 GSM880405 ABMR50diagnosis: ABMR
40 GSM880408 ABMR7diagnosis: ABMR
41 GSM880420 ABMR51diagnosis: ABMR
42 GSM880424 ABMR52diagnosis: ABMR
43 GSM880428 ABMR53diagnosis: ABMR
44 GSM880429 ABMR54diagnosis: ABMR
45 GSM880436 ABMR8diagnosis: ABMR
46 GSM880442 ABMR55diagnosis: ABMR
47 GSM880449 ABMR56diagnosis: ABMR
48 GSM880453 ABMR57diagnosis: ABMR
49 GSM880466 ABMR9diagnosis: ABMR
50 GSM880477 ABMR10diagnosis: ABMR
51 GSM880503 ABMR11diagnosis: ABMR
52 GSM880517 ABMR12diagnosis: ABMR
53 GSM880519 ABMR58diagnosis: ABMR
54 GSM880521 ABMR59diagnosis: ABMR
55 GSM880529 ABMR60diagnosis: ABMR
56 GSM880531 ABMR13diagnosis: ABMR
57 GSM880535 ABMR61diagnosis: ABMR
58 GSM880565 ABMR62diagnosis: ABMR
59 GSM880573 ABMR63diagnosis: ABMR
60 GSM880591 ABMR14diagnosis: ABMR
61 GSM880596 ABMR15diagnosis: ABMR
62 GSM880602 ABMR64diagnosis: ABMR
63 GSM880605 ABMR16diagnosis: ABMR
64 GSM880606 ABMR17diagnosis: ABMR
65 GSM880612 ABMR65diagnosis: ABMR
B renal allograft biopsy /diagnosis: MIXED
1 GSM880228 MIXED1diagnosis: MIXED
2 GSM880230 MIXED2diagnosis: MIXED
3 GSM880244 MIXED3diagnosis: MIXED
4 GSM880250 MIXED4diagnosis: MIXED
5 GSM880260 MIXED5diagnosis: MIXED
6 GSM880261 MIXED6diagnosis: MIXED
7 GSM880271 MIXED7diagnosis: MIXED
8 GSM880273 MIXED8diagnosis: MIXED
9 GSM880302 MIXED9diagnosis: MIXED
10 GSM880314 MIXED10diagnosis: MIXED
11 GSM880352 MIXED11diagnosis: MIXED
12 GSM880391 MIXED12diagnosis: MIXED
13 GSM880395 MIXED13diagnosis: MIXED
14 GSM880407 MIXED14diagnosis: MIXED
15 GSM880437 MIXED15diagnosis: MIXED
16 GSM880459 MIXED16diagnosis: MIXED
17 GSM880502 MIXED17diagnosis: MIXED
18 GSM880505 MIXED18diagnosis: MIXED
19 GSM880506 MIXED19diagnosis: MIXED
20 GSM880512 MIXED20diagnosis: MIXED
21 GSM880601 MIXED21diagnosis: MIXED
22 GSM880611 MIXED22diagnosis: MIXED
C nephrectomy /diagnosis: Nephrectomy
1 GSM880245 Nephrectomy1diagnosis: Nephrectomy
2 GSM880246 Nephrectomy2diagnosis: Nephrectomy
3 GSM880299 Nephrectomy3diagnosis: Nephrectomy
4 GSM880311 Nephrectomy4diagnosis: Nephrectomy
5 GSM880318 Nephrectomy5diagnosis: Nephrectomy
6 GSM880430 Nephrectomy6diagnosis: Nephrectomy
7 GSM880447 Nephrectomy7diagnosis: Nephrectomy
8 GSM880500 Nephrectomy8diagnosis: Nephrectomy
D renal allograft biopsy /diagnosis: non-rejecting
1 GSM880204 non-rejecting146diagnosis: non-rejecting
2 GSM880205 non-rejecting63diagnosis: non-rejecting
3 GSM880206 non-rejecting252diagnosis: non-rejecting
4 GSM880207 non-rejecting180diagnosis: non-rejecting
5 GSM880208 non-rejecting181diagnosis: non-rejecting
6 GSM880209 non-rejecting182diagnosis: non-rejecting
7 GSM880210 non-rejecting147diagnosis: non-rejecting
8 GSM880211 non-rejecting183diagnosis: non-rejecting
9 GSM880213 non-rejecting1diagnosis: non-rejecting
10 GSM880219 non-rejecting148diagnosis: non-rejecting
11 GSM880220 non-rejecting2diagnosis: non-rejecting
12 GSM880221 non-rejecting3diagnosis: non-rejecting
13 GSM880222 non-rejecting64diagnosis: non-rejecting
14 GSM880223 non-rejecting184diagnosis: non-rejecting
15 GSM880224 non-rejecting105diagnosis: non-rejecting
16 GSM880225 non-rejecting4diagnosis: non-rejecting
17 GSM880226 non-rejecting185diagnosis: non-rejecting
18 GSM880227 non-rejecting5diagnosis: non-rejecting
19 GSM880231 non-rejecting6diagnosis: non-rejecting
20 GSM880232 non-rejecting65diagnosis: non-rejecting
21 GSM880235 non-rejecting186diagnosis: non-rejecting
22 GSM880238 non-rejecting149diagnosis: non-rejecting
23 GSM880241 non-rejecting150diagnosis: non-rejecting
24 GSM880242 non-rejecting151diagnosis: non-rejecting
25 GSM880243 non-rejecting152diagnosis: non-rejecting
26 GSM880247 non-rejecting106diagnosis: non-rejecting
27 GSM880252 non-rejecting7diagnosis: non-rejecting
28 GSM880253 non-rejecting66diagnosis: non-rejecting
29 GSM880254 non-rejecting8diagnosis: non-rejecting
30 GSM880255 non-rejecting107diagnosis: non-rejecting
31 GSM880256 non-rejecting108diagnosis: non-rejecting
32 GSM880257 non-rejecting109diagnosis: non-rejecting
33 GSM880262 non-rejecting110diagnosis: non-rejecting
34 GSM880263 non-rejecting67diagnosis: non-rejecting
35 GSM880265 non-rejecting153diagnosis: non-rejecting
36 GSM880266 non-rejecting187diagnosis: non-rejecting
37 GSM880267 non-rejecting154diagnosis: non-rejecting
38 GSM880268 non-rejecting111diagnosis: non-rejecting
39 GSM880269 non-rejecting253diagnosis: non-rejecting
40 GSM880272 non-rejecting272diagnosis: non-rejecting
41 GSM880274 non-rejecting188diagnosis: non-rejecting
42 GSM880277 non-rejecting155diagnosis: non-rejecting
43 GSM880278 non-rejecting9diagnosis: non-rejecting
44 GSM880279 non-rejecting10diagnosis: non-rejecting
45 GSM880281 non-rejecting273diagnosis: non-rejecting
46 GSM880282 non-rejecting112diagnosis: non-rejecting
47 GSM880283 non-rejecting11diagnosis: non-rejecting
48 GSM880284 non-rejecting189diagnosis: non-rejecting
49 GSM880285 non-rejecting190diagnosis: non-rejecting
50 GSM880290 non-rejecting191diagnosis: non-rejecting
51 GSM880292 non-rejecting156diagnosis: non-rejecting
52 GSM880293 non-rejecting68diagnosis: non-rejecting
53 GSM880295 non-rejecting113diagnosis: non-rejecting
54 GSM880296 non-rejecting114diagnosis: non-rejecting
55 GSM880298 non-rejecting69diagnosis: non-rejecting
56 GSM880300 non-rejecting192diagnosis: non-rejecting
57 GSM880301 non-rejecting274diagnosis: non-rejecting
58 GSM880303 non-rejecting157diagnosis: non-rejecting
59 GSM880308 non-rejecting70diagnosis: non-rejecting
60 GSM880310 non-rejecting193diagnosis: non-rejecting
61 GSM880312 non-rejecting12diagnosis: non-rejecting
62 GSM880315 non-rejecting71diagnosis: non-rejecting
63 GSM880316 non-rejecting72diagnosis: non-rejecting
64 GSM880319 non-rejecting13diagnosis: non-rejecting
65 GSM880320 non-rejecting51diagnosis: non-rejecting
66 GSM880321 non-rejecting52diagnosis: non-rejecting
67 GSM880322 non-rejecting14diagnosis: non-rejecting
68 GSM880323 non-rejecting194diagnosis: non-rejecting
69 GSM880324 non-rejecting158diagnosis: non-rejecting
70 GSM880325 non-rejecting73diagnosis: non-rejecting
71 GSM880326 non-rejecting254diagnosis: non-rejecting
72 GSM880327 non-rejecting74diagnosis: non-rejecting
73 GSM880328 non-rejecting195diagnosis: non-rejecting
74 GSM880329 non-rejecting75diagnosis: non-rejecting
75 GSM880330 non-rejecting196diagnosis: non-rejecting
76 GSM880332 non-rejecting159diagnosis: non-rejecting
77 GSM880336 non-rejecting197diagnosis: non-rejecting
78 GSM880337 non-rejecting198diagnosis: non-rejecting
79 GSM880338 non-rejecting160diagnosis: non-rejecting
80 GSM880339 non-rejecting255diagnosis: non-rejecting
81 GSM880340 non-rejecting199diagnosis: non-rejecting
82 GSM880342 non-rejecting161diagnosis: non-rejecting
83 GSM880343 non-rejecting15diagnosis: non-rejecting
84 GSM880344 non-rejecting200diagnosis: non-rejecting
85 GSM880347 non-rejecting201diagnosis: non-rejecting
86 GSM880348 non-rejecting76diagnosis: non-rejecting
87 GSM880349 non-rejecting115diagnosis: non-rejecting
88 GSM880350 non-rejecting16diagnosis: non-rejecting
89 GSM880351 non-rejecting116diagnosis: non-rejecting
90 GSM880354 non-rejecting77diagnosis: non-rejecting
91 GSM880355 non-rejecting117diagnosis: non-rejecting
92 GSM880356 non-rejecting162diagnosis: non-rejecting
93 GSM880357 non-rejecting118diagnosis: non-rejecting
94 GSM880358 non-rejecting119diagnosis: non-rejecting
95 GSM880359 non-rejecting256diagnosis: non-rejecting
96 GSM880360 non-rejecting257diagnosis: non-rejecting
97 GSM880361 non-rejecting17diagnosis: non-rejecting
98 GSM880362 non-rejecting258diagnosis: non-rejecting
99 GSM880363 non-rejecting202diagnosis: non-rejecting
100 GSM880364 non-rejecting120diagnosis: non-rejecting
101 GSM880365 non-rejecting18diagnosis: non-rejecting
102 GSM880366 non-rejecting259diagnosis: non-rejecting
103 GSM880367 non-rejecting260diagnosis: non-rejecting
104 GSM880368 non-rejecting19diagnosis: non-rejecting
105 GSM880369 non-rejecting203diagnosis: non-rejecting
106 GSM880371 non-rejecting20diagnosis: non-rejecting
107 GSM880373 non-rejecting21diagnosis: non-rejecting
108 GSM880375 non-rejecting22diagnosis: non-rejecting
109 GSM880376 non-rejecting204diagnosis: non-rejecting
110 GSM880377 non-rejecting23diagnosis: non-rejecting
111 GSM880378 non-rejecting261diagnosis: non-rejecting
112 GSM880379 non-rejecting205diagnosis: non-rejecting
113 GSM880380 non-rejecting53diagnosis: non-rejecting
114 GSM880381 non-rejecting24diagnosis: non-rejecting
115 GSM880382 non-rejecting25diagnosis: non-rejecting
116 GSM880383 non-rejecting26diagnosis: non-rejecting
117 GSM880384 non-rejecting262diagnosis: non-rejecting
118 GSM880385 non-rejecting206diagnosis: non-rejecting
119 GSM880386 non-rejecting121diagnosis: non-rejecting
120 GSM880387 non-rejecting207diagnosis: non-rejecting
121 GSM880389 non-rejecting78diagnosis: non-rejecting
122 GSM880390 non-rejecting208diagnosis: non-rejecting
123 GSM880392 non-rejecting209diagnosis: non-rejecting
124 GSM880393 non-rejecting27diagnosis: non-rejecting
125 GSM880396 non-rejecting122diagnosis: non-rejecting
126 GSM880398 non-rejecting123diagnosis: non-rejecting
127 GSM880400 non-rejecting124diagnosis: non-rejecting
128 GSM880401 non-rejecting79diagnosis: non-rejecting
129 GSM880402 non-rejecting275diagnosis: non-rejecting
130 GSM880403 non-rejecting210diagnosis: non-rejecting
131 GSM880404 non-rejecting28diagnosis: non-rejecting
132 GSM880406 non-rejecting276diagnosis: non-rejecting
133 GSM880409 non-rejecting277diagnosis: non-rejecting
134 GSM880410 non-rejecting278diagnosis: non-rejecting
135 GSM880412 non-rejecting211diagnosis: non-rejecting
136 GSM880413 non-rejecting125diagnosis: non-rejecting
137 GSM880414 non-rejecting212diagnosis: non-rejecting
138 GSM880415 non-rejecting126diagnosis: non-rejecting
139 GSM880417 non-rejecting163diagnosis: non-rejecting
140 GSM880418 non-rejecting127diagnosis: non-rejecting
141 GSM880419 non-rejecting80diagnosis: non-rejecting
142 GSM880421 non-rejecting81diagnosis: non-rejecting
143 GSM880422 non-rejecting29diagnosis: non-rejecting
144 GSM880423 non-rejecting82diagnosis: non-rejecting
145 GSM880425 non-rejecting30diagnosis: non-rejecting
146 GSM880427 non-rejecting213diagnosis: non-rejecting
147 GSM880431 non-rejecting54diagnosis: non-rejecting
148 GSM880432 non-rejecting214diagnosis: non-rejecting
149 GSM880433 non-rejecting215diagnosis: non-rejecting
150 GSM880435 non-rejecting216diagnosis: non-rejecting
151 GSM880438 non-rejecting128diagnosis: non-rejecting
152 GSM880439 non-rejecting129diagnosis: non-rejecting
153 GSM880441 non-rejecting130diagnosis: non-rejecting
154 GSM880443 non-rejecting131diagnosis: non-rejecting
155 GSM880444 non-rejecting132diagnosis: non-rejecting
156 GSM880446 non-rejecting83diagnosis: non-rejecting
157 GSM880448 non-rejecting84diagnosis: non-rejecting
158 GSM880450 non-rejecting164diagnosis: non-rejecting
159 GSM880451 non-rejecting279diagnosis: non-rejecting
160 GSM880452 non-rejecting133diagnosis: non-rejecting
161 GSM880454 non-rejecting31diagnosis: non-rejecting
162 GSM880455 non-rejecting263diagnosis: non-rejecting
163 GSM880457 non-rejecting134diagnosis: non-rejecting
164 GSM880458 non-rejecting165diagnosis: non-rejecting
165 GSM880460 non-rejecting135diagnosis: non-rejecting
166 GSM880461 non-rejecting32diagnosis: non-rejecting
167 GSM880462 non-rejecting33diagnosis: non-rejecting
168 GSM880463 non-rejecting85diagnosis: non-rejecting
169 GSM880467 non-rejecting280diagnosis: non-rejecting
170 GSM880468 non-rejecting217diagnosis: non-rejecting
171 GSM880469 non-rejecting86diagnosis: non-rejecting
172 GSM880470 non-rejecting87diagnosis: non-rejecting
173 GSM880471 non-rejecting218diagnosis: non-rejecting
174 GSM880472 non-rejecting55diagnosis: non-rejecting
175 GSM880473 non-rejecting219diagnosis: non-rejecting
176 GSM880474 non-rejecting136diagnosis: non-rejecting
177 GSM880475 non-rejecting137diagnosis: non-rejecting
178 GSM880476 non-rejecting220diagnosis: non-rejecting
179 GSM880478 non-rejecting221diagnosis: non-rejecting
180 GSM880479 non-rejecting88diagnosis: non-rejecting
181 GSM880480 non-rejecting222diagnosis: non-rejecting
182 GSM880481 non-rejecting223diagnosis: non-rejecting
183 GSM880482 non-rejecting56diagnosis: non-rejecting
184 GSM880483 non-rejecting57diagnosis: non-rejecting
185 GSM880486 non-rejecting89diagnosis: non-rejecting
186 GSM880487 non-rejecting90diagnosis: non-rejecting
187 GSM880488 non-rejecting91diagnosis: non-rejecting
188 GSM880489 non-rejecting92diagnosis: non-rejecting
189 GSM880491 non-rejecting264diagnosis: non-rejecting
190 GSM880494 non-rejecting166diagnosis: non-rejecting
191 GSM880495 non-rejecting167diagnosis: non-rejecting
192 GSM880496 non-rejecting224diagnosis: non-rejecting
193 GSM880497 non-rejecting138diagnosis: non-rejecting
194 GSM880498 non-rejecting93diagnosis: non-rejecting
195 GSM880499 non-rejecting34diagnosis: non-rejecting
196 GSM880501 non-rejecting225diagnosis: non-rejecting
197 GSM880504 non-rejecting35diagnosis: non-rejecting
198 GSM880507 non-rejecting168diagnosis: non-rejecting
199 GSM880508 non-rejecting226diagnosis: non-rejecting
200 GSM880509 non-rejecting36diagnosis: non-rejecting
201 GSM880510 non-rejecting227diagnosis: non-rejecting
202 GSM880511 non-rejecting169diagnosis: non-rejecting
203 GSM880513 non-rejecting37diagnosis: non-rejecting
204 GSM880514 non-rejecting94diagnosis: non-rejecting
205 GSM880515 non-rejecting170diagnosis: non-rejecting
206 GSM880516 non-rejecting171diagnosis: non-rejecting
207 GSM880518 non-rejecting228diagnosis: non-rejecting
208 GSM880520 non-rejecting229diagnosis: non-rejecting
209 GSM880522 non-rejecting172diagnosis: non-rejecting
210 GSM880523 non-rejecting230diagnosis: non-rejecting
211 GSM880524 non-rejecting95diagnosis: non-rejecting
212 GSM880525 non-rejecting231diagnosis: non-rejecting
213 GSM880526 non-rejecting281diagnosis: non-rejecting
214 GSM880527 non-rejecting232diagnosis: non-rejecting
215 GSM880528 non-rejecting233diagnosis: non-rejecting
216 GSM880532 non-rejecting38diagnosis: non-rejecting
217 GSM880533 non-rejecting234diagnosis: non-rejecting
218 GSM880534 non-rejecting139diagnosis: non-rejecting
219 GSM880536 non-rejecting235diagnosis: non-rejecting
220 GSM880537 non-rejecting58diagnosis: non-rejecting
221 GSM880538 non-rejecting59diagnosis: non-rejecting
222 GSM880539 non-rejecting60diagnosis: non-rejecting
223 GSM880540 non-rejecting265diagnosis: non-rejecting
224 GSM880541 non-rejecting236diagnosis: non-rejecting
225 GSM880542 non-rejecting237diagnosis: non-rejecting
226 GSM880543 non-rejecting96diagnosis: non-rejecting
227 GSM880544 non-rejecting238diagnosis: non-rejecting
228 GSM880545 non-rejecting61diagnosis: non-rejecting
229 GSM880546 non-rejecting97diagnosis: non-rejecting
230 GSM880547 non-rejecting140diagnosis: non-rejecting
231 GSM880548 non-rejecting141diagnosis: non-rejecting
232 GSM880549 non-rejecting98diagnosis: non-rejecting
233 GSM880550 non-rejecting239diagnosis: non-rejecting
234 GSM880551 non-rejecting142diagnosis: non-rejecting
235 GSM880552 non-rejecting62diagnosis: non-rejecting
236 GSM880553 non-rejecting266diagnosis: non-rejecting
237 GSM880554 non-rejecting267diagnosis: non-rejecting
238 GSM880555 non-rejecting39diagnosis: non-rejecting
239 GSM880556 non-rejecting40diagnosis: non-rejecting
240 GSM880557 non-rejecting41diagnosis: non-rejecting
241 GSM880558 non-rejecting240diagnosis: non-rejecting
242 GSM880559 non-rejecting99diagnosis: non-rejecting
243 GSM880560 non-rejecting173diagnosis: non-rejecting
244 GSM880561 non-rejecting42diagnosis: non-rejecting
245 GSM880562 non-rejecting43diagnosis: non-rejecting
246 GSM880563 non-rejecting44diagnosis: non-rejecting
247 GSM880566 non-rejecting174diagnosis: non-rejecting
248 GSM880567 non-rejecting241diagnosis: non-rejecting
249 GSM880568 non-rejecting45diagnosis: non-rejecting
250 GSM880569 non-rejecting242diagnosis: non-rejecting
251 GSM880571 non-rejecting243diagnosis: non-rejecting
252 GSM880572 non-rejecting244diagnosis: non-rejecting
253 GSM880574 non-rejecting245diagnosis: non-rejecting
254 GSM880575 non-rejecting246diagnosis: non-rejecting
255 GSM880577 non-rejecting268diagnosis: non-rejecting
256 GSM880578 non-rejecting46diagnosis: non-rejecting
257 GSM880579 non-rejecting47diagnosis: non-rejecting
258 GSM880580 non-rejecting175diagnosis: non-rejecting
259 GSM880582 non-rejecting48diagnosis: non-rejecting
260 GSM880583 non-rejecting247diagnosis: non-rejecting
261 GSM880585 non-rejecting269diagnosis: non-rejecting
262 GSM880586 non-rejecting100diagnosis: non-rejecting
263 GSM880587 non-rejecting248diagnosis: non-rejecting
264 GSM880588 non-rejecting176diagnosis: non-rejecting
265 GSM880589 non-rejecting177diagnosis: non-rejecting
266 GSM880590 non-rejecting178diagnosis: non-rejecting
267 GSM880592 non-rejecting270diagnosis: non-rejecting
268 GSM880593 non-rejecting249diagnosis: non-rejecting
269 GSM880594 non-rejecting250diagnosis: non-rejecting
270 GSM880595 non-rejecting49diagnosis: non-rejecting
271 GSM880597 non-rejecting179diagnosis: non-rejecting
272 GSM880598 non-rejecting50diagnosis: non-rejecting
273 GSM880599 non-rejecting251diagnosis: non-rejecting
274 GSM880600 non-rejecting143diagnosis: non-rejecting
275 GSM880603 non-rejecting101diagnosis: non-rejecting
276 GSM880604 non-rejecting102diagnosis: non-rejecting
277 GSM880607 non-rejecting144diagnosis: non-rejecting
278 GSM880608 non-rejecting145diagnosis: non-rejecting
279 GSM880609 non-rejecting271diagnosis: non-rejecting
280 GSM880610 non-rejecting103diagnosis: non-rejecting
281 GSM880613 non-rejecting104diagnosis: non-rejecting
E renal allograft biopsy /diagnosis: TCMR
1 GSM880215 TCMR1diagnosis: TCMR
2 GSM880234 TCMR2diagnosis: TCMR
3 GSM880240 TCMR3diagnosis: TCMR
4 GSM880280 TCMR4diagnosis: TCMR
5 GSM880307 TCMR5diagnosis: TCMR
6 GSM880309 TCMR6diagnosis: TCMR
7 GSM880331 TCMR7diagnosis: TCMR
8 GSM880341 TCMR8diagnosis: TCMR
9 GSM880345 TCMR9diagnosis: TCMR
10 GSM880346 TCMR10diagnosis: TCMR
11 GSM880372 TCMR11diagnosis: TCMR
12 GSM880388 TCMR12diagnosis: TCMR
13 GSM880394 TCMR13diagnosis: TCMR
14 GSM880399 TCMR14diagnosis: TCMR
15 GSM880411 TCMR15diagnosis: TCMR
16 GSM880416 TCMR16diagnosis: TCMR
17 GSM880426 TCMR17diagnosis: TCMR
18 GSM880434 TCMR18diagnosis: TCMR
19 GSM880440 TCMR19diagnosis: TCMR
20 GSM880445 TCMR20diagnosis: TCMR
21 GSM880456 TCMR21diagnosis: TCMR
22 GSM880464 TCMR22diagnosis: TCMR
23 GSM880465 TCMR23diagnosis: TCMR
24 GSM880484 TCMR24diagnosis: TCMR
25 GSM880485 TCMR25diagnosis: TCMR
26 GSM880490 TCMR26diagnosis: TCMR
27 GSM880492 TCMR27diagnosis: TCMR
28 GSM880493 TCMR28diagnosis: TCMR
29 GSM880530 TCMR29diagnosis: TCMR
30 GSM880564 TCMR30diagnosis: TCMR
31 GSM880570 TCMR31diagnosis: TCMR
32 GSM880576 TCMR32diagnosis: TCMR
33 GSM880581 TCMR33diagnosis: TCMR
34 GSM880584 TCMR34diagnosis: TCMR
35 GSM880614 TCMR35diagnosis: TCMR
Gene Information
Official Symbol
NOTCH1
Officical Full Name
notch 1
Primary Source
HGNC:7881
See related
MIM:190198 Ensembl:ENSG00000148400 HPRD:01827 Vega:OTTHUMG00000020935
Chromosome Location
9q34.3
Gene Type
protein-coding
Also known as
TAN1 hN1
External Sources
GUDMAP
Experiment Description
Accession
RGED36059
Type
Microarray
Summary
Histologic diagnosis of T cell-mediated rejection in kidney transplant biopsies has limited reproducibility because it is based on non-specific lesions using arbitrary rules that are subject to differing interpretations. We used microarray results from 403 indication biopsies previously given histologic diagnoses to develop a molecular classifier that assigned a molecular T cell-mediated rejection score to each biopsy. Independent assessment of the biopsies by multiple pathologists confirmed considerable disagreement on the presence of TCMR features: 79-88% accuracy and 35-69% sensitivity. The agreement of the molecular T cell-mediated rejection score with the histology diagnosis was similar to agreement among individual pathologists: accuracy 89%, sensitivity 51%. However, the score also predicted the consensus among pathologists, being highest when all agreed. Many discrepancies between the scores and the histologic diagnoses were in situations where histology is unreliable e.g. scarred biopsies. The score correlated with histologic lesions and gene sets associated with T cell-mediated rejection. The transcripts most often selected by the classifier were expressed in effector T cells, dendritic cells, or macrophages or inducible by interferon-gamma. Thus the T cell-mediated rejection score offers an objective assessment of kidney transplant biopsies, predicting the consensus opinion among multiple pathologists, and offering insights into underlying disease mechanisms. Antibody-mediated rejection is a major cause of kidney transplant failure, but the current diagnostic system misses most cases due to dependency on subjective non-standardized tests. We hypothesized that molecular features could provide a test to address this problem. We classified 403 biopsies by a reference standard based on microcirculation lesions and donor-specific HLA antibody, and used microarray analysis to develop a classifier that assigned each biopsy a score reflecting the probability of antibody-mediated rejection. The scores correlated with donor-specific antibody and histologic lesions: 42/45 biopsies with antibody-mediated rejection scores >0.5 had both donor-specific antibody and microcirculation lesions. Intermediate scores (0.2-0.5) were more ambiguous, but became more specific combined with donor-specific antibody. Compared to diagnoses based on histology-plus-donor-specific antibody, the scores had sensitivity 0.67; specificity 0.90. Donor-specific antibody improved the specificity to 0.97. The score correlated not only with diagnoses of individual pathologists but with the consensus among multiple pathologists. The classifier used transcripts expressed in endothelial cells (e.g. CDH13, DARC, ROBO4) and NK cells (e.g. CX3CR1, FGFBP2), as well as IFNG-inducible transcripts e.g. CXCL11. Thus the molecular phenotype of antibody-mediated rejection provides not only an objective test that predicts microcirculation lesions and donor-specific HLA antibody, but also offers mechanistic insights.
Experiment Platform
Affymetrix Human Genome U133 Plus 2.0 Array [HG-U133_Plus_2]
Data Source
GSE36059