PIK3CA Expression Profiles in Kidney Carcinoma

Tool Box: Similarity Analysis

Select from the Gene Set

Biocarta Pathway
  •   41bb pathway[18]
  •   Ace2 pathway[14]
  •   Ach pathway[17]
  •   Actiny pathway[21]
  •   Agpcr pathway[14]
  •   Agr pathway[37]
  •   Ahsp pathway[14]
  •   Akap13 pathway[13]
  •   Akap95 pathway[13]
  •   Akapcentrosome pathway[16]
  •   Akt pathway[23]
  •   Alk pathway[38]
  •   Ami pathway[21]
  •   Arap pathway[19]
  •   Arenrf2 pathway[14]
  •   Arf pathway[18]
  •   Asbcell pathway[13]
  •   At1r pathway[37]
  •   Atm pathway[21]
  •   Atrbrca pathway[22]
  •   Bad pathway[27]
  •   Barr mapk pathway[13]
  •   Barrestin pathway[11]
  •   Barrestin src pathway[16]
  •   Bcellsurvival pathway[17]
  •   Bcr pathway[38]
  •   Biopeptides pathway[46]
  •   Blymphocyte pathway[12]
  •   Cacam pathway[17]
  •   Calcineurin pathway[22]
  •   Cardiacegf pathway[19]
  •   Carm er pathway[36]
  •   Carm1 pathway[14]
  •   Caspase pathway[24]
  •   Cbl pathway[14]
  •   Ccr3 pathway[24]
  •   Ccr5 pathway[21]
  •   Cd40 pathway[16]
  •   Cdc42rac pathway[17]
  •   Cdk5 pathway[12]
  •   Cdmac pathway[17]
  •   Cell2cell pathway[15]
  •   Cellcycle pathway[24]
  •   Ceramide pathway[23]
  •   Cftr pathway[13]
  •   Chemical pathway[23]
  •   Chrebp2 pathway[43]
  •   Ck1 pathway[18]
  •   Classic pathway[15]
  •   Comp pathway[20]
  •   Creb pathway[28]
  •   Csk pathway[25]
  •   Ctcf pathway[24]
  •   Ctl pathway[16]
  •   Ctla4 pathway[22]
  •   Cxcr4 pathway[25]
  •   Cytokine pathway[23]
  •   D4gdi pathway[14]
  •   Dc pathway[23]
  •   Death pathway[34]
  •   Dnafragment pathway[11]
  •   Dream pathway[15]
  •   Ecm pathway[25]
  •   Edg1 pathway[28]
  •   Egf pathway[32]
  •   Egfr smrte pathway[12]
  •   Eif pathway[17]
  •   Eif2 pathway[12]
  •   Eif4 pathway[25]
  •   Epha4 pathway[11]
  •   Epo pathway[20]
  •   Eponfkb pathway[12]
  •   Erk pathway[29]
  •   Erk5 pathway[19]
  •   Eryth pathway[16]
  •   Etc pathway[13]
  •   Ets pathway[19]
  •   Extrinsic pathway[14]
  •   Fas pathway[31]
  •   Fcer1 pathway[42]
  •   Feeder pathway[10]
  •   Fibrinolysis pathway[13]
  •   Fmlp pathway[40]
  •   Free pathway[11]
  •   G1 pathway[29]
  •   G2 pathway[25]
  •   Gaba pathway[11]
  •   Gata3 pathway[17]
  •   Gcr pathway[23]
  •   Gh pathway[29]
  •   Gleevec pathway[24]
  •   Glycolysis pathway[11]
  •   Gpcr pathway[38]
  •   Granulocytes pathway[15]
  •   Gsk3 pathway[28]
  •   Hcmv pathway[18]
  •   Hdac pathway[33]
  •   Her2 pathway[23]
  •   Hif pathway[16]
  •   Hivnef pathway[59]
  •   Hsp27 pathway[16]
  •   Igf1 pathway[22]
  •   Igf1mtor pathway[21]
  •   Igf1r pathway[24]
  •   Il10 pathway[18]
  •   Il12 pathway[24]
  •   Il17 pathway[18]
  •   Il1r pathway[34]
  •   Il2 pathway[23]
  •   Il22bp pathway[17]
  •   Il2rb pathway[39]
  •   Il3 pathway[16]
  •   Il4 pathway[12]
  •   Il5 pathway[11]
  •   Il6 pathway[23]
  •   Il7 pathway[18]
  •   Inflam pathway[30]
  •   Insulin pathway[23]
  •   Integrin pathway[39]
  •   Intrinsic pathway[24]
  •   Keratinocyte pathway[47]
  •   Kreb pathway[9]
  •   Lair pathway[18]
  •   Lectin pathway[13]
  •   Leptin pathway[12]
  •   Longevity pathway[16]
  •   Lym pathway[12]
  •   Mal pathway[20]
  •   Mapk pathway[88]
  •   Mcalpain pathway[26]
  •   Mcm pathway[19]
  •   Mef2d pathway[24]
  •   Met pathway[38]
  •   Mitochondria pathway[22]
  •   Monocyte pathway[12]
  •   Mpr pathway[35]
  •   Mta3 pathway[20]
  •   Mtor pathway[24]
  •   Myosin pathway[32]
  •   Ndkdynamin pathway[22]
  •   Neurotransmitters pathway[7]
  •   Nfat pathway[57]
  •   Nfkb pathway[24]
  •   Ngf pathway[19]
  •   Nkcells pathway[21]
  •   Nkt pathway[30]
  •   No1 pathway[34]
  •   No2il12 pathway[18]
  •   Nos1 pathway[25]
  •   Nthi pathway[25]
  •   Nuclearrs pathway[16]
  •   P27 pathway[14]
  •   P35alzheimers pathway[12]
  •   P38mapk pathway[41]
  •   P53 pathway[17]
  •   P53hypoxia pathway[24]
  •   Par1 pathway[38]
  •   Parkin pathway[14]
  •   Pdgf pathway[33]
  •   Pgc1a pathway[27]
  •   Pitx2 pathway[16]
  •   Plateletapp pathway[15]
  •   Plce pathway[13]
  •   Pml pathway[18]
  •   Ppara pathway[59]
  •   Proteasome pathway[29]
  •   Ps1 pathway[15]
  •   Ptc1 pathway[12]
  •   Ptdins pathway[24]
  •   Pten pathway[19]
  •   Pyk2 pathway[32]
  •   Rab pathway[13]
  •   Rac1 pathway[24]
  •   Raccycd pathway[27]
  •   Rankl pathway[15]
  •   Ranms pathway[11]
  •   Rarrxr pathway[16]
  •   Ras pathway[24]
  •   Rb pathway[14]
  •   Rela pathway[17]
  •   Rho pathway[33]
  •   Rna pathway[11]
  •   Salmonella pathway[14]
  •   Sars pathway[11]
  •   Set pathway[12]
  •   Shh pathway[17]
  •   Skp2e2f pathway[11]
  •   Sodd pathway[11]
  •   Sppa pathway[23]
  •   Spry pathway[19]
  •   Srcrptp pathway[12]
  •   Stathmin pathway[20]
  •   Stem pathway[16]
  •   Stress pathway[26]
  •   Tall1 pathway[16]
  •   Tcapoptosis pathway[12]
  •   Tcr pathway[50]
  •   Tcra pathway[14]
  •   Tcytotoxic pathway[15]
  •   Tel pathway[19]
  •   Tff pathway[22]
  •   Tgfb pathway[20]
  •   Th1th2 pathway[20]
  •   Thelper pathway[15]
  •   Tid pathway[20]
  •   Tnfr1 pathway[30]
  •   Tnfr2 pathway[19]
  •   Tob1 pathway[22]
  •   Toll pathway[38]
  •   Tpo pathway[25]
  •   Trka pathway[13]
  •   Ucalpain pathway[19]
  •   Vdr pathway[13]
  •   Vegf pathway[30]
  •   Vip pathway[30]
  •   Vitcb pathway[12]
  •   Wnt pathway[27]
KEGG Pathway
  •   Abc transporters[45]
  •   Acute myeloid leukemia[61]
  •   Adherens junction[76]
  •   Adipocytokine signaling pathway[68]
  •   Alanine aspartate and glutamate metabolism[33]
  •   Aldosterone regulated sodium reabsorption[43]
  •   Allograft rejection[39]
  •   Alpha linolenic acid metabolism[20]
  •   Alzheimers disease[170]
  •   Amino sugar and nucleotide sugar metabolism[45]
  •   Aminoacyl trna biosynthesis[42]
  •   Amyotrophic lateral sclerosis als[54]
  •   Antigen processing and presentation[90]
  •   Apoptosis[89]
  •   Arachidonic acid metabolism[59]
  •   Arginine and proline metabolism[55]
  •   Arrhythmogenic right ventricular cardiomyopathy arvc[77]
  •   Ascorbate and aldarate metabolism[26]
  •   Asthma[31]
  •   Autoimmune thyroid disease[54]
  •   Axon guidance[130]
  •   B cell receptor signaling pathway[76]
  •   Basal cell carcinoma[56]
  •   Basal transcription factors[37]
  •   Base excision repair[36]
  •   Beta alanine metabolism[23]
  •   Biosynthesis of unsaturated fatty acids[23]
  •   Bladder cancer[43]
  •   Butanoate metabolism[35]
  •   Calcium signaling pathway[179]
  •   Cardiac muscle contraction[81]
  •   Cell adhesion molecules cams[135]
  •   Cell cycle[129]
  •   Chemokine signaling pathway[191]
  •   Chronic myeloid leukemia[74]
  •   Circadian rhythm mammal[14]
  •   Citrate cycle tca cycle[33]
  •   Colorectal cancer[63]
  •   Complement and coagulation cascades[70]
  •   Cysteine and methionine metabolism[35]
  •   Cytokine cytokine receptor interaction[268]
  •   Cytosolic dna sensing pathway[57]
  •   Dilated cardiomyopathy[93]
  •   Dna replication[37]
  •   Dorso ventral axis formation[26]
  •   Drug metabolism cytochrome p450[73]
  •   Drug metabolism other enzymes[52]
  •   Ecm receptor interaction[85]
  •   Endocytosis[184]
  •   Endometrial cancer[53]
  •   Epithelial cell signaling in helicobacter pylori infection[69]
  •   Erbb signaling pathway[88]
  •   Ether lipid metabolism[34]
  •   Fatty acid metabolism[43]
  •   Fc epsilon ri signaling pathway[80]
  •   Fc gamma r mediated phagocytosis[98]
  •   Focal adhesion[202]
  •   Folate biosynthesis[12]
  •   Fructose and mannose metabolism[35]
  •   Galactose metabolism[27]
  •   Gap junction[91]
  •   Glioma[66]
  •   Glutathione metabolism[51]
  •   Glycerolipid metabolism[50]
  •   Glycerophospholipid metabolism[78]
  •   Glycine serine and threonine metabolism[32]
  •   Glycolysis gluconeogenesis[63]
  •   Glycosaminoglycan biosynthesis chondroitin sulfate[23]
  •   Glycosaminoglycan biosynthesis heparan sulfate[27]
  •   Glycosaminoglycan biosynthesis keratan sulfate[16]
  •   Glycosaminoglycan degradation[22]
  •   Glycosphingolipid biosynthesis ganglio series[16]
  •   Glycosphingolipid biosynthesis globo series[15]
  •   Glycosphingolipid biosynthesis lacto and neolacto series[27]
  •   Glycosylphosphatidylinositol gpi anchor biosynthesis[26]
  •   Glyoxylate and dicarboxylate metabolism[17]
  •   Gnrh signaling pathway[102]
  •   Graft versus host disease[43]
  •   Hedgehog signaling pathway[57]
  •   Hematopoietic cell lineage[89]
  •   Histidine metabolism[30]
  •   Homologous recombination[29]
  •   Huntingtons disease[186]
  •   Hypertrophic cardiomyopathy hcm[86]
  •   Inositol phosphate metabolism[55]
  •   Insulin signaling pathway[138]
  •   Intestinal immune network for iga production[49]
  •   Jak stat signaling pathway[156]
  •   Leishmania infection[73]
  •   Leukocyte transendothelial migration[119]
  •   Limonene and pinene degradation[11]
  •   Linoleic acid metabolism[30]
  •   Long term depression[71]
  •   Long term potentiation[71]
  •   Lysine degradation[45]
  •   Lysosome[122]
  •   Mapk signaling pathway[268]
  •   Maturity onset diabetes of the young[26]
  •   Melanogenesis[103]
  •   Melanoma[72]
  •   Metabolism of xenobiotics by cytochrome p450[71]
  •   Mismatch repair[24]
  •   Mtor signaling pathway[53]
  •   N glycan biosynthesis[47]
  •   Natural killer cell mediated cytotoxicity[138]
  •   Neuroactive ligand receptor interaction[273]
  •   Neurotrophin signaling pathway[127]
  •   Nicotinate and nicotinamide metabolism[25]
  •   Nitrogen metabolism[24]
  •   Nod like receptor signaling pathway[63]
  •   Non homologous end joining[15]
  •   Non small cell lung cancer[55]
  •   Notch signaling pathway[48]
  •   Nucleotide excision repair[45]
  •   O glycan biosynthesis[31]
  •   Olfactory transduction[390]
  •   One carbon pool by folate[18]
  •   Oocyte meiosis[115]
  •   Other glycan degradation[17]
  •   Oxidative phosphorylation[136]
  •   P53 signaling pathway[70]
  •   Pancreatic cancer[71]
  •   Pantothenate and coa biosynthesis[17]
  •   Parkinsons disease[134]
  •   Pathogenic escherichia coli infection[60]
  •   Pathways in cancer[329]
  •   Pentose and glucuronate interconversions[29]
  •   Pentose phosphate pathway[28]
  •   Peroxisome[79]
  •   Phenylalanine metabolism[19]
  •   Phosphatidylinositol signaling system[77]
  •   Porphyrin and chlorophyll metabolism[42]
  •   Ppar signaling pathway[70]
  •   Primary bile acid biosynthesis[17]
  •   Primary immunodeficiency[36]
  •   Prion diseases[36]
  •   Progesterone mediated oocyte maturation[87]
  •   Propanoate metabolism[34]
  •   Prostate cancer[90]
  •   Proteasome[49]
  •   Protein export[25]
  •   Proximal tubule bicarbonate reclamation[24]
  •   Purine metabolism[160]
  •   Pyrimidine metabolism[99]
  •   Pyruvate metabolism[41]
  •   Regulation of actin cytoskeleton[217]
  •   Regulation of autophagy[36]
  •   Renal cell carcinoma[71]
  •   Renin angiotensin system[18]
  •   Retinol metabolism[65]
  •   Riboflavin metabolism[17]
  •   Ribosome[89]
  •   Rig i like receptor signaling pathway[72]
  •   Rna degradation[60]
  •   Rna polymerase[30]
  •   Selenoamino acid metabolism[27]
  •   Small cell lung cancer[85]
  •   Snare interactions in vesicular transport[39]
  •   Sphingolipid metabolism[41]
  •   Spliceosome[129]
  •   Starch and sucrose metabolism[53]
  •   Steroid biosynthesis[18]
  •   Steroid hormone biosynthesis[56]
  •   Sulfur metabolism[14]
  •   Systemic lupus erythematosus[141]
  •   T cell receptor signaling pathway[109]
  •   Taste transduction[53]
  •   Taurine and hypotaurine metabolism[11]
  •   Terpenoid backbone biosynthesis[16]
  •   Tgf beta signaling pathway[87]
  •   Thyroid cancer[30]
  •   Tight junction[135]
  •   Toll like receptor signaling pathway[103]
  •   Tryptophan metabolism[41]
  •   Type i diabetes mellitus[45]
  •   Type ii diabetes mellitus[48]
  •   Tyrosine metabolism[43]
  •   Ubiquitin mediated proteolysis[139]
  •   Valine leucine and isoleucine biosynthesis[12]
  •   Valine leucine and isoleucine degradation[45]
  •   Vascular smooth muscle contraction[116]
  •   Vasopressin regulated water reabsorption[45]
  •   Vegf signaling pathway[77]
  •   Vibrio cholerae infection[57]
  •   Viral myocarditis[74]
  •   Wnt signaling pathway[152]
Reactome Pathway
  •   3 utr mediated translational regulation[177]
  •   A tetrasaccharide linker sequence is required for gag synthesis[26]
  •   Abacavir transport and metabolism[11]
  •   Abc family proteins mediated transport[35]
  •   Abca transporters in lipid homeostasis[19]
  •   Abortive elongation of hiv1 transcript in the absence of tat[24]
  •   Acetylcholine binding and downstream events[17]
  •   Acetylcholine neurotransmitter release cycle[11]
  •   Activated ampk stimulates fatty acid oxidation in muscle[20]
  •   Activated notch1 transmits signal to the nucleus[28]
  •   Activated point mutants of fgfr2[17]
  •   Activated tak1 mediates p38 mapk activation[19]
  •   Activated tlr4 signalling[94]
  •   Activation of atr in response to replication stress[39]
  •   Activation of bh3 only proteins[18]
  •   Activation of chaperone genes by atf6 alpha[12]
  •   Activation of chaperone genes by xbp1s[47]
  •   Activation of chaperones by atf6 alpha[14]
  •   Activation of genes by atf4[27]
  •   Activation of irf3 irf7 mediated by tbk1 ikk epsilon[15]
  •   Activation of kainate receptors upon glutamate binding[32]
  •   Activation of nf kappab in b cells[65]
  •   Activation of nmda receptor upon glutamate binding and postsynaptic events[38]
  •   Activation of rac[15]
  •   Activation of the ap1 family of transcription factors[11]
  •   Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s[85]
  •   Activation of the pre replicative complex[32]
  •   Acyl chain remodelling of pc[23]
  •   Acyl chain remodelling of pe[22]
  •   Acyl chain remodelling of pg[17]
  •   Acyl chain remodelling of pi[16]
  •   Acyl chain remodelling of ps[16]
  •   Adaptive immune system[540]
  •   Adenylate cyclase activating pathway[11]
  •   Adenylate cyclase inhibitory pathway[14]
  •   Adherens junctions interactions[28]
  •   Adp signalling through p2ry1[26]
  •   Adp signalling through p2ry12[22]
  •   Advanced glycosylation endproduct receptor signaling[14]
  •   Akt phosphorylates targets in the cytosol[13]
  •   Alpha linolenic acid ala metabolism[13]
  •   Amine compound slc transporters[28]
  •   Amine derived hormones[16]
  •   Amine ligand binding receptors[39]
  •   Amino acid and oligopeptide slc transporters[50]
  •   Amino acid synthesis and interconversion transamination[18]
  •   Amino acid transport across the plasma membrane[32]
  •   Amyloids[84]
  •   Androgen biosynthesis[11]
  •   Antigen activates b cell receptor leading to generation of second messengers[30]
  •   Antigen presentation folding assembly and peptide loading of class i mhc[22]
  •   Antigen processing cross presentation[77]
  •   Antigen processing ubiquitination proteasome degradation[213]
  •   Antiviral mechanism by ifn stimulated genes[67]
  •   Apc c cdc20 mediated degradation of cyclin b[27]
  •   Apc c cdc20 mediated degradation of mitotic proteins[74]
  •   Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1[73]
  •   Apc cdc20 mediated degradation of nek2a[29]
  •   Apobec3g mediated resistance to hiv1 infection[13]
  •   Apoptosis[149]
  •   Apoptosis induced dna fragmentation[14]
  •   Apoptotic cleavage of cell adhesion proteins[13]
  •   Apoptotic cleavage of cellular proteins[41]
  •   Apoptotic execution phase[55]
  •   Aquaporin mediated transport[52]
  •   Arms mediated activation[18]
  •   Asparagine n linked glycosylation[82]
  •   Assembly of the pre replicative complex[66]
  •   Association of licensing factors with the pre replicative complex[15]
  •   Association of tric cct with target proteins during biosynthesis[28]
  •   Autodegradation of cdh1 by cdh1 apc c[65]
  •   Autodegradation of the e3 ubiquitin ligase cop1[52]
  •   Axon guidance[252]
  •   Base excision repair[20]
  •   Base free sugar phosphate removal via the single nucleotide replacement pathway[11]
  •   Basigin interactions[31]
  •   Beta defensins[43]
  •   Bile acid and bile salt metabolism[28]
  •   Bile salt and organic anion slc transporters[12]
  •   Binding and entry of hiv virion[11]
  •   Biological oxidations[140]
  •   Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein[30]
  •   Bmal1 clock npas2 activates circadian expression[37]
  •   Botulinum neurotoxicity[20]
  •   Branched chain amino acid catabolism[18]
  •   Ca dependent events[31]
  •   Calnexin calreticulin cycle[12]
  •   Caspase mediated cleavage of cytoskeletal proteins[14]
  •   Cd28 co stimulation[33]
  •   Cd28 dependent pi3k akt signaling[23]
  •   Cd28 dependent vav1 pathway[12]
  •   Cdc6 association with the orc origin complex[12]
  •   Cdk mediated phosphorylation and removal of cdc6[49]
  •   Cdt1 association with the cdc6 orc origin complex[57]
  •   Cell cell communication[121]
  •   Cell cell junction organization[57]
  •   Cell cycle[422]
  •   Cell cycle checkpoints[125]
  •   Cell cycle mitotic[326]
  •   Cell death signalling via nrage nrif and nade[61]
  •   Cell extracellular matrix interactions[15]
  •   Cell junction organization[79]
  •   Cell surface interactions at the vascular wall[92]
  •   Cgmp effects[20]
  •   Chemokine receptors bind chemokines[58]
  •   Cholesterol biosynthesis[25]
  •   Chondroitin sulfate biosynthesis[22]
  •   Chondroitin sulfate dermatan sulfate metabolism[50]
  •   Chromosome maintenance[123]
  •   Chylomicron mediated lipid transport[17]
  •   Circadian clock[54]
  •   Circadian repression of expression by rev erba[24]
  •   Citric acid cycle tca cycle[27]
  •   Class a1 rhodopsin like receptors[306]
  •   Class b 2 secretin family receptors[89]
  •   Class c 3 metabotropic glutamate pheromone receptors[16]
  •   Class i mhc mediated antigen processing presentation[252]
  •   Cleavage of growing transcript in the termination region [45]
  •   Collagen formation[59]
  •   Common pathway[15]
  •   Complement cascade[33]
  •   Conversion from apc c cdc20 to apc c cdh1 in late anaphase[23]
  •   Copi mediated transport[11]
  •   Costimulation by the cd28 family[64]
  •   Creation of c4 and c2 activators[11]
  •   Creb phosphorylation through the activation of camkii[16]
  •   Creb phosphorylation through the activation of ras[28]
  •   Crmps in sema3a signaling[15]
  •   Cross presentation of soluble exogenous antigens endosomes[49]
  •   Cs ds degradation[13]
  •   Ctla4 inhibitory signaling[22]
  •   Ctnnb1 phosphorylation cascade[17]
  •   Cyclin a b1 associated events during g2 m transition[16]
  •   Cyclin e associated events during g1 s transition [66]
  •   Cytochrome p450 arranged by substrate type[52]
  •   Cytokine signaling in immune system[271]
  •   Cytosolic sulfonation of small molecules[15]
  •   Cytosolic trna aminoacylation[25]
  •   Dag and ip3 signaling[33]
  •   Darpp 32 events[26]
  •   Dcc mediated attractive signaling[14]
  •   Deadenylation dependent mrna decay[49]
  •   Deadenylation of mrna[23]
  •   Defensins[52]
  •   Degradation of the extracellular matrix[30]
  •   Deposition of new cenpa containing nucleosomes at the centromere[65]
  •   Destabilization of mrna by auf1 hnrnp d0[54]
  •   Destabilization of mrna by brf1[18]
  •   Destabilization of mrna by ksrp[18]
  •   Destabilization of mrna by tristetraprolin ttp[18]
  •   Developmental biology[397]
  •   Diabetes pathways[134]
  •   Digestion of dietary carbohydrate[13]
  •   Dna repair[113]
  •   Dna replication[193]
  •   Dna strand elongation[31]
  •   Dopamine neurotransmitter release cycle[12]
  •   Double strand break repair[25]
  •   Downregulation of erbb2 erbb3 signaling[13]
  •   Downregulation of smad2 3 smad4 transcriptional activity[21]
  •   Downregulation of tgf beta receptor signaling[24]
  •   Downstream signal transduction[96]
  •   Downstream signaling events of b cell receptor bcr[98]
  •   Downstream signaling of activated fgfr[101]
  •   Downstream tcr signaling[38]
  •   Dscam interactions[12]
  •   E2f enabled inhibition of pre replication complex formation[11]
  •   E2f mediated regulation of dna replication[36]
  •   Early phase of hiv life cycle[22]
  •   Effects of pip2 hydrolysis[26]
  •   Egfr downregulation[26]
  •   Eicosanoid ligand binding receptors[17]
  •   Elevation of cytosolic ca2 levels[11]
  •   Elongation arrest and recovery[33]
  •   Endogenous sterols[16]
  •   Endosomal sorting complex required for transport escrt[28]
  •   Endosomal vacuolar pathway[10]
  •   Energy dependent regulation of mtor by lkb1 ampk[19]
  •   Enos activation and regulation[21]
  •   Er phagosome pathway[62]
  •   Erk mapk targets[22]
  •   Erks are inactivated[13]
  •   Ethanol oxidation[11]
  •   Extension of telomeres[28]
  •   Extracellular matrix organization[88]
  •   Extrinsic pathway for apoptosis[14]
  •   Facilitative na independent glucose transporters[13]
  •   Factors involved in megakaryocyte development and platelet production[133]
  •   Fanconi anemia pathway[26]
  •   Fatty acid triacylglycerol and ketone body metabolism[169]
  •   Fatty acyl coa biosynthesis[19]
  •   Fgfr ligand binding and activation[23]
  •   Fgfr1 ligand binding and activation[15]
  •   Fgfr2c ligand binding and activation[13]
  •   Fgfr4 ligand binding and activation[13]
  •   Formation of atp by chemiosmotic coupling[17]
  •   Formation of fibrin clot clotting cascade[33]
  •   Formation of incision complex in gg ner[24]
  •   Formation of rna pol ii elongation complex [46]
  •   Formation of the hiv1 early elongation complex[35]
  •   Formation of the ternary complex and subsequently the 43s complex[75]
  •   Formation of transcription coupled ner tc ner repair complex[31]
  •   Formation of tubulin folding intermediates by cct tric[23]
  •   Frs2 mediated cascade[37]
  •   G alpha i signalling events[196]
  •   G alpha q signalling events[185]
  •   G alpha s signalling events[122]
  •   G alpha z signalling events[45]
  •   G alpha1213 signalling events[75]
  •   G beta gamma signalling through pi3kgamma[26]
  •   G beta gamma signalling through plc beta[21]
  •   G protein activation[28]
  •   G protein beta gamma signalling[29]
  •   G0 and early g1[26]
  •   G1 phase[39]
  •   G1 s specific transcription[20]
  •   G1 s transition[113]
  •   G2 m checkpoints[46]
  •   G2 m dna damage checkpoint[13]
  •   Gab1 signalosome[39]
  •   Gaba a receptor activation[13]
  •   Gaba b receptor activation[39]
  •   Gaba receptor activation[53]
  •   Gaba synthesis release reuptake and degradation[18]
  •   Gamma carboxylation transport and amino terminal cleavage of proteins[12]
  •   Gap junction assembly[19]
  •   Gap junction degradation[11]
  •   Gap junction trafficking[28]
  •   Gastrin creb signalling pathway via pkc and mapk[206]
  •   Generation of second messenger molecules[28]
  •   Generic transcription pathway[353]
  •   Global genomic ner gg ner[36]
  •   Glucagon signaling in metabolic regulation[35]
  •   Glucagon type ligand receptors[34]
  •   Gluconeogenesis[35]
  •   Glucose metabolism[70]
  •   Glucose transport[39]
  •   Glucuronidation[19]
  •   Glutamate neurotransmitter release cycle[16]
  •   Glutathione conjugation[24]
  •   Glycerophospholipid biosynthesis[83]
  •   Glycogen breakdown glycogenolysis[19]
  •   Glycolysis[30]
  •   Glycoprotein hormones[13]
  •   Glycosaminoglycan metabolism[112]
  •   Glycosphingolipid metabolism[39]
  •   Golgi associated vesicle biogenesis[54]
  •   Gpcr downstream signaling[806]
  •   Gpcr ligand binding[409]
  •   Gpvi mediated activation cascade[32]
  •   Grb2 events in erbb2 signaling[23]
  •   Grb2 sos provides linkage to mapk signaling for intergrins [16]
  •   Growth hormone receptor signaling[25]
  •   Hdl mediated lipid transport[16]
  •   Hemostasis[467]
  •   Heparan sulfate heparin hs gag metabolism[53]
  •   Highly calcium permeable postsynaptic nicotinic acetylcholine receptors[14]
  •   Hiv infection[208]
  •   Hiv life cycle[126]
  •   Homologous recombination repair of replication independent double strand breaks[18]
  •   Hormone ligand binding receptors[11]
  •   Hormone sensitive lipase hsl mediated triacylglycerol hydrolysis[14]
  •   Host interactions of hiv factors[133]
  •   Hs gag biosynthesis[32]
  •   Hs gag degradation[21]
  •   Hyaluronan metabolism[15]
  •   Hyaluronan uptake and degradation[11]
  •   Ikk complex recruitment mediated by rip1[11]
  •   Il 2 signaling[42]
  •   Il 3 5 and gm csf signaling[44]
  •   Il 6 signaling[12]
  •   Il 7 signaling[12]
  •   Il receptor shc signaling[28]
  •   Il1 signaling[40]
  •   Immune system[934]
  •   Immunoregulatory interactions between a lymphoid and a non lymphoid cell[71]
  •   Incretin synthesis secretion and inactivation[23]
  •   Inflammasomes[18]
  •   Influenza life cycle[204]
  •   Influenza viral rna transcription and replication[170]
  •   Inhibition of insulin secretion by adrenaline noradrenaline[26]
  •   Inhibition of replication initiation of damaged dna by rb1 e2f1[14]
  •   Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components[25]
  •   Inhibition of voltage gated ca2 channels via gbeta gamma subunits[26]
  •   Initial triggering of complement[17]
  •   Innate immune system[280]
  •   Insulin receptor recycling[24]
  •   Insulin receptor signalling cascade[88]
  •   Insulin synthesis and processing[22]
  •   Integration of energy metabolism[121]
  •   Integration of provirus[17]
  •   Integrin alphaiib beta3 signaling[28]
  •   Integrin cell surface interactions[80]
  •   Interaction between l1 and ankyrins[24]
  •   Interactions of vpr with host cellular proteins[34]
  •   Interferon alpha beta signaling[65]
  •   Interferon gamma signaling[64]
  •   Interferon signaling[160]
  •   Intrinsic pathway[18]
  •   Intrinsic pathway for apoptosis[31]
  •   Inwardly rectifying k channels[32]
  •   Ion channel transport[56]
  •   Ion transport by p type atpases[35]
  •   Ionotropic activity of kainate receptors[12]
  •   Irak1 recruits ikk complex[11]
  •   Irak2 mediated activation of tak1 complex upon tlr7 8 or 9 stimulation[10]
  •   Iron uptake and transport[37]
  •   Jnk c jun kinases phosphorylation and activation mediated by activated human tak1[17]
  •   Keratan sulfate biosynthesis[27]
  •   Keratan sulfate degradation[12]
  •   Keratan sulfate keratin metabolism[31]
  •   Kinesins[25]
  •   L1cam interactions[87]
  •   Lagging strand synthesis[20]
  •   Late phase of hiv life cycle[105]
  •   Latent infection of homo sapiens with mycobacterium tuberculosis[34]
  •   Ligand gated ion channel transport[22]
  •   Lipid digestion mobilization and transport[47]
  •   Lipoprotein metabolism[29]
  •   Loss of nlp from mitotic centrosomes[60]
  •   Lysosome vesicle biogenesis[24]
  •   M g1 transition[82]
  •   Map kinase activation in tlr cascade[51]
  •   Mapk targets nuclear events mediated by map kinases[31]
  •   Meiosis[117]
  •   Meiotic recombination[87]
  •   Meiotic synapsis[74]
  •   Membrane binding and targetting of gag proteins[11]
  •   Membrane trafficking[130]
  •   Metabolism of amino acids and derivatives[201]
  •   Metabolism of carbohydrates[248]
  •   Metabolism of lipids and lipoproteins[479]
  •   Metabolism of mrna[285]
  •   Metabolism of non coding rna[50]
  •   Metabolism of nucleotides[73]
  •   Metabolism of polyamines[16]
  •   Metabolism of porphyrins[15]
  •   Metabolism of proteins[519]
  •   Metabolism of rna[331]
  •   Metabolism of steroid hormones and vitamins a and d[36]
  •   Metabolism of vitamins and cofactors[52]
  •   Metal ion slc transporters[23]
  •   Mhc class ii antigen presentation[92]
  •   Microrna mirna biogenesis[24]
  •   Mitochondrial fatty acid beta oxidation[15]
  •   Mitochondrial protein import[59]
  •   Mitochondrial trna aminoacylation[22]
  •   Mitotic g1 g1 s phases[138]
  •   Mitotic g2 g2 m phases[82]
  •   Mitotic m m g1 phases[173]
  •   Mitotic prometaphase[88]
  •   Mrna 3 end processing[36]
  •   Mrna capping[31]
  •   Mrna decay by 3 to 5 exoribonuclease[12]
  •   Mrna decay by 5 to 3 exoribonuclease[16]
  •   Mrna processing[162]
  •   Mrna splicing[112]
  •   Mrna splicing minor pathway[46]
  •   Mtorc1 mediated signalling[12]
  •   Muscle contraction[49]
  •   Myd88 mal cascade initiated on plasma membrane[84]
  •   Myogenesis[29]
  •   N glycan antennae elongation[15]
  •   N glycan antennae elongation in the medial trans golgi[19]
  •   N glycan trimming in the er and calnexin calreticulin cycle[14]
  •   Na cl dependent neurotransmitter transporters[18]
  •   Ncam signaling for neurite out growth[65]
  •   Ncam1 interactions[40]
  •   Nef mediated downregulation of mhc class i complex cell surface expression[11]
  •   Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters[22]
  •   Negative regulation of fgfr signaling[38]
  •   Negative regulation of the pi3k akt network[10]
  •   Negative regulators of rig i mda5 signaling[32]
  •   Nep ns2 interacts with the cellular export machinery[28]
  •   Nephrin interactions[21]
  •   Netrin1 signaling[42]
  •   Neuronal system[280]
  •   Neurotransmitter receptor binding and downstream transmission in the postsynaptic cell[138]
  •   Neurotransmitter release cycle[35]
  •   Nfkb activation through fadd rip1 pathway mediated by caspase 8 and10[13]
  •   Nfkb and map kinases activation mediated by tlr4 signaling repertoire[73]
  •   Nfkb is activated and signals survival[12]
  •   Ngf signalling via trka from the plasma membrane[138]
  •   Nitric oxide stimulates guanylate cyclase[26]
  •   Nod1 2 signaling pathway[31]
  •   Nonsense mediated decay enhanced by the exon junction complex[177]
  •   Norepinephrine neurotransmitter release cycle[11]
  •   Notch hlh transcription pathway[14]
  •   Notch1 intracellular domain regulates transcription[47]
  •   Nrage signals death through jnk[44]
  •   Nrif signals cell death from the nucleus[16]
  •   Nuclear events kinase and transcription factor activation[25]
  •   Nuclear receptor transcription pathway[50]
  •   Nuclear signaling by erbb4[39]
  •   Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways[47]
  •   Nucleotide excision repair[52]
  •   Nucleotide like purinergic receptors[17]
  •   O linked glycosylation of mucins[60]
  •   Olfactory signaling pathway[329]
  •   Opioid signalling[79]
  •   Opsins[11]
  •   Orc1 removal from chromatin[68]
  •   Organic cation anion zwitterion transport[14]
  •   Other semaphorin interactions[16]
  •   Oxygen dependent proline hydroxylation of hypoxia inducible factor alpha[19]
  •   P130cas linkage to mapk signaling for integrins[16]
  •   P2y receptors[13]
  •   P38mapk events[14]
  •   P53 dependent g1 dna damage response[58]
  •   P53 independent g1 s dna damage checkpoint[52]
  •   P75 ntr receptor mediated signalling[82]
  •   P75ntr recruits signalling complexes[13]
  •   P75ntr signals via nfkb[15]
  •   Packaging of telomere ends[49]
  •   Passive transport by aquaporins[12]
  •   Pd1 signaling[19]
  •   Pecam1 interactions[11]
  •   Peptide chain elongation[154]
  •   Peptide hormone biosynthesis[15]
  •   Peptide ligand binding receptors[189]
  •   Perk regulated gene expression[30]
  •   Peroxisomal lipid metabolism[22]
  •   Phase ii conjugation[71]
  •   Phase1 functionalization of compounds[71]
  •   Phospholipase c mediated cascade[55]
  •   Phospholipid metabolism[199]
  •   Phosphorylation of cd3 and tcr zeta chains[17]
  •   Phosphorylation of the apc c[24]
  •   Pi 3k cascade[57]
  •   Pi metabolism[49]
  •   Pi3k akt activation[39]
  •   Pi3k cascade[72]
  •   Pi3k events in erbb2 signaling[45]
  •   Pi3k events in erbb4 signaling[39]
  •   Pip3 activates akt signaling[30]
  •   Pka mediated phosphorylation of creb[19]
  •   Pkb mediated events[30]
  •   Platelet activation signaling and aggregation[209]
  •   Platelet adhesion to exposed collagen[13]
  •   Platelet aggregation plug formation[37]
  •   Platelet calcium homeostasis[19]
  •   Platelet homeostasis[79]
  •   Platelet sensitization by ldl[17]
  •   Plc beta mediated events[44]
  •   Pol switching[14]
  •   Post chaperonin tubulin folding pathway[20]
  •   Post nmda receptor activation events[34]
  •   Post translational modification synthesis of gpi anchored proteins[27]
  •   Post translational protein modification[189]
  •   Potassium channels[99]
  •   Ppara activates gene expression[105]
  •   Pre notch expression and processing[45]
  •   Pre notch processing in golgi[17]
  •   Pre notch transcription and translation[30]
  •   Prefoldin mediated transfer of substrate to cct tric[29]
  •   Presynaptic nicotinic acetylcholine receptors[13]
  •   Processing of capped intron containing pre mrna[141]
  •   Processing of capped intronless pre mrna[24]
  •   Processing of intronless pre mrnas[15]
  •   Processive synthesis on the lagging strand[16]
  •   Prolactin receptor signaling[15]
  •   Prolonged erk activation events[20]
  •   Prostacyclin signalling through prostacyclin receptor[20]
  •   Prostanoid ligand receptors[11]
  •   Protein folding[54]
  •   Proteolytic cleavage of snare complex proteins[18]
  •   Ptm gamma carboxylation hypusine formation and arylsulfatase activation[28]
  •   Purine catabolism[11]
  •   Purine metabolism[34]
  •   Purine ribonucleoside monophosphate biosynthesis[12]
  •   Purine salvage[14]
  •   Pyrimidine catabolism[13]
  •   Pyrimidine metabolism[25]
  •   Pyruvate metabolism[20]
  •   Pyruvate metabolism and citric acid tca cycle[49]
  •   Raf map kinase cascade[11]
  •   Rap1 signalling[18]
  •   Ras activation uopn ca2 infux through nmda receptor[18]
  •   Receptor ligand binding initiates the second proteolytic cleavage of notch receptor[13]
  •   Recruitment of mitotic centrosome proteins and complexes[67]
  •   Recruitment of numa to mitotic centrosomes[11]
  •   Recycling of bile acids and salts[12]
  •   Recycling pathway of l1[28]
  •   Regulated proteolysis of p75ntr[11]
  •   Regulation of ampk activity via lkb1[16]
  •   Regulation of apoptosis[59]
  •   Regulation of beta cell development[31]
  •   Regulation of complement cascade[15]
  •   Regulation of gene expression in beta cells[21]
  •   Regulation of glucokinase by glucokinase regulatory protein[28]
  •   Regulation of hypoxia inducible factor hif by oxygen[26]
  •   Regulation of ifna signaling[25]
  •   Regulation of ifng signaling[15]
  •   Regulation of insulin like growth factor igf activity by insulin like growth factor binding proteins igfbps[17]
  •   Regulation of insulin secretion[94]
  •   Regulation of insulin secretion by acetylcholine[12]
  •   Regulation of insulin secretion by glucagon like peptide1[44]
  •   Regulation of kit signaling[18]
  •   Regulation of mitotic cell cycle[86]
  •   Regulation of mrna stability by proteins that bind au rich elements[85]
  •   Regulation of ornithine decarboxylase odc[50]
  •   Regulation of pyruvate dehydrogenase pdh complex[14]
  •   Regulation of rheb gtpase activity by ampk[11]
  •   Regulation of signaling by cbl[19]
  •   Regulation of the fanconi anemia pathway[12]
  •   Regulation of water balance by renal aquaporins[45]
  •   Regulatory rna pathways[27]
  •   Removal of the flap intermediate from the c strand[11]
  •   Repair synthesis for gap filling by dna pol in tc ner[15]
  •   Resolution of ap sites via the multiple nucleotide patch replacement pathway[18]
  •   Resolution of ap sites via the single nucleotide replacement pathway[13]
  •   Respiratory electron transport[80]
  •   Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins [99]
  •   Response to elevated platelet cytosolic ca2 [90]
  •   Retrograde neurotrophin signalling[14]
  •   Reversible hydration of carbon dioxide[13]
  •   Rig i mda5 mediated induction of ifn alpha beta pathways[74]
  •   Rip mediated nfkb activation via dai[19]
  •   Rna pol i promoter opening[63]
  •   Rna pol i rna pol iii and mitochondrial transcription[123]
  •   Rna pol i transcription[90]
  •   Rna pol i transcription initiation[26]
  •   Rna pol i transcription termination[23]
  •   Rna pol ii pre transcription events[62]
  •   Rna pol ii transcription[106]
  •   Rna pol ii transcription pre initiation and promoter opening[42]
  •   Rna pol iii chain elongation[18]
  •   Rna pol iii transcription[34]
  •   Rna pol iii transcription initiation from type 2 promoter[24]
  •   Rna pol iii transcription initiation from type 3 promoter[27]
  •   Rna pol iii transcription termination[20]
  •   Role of dcc in regulating apoptosis[11]
  •   Role of second messengers in netrin1 signaling[12]
  •   Rora activates circadian expression[25]
  •   S phase[110]
  •   Scf beta trcp mediated degradation of emi1[52]
  •   Scfskp2 mediated degradation of p27 p21[57]
  •   Sema3a pak dependent axon repulsion[16]
  •   Sema3a plexin repulsion signaling by inhibiting integrin adhesion[14]
  •   Sema4d in semaphorin signaling[33]
  •   Sema4d induced cell migration and growth cone collapse[28]
  •   Semaphorin interactions[69]
  •   Serotonin receptors[13]
  •   Shc mediated cascade[29]
  •   Shc mediated signalling[16]
  •   Shc related events[18]
  •   Shc1 events in egfr signaling[16]
  •   Shc1 events in erbb4 signaling[21]
  •   Signal amplification[32]
  •   Signal attenuation[15]
  •   Signal regulatory protein sirp family interactions[13]
  •   Signal transduction by l1[35]
  •   Signaling by activated point mutants of fgfr1[12]
  •   Signaling by bmp[24]
  •   Signaling by constitutively active egfr[19]
  •   Signaling by egfr in cancer[110]
  •   Signaling by erbb2[102]
  •   Signaling by erbb4[91]
  •   Signaling by fgfr[113]
  •   Signaling by fgfr in disease[128]
  •   Signaling by fgfr mutants[45]
  •   Signaling by fgfr1 fusion mutants[20]
  •   Signaling by fgfr1 mutants[31]
  •   Signaling by fgfr3 mutants[12]
  •   Signaling by gpcr[921]
  •   Signaling by hippo[23]
  •   Signaling by ils[108]
  •   Signaling by insulin receptor[109]
  •   Signaling by nodal[19]
  •   Signaling by notch[104]
  •   Signaling by notch1[71]
  •   Signaling by notch2[13]
  •   Signaling by notch3[13]
  •   Signaling by notch4[13]
  •   Signaling by pdgf[123]
  •   Signaling by rho gtpases[114]
  •   Signaling by robo receptor[31]
  •   Signaling by scf kit[79]
  •   Signaling by tgf beta receptor complex[64]
  •   Signaling by the b cell receptor bcr[127]
  •   Signaling by wnt[66]
  •   Signalling by ngf[218]
  •   Signalling to erks[37]
  •   Signalling to p38 via rit and rin[16]
  •   Signalling to ras[28]
  •   Slbp dependent processing of replication dependent histone pre mrnas[12]
  •   Slc mediated transmembrane transport[242]
  •   Smad2 smad3 smad4 heterotrimer regulates transcription[28]
  •   Smooth muscle contraction[26]
  •   Sos mediated signalling[15]
  •   Sphingolipid de novo biosynthesis[32]
  •   Sphingolipid metabolism[70]
  •   Spry regulation of fgf signaling[15]
  •   Srp dependent cotranslational protein targeting to membrane[180]
  •   Steroid hormones[30]
  •   Striated muscle contraction[28]
  •   Sulfur amino acid metabolism[25]
  •   Synthesis and interconversion of nucleotide di and triphosphates[20]
  •   Synthesis of bile acids and bile salts[20]
  •   Synthesis of bile acids and bile salts via 24 hydroxycholesterol[11]
  •   Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol[16]
  •   Synthesis of dna[93]
  •   Synthesis of glycosylphosphatidylinositol gpi[18]
  •   Synthesis of pa[28]
  •   Synthesis of pc[19]
  •   Synthesis of pe[12]
  •   Synthesis of pips at the early endosome membrane[13]
  •   Synthesis of pips at the golgi membrane[18]
  •   Synthesis of pips at the late endosome membrane[11]
  •   Synthesis of pips at the plasma membrane[32]
  •   Synthesis of substrates in n glycan biosythesis[15]
  •   Synthesis of very long chain fatty acyl coas[15]
  •   Synthesis secretion and deacylation of ghrelin[17]
  •   Synthesis secretion and inactivation of gip[15]
  •   Synthesis secretion and inactivation of glp1[20]
  •   Tak1 activates nfkb by phosphorylation and activation of ikks complex[24]
  •   Tandem pore domain potassium channels[13]
  •   Tca cycle and respiratory electron transport[142]
  •   Tcr signaling[55]
  •   Telomere maintenance[76]
  •   Termination of o glycan biosynthesis[25]
  •   Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation[14]
  •   Tgf beta receptor signaling activates smads[27]
  •   Tgf beta receptor signaling in emt epithelial to mesenchymal transition[17]
  •   The activation of arylsulfatases[13]
  •   The nlrp3 inflammasome[13]
  •   The role of nef in hiv1 replication and disease pathogenesis[29]
  •   Thrombin signalling through proteinase activated receptors pars[33]
  •   Thromboxane signalling through tp receptor[24]
  •   Tie2 signaling[18]
  •   Tight junction interactions[30]
  •   Toll receptor cascades[119]
  •   Traf3 dependent irf activation pathway[15]
  •   Traf6 mediated induction of nfkb and map kinases upon tlr7 8 or 9 activation[78]
  •   Traf6 mediated induction of tak1 complex[15]
  •   Traf6 mediated irf7 activation[31]
  •   Traf6 mediated irf7 activation in tlr7 8 or 9 signaling[11]
  •   Traf6 mediated nfkb activation[22]
  •   Trafficking and processing of endosomal tlr[15]
  •   Trafficking of ampa receptors[29]
  •   Trafficking of glur2 containing ampa receptors[17]
  •   Trans golgi network vesicle budding[61]
  •   Transcription[211]
  •   Transcription coupled ner tc ner[46]
  •   Transcriptional activity of smad2 smad3 smad4 heterotrimer[39]
  •   Transcriptional regulation of white adipocyte differentiation[73]
  •   Transferrin endocytosis and recycling[26]
  •   Translation[223]
  •   Translocation of zap 70 to immunological synapse[15]
  •   Transmembrane transport of small molecules[414]
  •   Transmission across chemical synapses[187]
  •   Transport of glucose and other sugars bile salts and organic acids metal ions and amine compounds[90]
  •   Transport of inorganic cations anions and amino acids oligopeptides[95]
  •   Transport of mature mrna derived from an intronless transcript[34]
  •   Transport of mature transcript to cytoplasm[55]
  •   Transport of organic anions[12]
  •   Transport of ribonucleoproteins into the host nucleus[28]
  •   Transport of vitamins nucleosides and related molecules[32]
  •   Transport to the golgi and subsequent modification[34]
  •   Trif mediated tlr3 signaling[75]
  •   Triglyceride biosynthesis[39]
  •   Trna aminoacylation[43]
  •   Tryptophan catabolism[12]
  •   Unblocking of nmda receptor glutamate binding and activation[16]
  •   Unfolded protein response[81]
  •   Unwinding of dna[12]
  •   Vegf ligand receptor interactions[11]
  •   Vif mediated degradation of apobec3g[53]
  •   Viral messenger rna synthesis[15]
  •   Vitamin b5 pantothenate metabolism[12]
  •   Voltage gated potassium channels[44]
  •   Xenobiotics[17]
  •   Yap1 and wwtr1 taz stimulated gene expression[25]
  •   Zinc transporters[16]
Sample Grouping
A Normal Adrenal Cortex
1 GSM277090 Normal Adrenal Cortex 006age: 71Sex: Fside of body: Leftcinical characteristics: Adrenalectomy for metastatic lung carcinomatumor diameter (cm): not applicabletumor weight (gm): not applicableweiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
2 GSM277091 Normal Adrenal Cortex 063age: 58Sex: Fside of body: Rightcinical characteristics: Adrenalectomy for ACA; Conns syndrometumor diameter (cm): not applicabletumor weight (gm): not applicableweiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
3 GSM277092 Normal Adrenal Cortex 069age: 71Sex: Mside of body: Rightcinical characteristics: Adrenalectomy for renal cell carcinomatumor diameter (cm): not applicabletumor weight (gm): not applicableweiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
4 GSM277093 Normal Adrenal Cortex 076age: 44Sex: Mside of body: Leftcinical characteristics: Adrenalectomy for ACA; Conns syndrometumor diameter (cm): not applicabletumor weight (gm): not applicableweiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
5 GSM277094 Normal Adrenal Cortex 083age: 32Sex: Fside of body: Rightcinical characteristics: Adrenalectomy for ACAtumor diameter (cm): not applicabletumor weight (gm): not applicableweiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
6 GSM277095 Normal Adrenal Cortex 085age: 28Sex: Mside of body: Leftcinical characteristics: Adrenalectomy for pheochromocytoma (Multiple Endocrine Neoplasia, Type IIA)tumor diameter (cm): not applicabletumor weight (gm): not applicableweiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
7 GSM277096 Normal Adrenal Cortex 087age: 55Sex: Mside of body: Leftcinical characteristics: Adrenalectomy for multinodular cortical hyperplasia; Conns syndrometumor diameter (cm): not applicabletumor weight (gm): not applicableweiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
8 GSM277097 Normal Adrenal Cortex 088age: 78Sex: Mside of body: Leftcinical characteristics: Adrenalectomy for renal cell carcinomatumor diameter (cm): not applicabletumor weight (gm): not applicableweiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
9 GSM277098 Normal Adrenal Cortex 092age: 41Sex: Mside of body: unknowncinical characteristics: Adrenalectomy for renal cell carcinomatumor diameter (cm): not applicabletumor weight (gm): not applicableweiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
10 GSM277099 Normal Adrenal Cortex 097age: 58Sex: Mside of body: Leftcinical characteristics: Adrenalectomy for pheochromocytomatumor diameter (cm): not applicabletumor weight (gm): not applicableweiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
B Adrenocortical Adenoma
1 GSM277100 Adrenocortical Adenoma 021age: 62Sex: Fside of body: Rightcinical characteristics: Hypertensiontumor diameter (cm): 3.3tumor weight (gm): 65weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
2 GSM277101 Adrenocortical Adenoma 022age: 45Sex: Fside of body: Leftcinical characteristics: Cushing Syndrometumor diameter (cm): 2.5tumor weight (gm): 12.1weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
3 GSM277102 Adrenocortical Adenoma 028age: 28Sex: Fside of body: Leftcinical characteristics: Cushing Syndrometumor diameter (cm): 3.5tumor weight (gm): 25.2weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
4 GSM277103 Adrenocortical Adenoma 030age: 25Sex: Fside of body: Rightcinical characteristics: Cushing Syndrometumor diameter (cm): 2.5tumor weight (gm): 16weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
5 GSM277104 Adrenocortical Adenoma 040age: 25Sex: Fside of body: Leftcinical characteristics: Cushing Syndrometumor diameter (cm): 2.7tumor weight (gm): 11.1weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
6 GSM277105 Adrenocortical Adenoma 059age: 56Sex: Fside of body: Rightcinical characteristics: Hyperaldosteronismtumor diameter (cm): 2.2tumor weight (gm): 8.2weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
7 GSM277106 Adrenocortical Adenoma 064age: 33Sex: Fside of body: Leftcinical characteristics: Hyperaldosteronismtumor diameter (cm): 1.1tumor weight (gm): 17.2weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
8 GSM277107 Adrenocortical Adenoma 065age: 52Sex: Mside of body: Leftcinical characteristics: Left adrenal masstumor diameter (cm): 6.2tumor weight (gm): 57weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
9 GSM277108 Adrenocortical Adenoma 068age: 44Sex: Mside of body: Leftcinical characteristics: Aldosteronomatumor diameter (cm): unknowntumor weight (gm): 10.5weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
10 GSM277109 Adrenocortical Adenoma 070age: 54Sex: Fside of body: Rightcinical characteristics: Right pheochromocytomatumor diameter (cm): 3.5tumor weight (gm): 12.5weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
11 GSM277110 Adrenocortical Adenoma 071age: 71Sex: Fside of body: Leftcinical characteristics: Conns syndrometumor diameter (cm): 1.3tumor weight (gm): 8.5weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
12 GSM277111 Adrenocortical Adenoma 072age: 56Sex: Fside of body: Leftcinical characteristics: Left adrenal masstumor diameter (cm): 1.5tumor weight (gm): 7.6weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
13 GSM277112 Adrenocortical Adenoma 075age: 48Sex: Mside of body: Leftcinical characteristics: Abdominal paintumor diameter (cm): 9tumor weight (gm): 174.5weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
14 GSM277113 Adrenocortical Adenoma 077age: 55Sex: Mside of body: Leftcinical characteristics: Cushing Syndrometumor diameter (cm): 4.5tumor weight (gm): 31weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
15 GSM277114 Adrenocortical Adenoma 078age: 51Sex: Fside of body: Rightcinical characteristics: Aldosteronomatumor diameter (cm): 2.5tumor weight (gm): 4.95weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
16 GSM277115 Adrenocortical Adenoma 079age: 32Sex: Fside of body: Rightcinical characteristics: Hyperaldosteronismtumor diameter (cm): 5tumor weight (gm): 14.9weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
17 GSM277116 Adrenocortical Adenoma 080age: 38Sex: Mside of body: Leftcinical characteristics: Hyperaldosteronismtumor diameter (cm): 2.5tumor weight (gm): 23.6weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
18 GSM277117 Adrenocortical Adenoma 081age: 64Sex: Fside of body: Rightcinical characteristics: Right adrenal masstumor diameter (cm): 7.2tumor weight (gm): 116weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
19 GSM277118 Adrenocortical Adenoma 082age: 49Sex: Fside of body: Leftcinical characteristics: Bilateral adrenal massestumor diameter (cm): 4.2tumor weight (gm): 22.4weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
20 GSM277119 Adrenocortical Adenoma 095age: 59Sex: Mside of body: Rightcinical characteristics: Right adrenal masstumor diameter (cm): 7tumor weight (gm): 95weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
21 GSM277120 Adrenocortical Adenoma 099age: 45Sex: Mside of body: Leftcinical characteristics: Left adrenal masstumor diameter (cm): 5.5tumor weight (gm): 45weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
22 GSM277121 Adrenocortical Adenoma 029age: 57Sex: Fside of body: Rightcinical characteristics: Cushing Syndrometumor diameter (cm): 5.5tumor weight (gm): 50weiss grade of tumor: not applicablemitotic rate of tumor: not applicabletumor stage: not applicableadrenocortical carcinoma cluster in our analysis: not applicableyears to last followup: not applicabledead or alive at last followup: not applicablefirst principal component for 33 accs: not applicable
C Adrenocortical Carcinoma
1 GSM277122 Adrenocortical Carcinoma 001age: 41Sex: Fside of body: Leftcinical characteristics: Left adrenal masstumor diameter (cm): 17tumor weight (gm): 2540weiss grade of tumor: Lowmitotic rate of tumor: 12tumor stage: 3adrenocortical carcinoma cluster in our analysis: 2years to last followup: 4.753dead or alive at last followup: deadfirst principal component for 33 accs: -7.5326617
2 GSM277123 Adrenocortical Carcinoma 008age: 45Sex: Fside of body: Leftcinical characteristics: Left adrenal masstumor diameter (cm): 9tumor weight (gm): 180weiss grade of tumor: Highmitotic rate of tumor: 24tumor stage: 2adrenocortical carcinoma cluster in our analysis: 1years to last followup: 1.512dead or alive at last followup: deadfirst principal component for 33 accs: 9.3626403
3 GSM277124 Adrenocortical Carcinoma 011age: 48Sex: Fside of body: not applicablecinical characteristics: History of Adrenocortical carcinomatumor diameter (cm): unknowntumor weight (gm): unknownweiss grade of tumor: Highmitotic rate of tumor: 51tumor stage: 4adrenocortical carcinoma cluster in our analysis: 2years to last followup: 1.658dead or alive at last followup: deadfirst principal component for 33 accs: -21.661757
4 GSM277125 Adrenocortical Carcinoma 013age: 35Sex: Fside of body: Leftcinical characteristics: History of Adrenocortical carcinoma with lung, liver and bone metastises 1 year priortumor diameter (cm): 16tumor weight (gm): 460weiss grade of tumor: Lowmitotic rate of tumor: 8tumor stage: 4adrenocortical carcinoma cluster in our analysis: 2years to last followup: 1.233dead or alive at last followup: deadfirst principal component for 33 accs: -14.953185
5 GSM277126 Adrenocortical Carcinoma 014age: 71Sex: Mside of body: Rightcinical characteristics: Right adrenal tumor; Leg edematumor diameter (cm): 22tumor weight (gm): 2440weiss grade of tumor: Highmitotic rate of tumor: 22tumor stage: 4adrenocortical carcinoma cluster in our analysis: 1years to last followup: 0.625dead or alive at last followup: deadfirst principal component for 33 accs: 26.18381
6 GSM277127 Adrenocortical Carcinoma 016age: <10Sex: Fside of body: Rightcinical characteristics: Virilization and microcephalytumor diameter (cm): 3.2tumor weight (gm): 12weiss grade of tumor: Highmitotic rate of tumor: 22tumor stage: 1adrenocortical carcinoma cluster in our analysis: 1years to last followup: 12.468dead or alive at last followup: alivefirst principal component for 33 accs: 4.8672796
7 GSM277128 Adrenocortical Carcinoma 017age: 25Sex: Fside of body: Rightcinical characteristics: History of adrenal mass; 2 month history of abdominal paintumor diameter (cm): 26tumor weight (gm): 2300weiss grade of tumor: Highmitotic rate of tumor: 34tumor stage: 4adrenocortical carcinoma cluster in our analysis: 1years to last followup: 0.899dead or alive at last followup: deadfirst principal component for 33 accs: 15.450931
8 GSM277129 Adrenocortical Carcinoma 018age: 39Sex: Fside of body: Leftcinical characteristics: Cushing Syndrometumor diameter (cm): 18tumor weight (gm): 900weiss grade of tumor: Highmitotic rate of tumor: 109tumor stage: 3adrenocortical carcinoma cluster in our analysis: 1years to last followup: 0.09dead or alive at last followup: deadfirst principal component for 33 accs: 13.572902
9 GSM277130 Adrenocortical Carcinoma 019age: 45Sex: Fside of body: Rightcinical characteristics: Right flank pain; Masses in right kidney, liver and both lungstumor diameter (cm): 9tumor weight (gm): unknownweiss grade of tumor: Highmitotic rate of tumor: 137tumor stage: 4adrenocortical carcinoma cluster in our analysis: 1years to last followup: 0.121dead or alive at last followup: deadfirst principal component for 33 accs: 7.5158534
10 GSM277131 Adrenocortical Carcinoma 032age: 55Sex: Mside of body: Leftcinical characteristics: Cushing Syndrome; Left adrenalectomy 3 years prior for adrenocortical tumortumor diameter (cm): 5.5tumor weight (gm): 35.1weiss grade of tumor: Lowmitotic rate of tumor: 4tumor stage: 2adrenocortical carcinoma cluster in our analysis: 2years to last followup: unknowndead or alive at last followup: unknownfirst principal component for 33 accs: -7.6729512
11 GSM277132 Adrenocortical Carcinoma 033age: <10Sex: Mside of body: Leftcinical characteristics: Increased testosteronetumor diameter (cm): 12tumor weight (gm): 450weiss grade of tumor: Highmitotic rate of tumor: 64tumor stage: 4adrenocortical carcinoma cluster in our analysis: 1years to last followup: 0.477dead or alive at last followup: deadfirst principal component for 33 accs: 14.572298
12 GSM277133 Adrenocortical Carcinoma 034age: 52Sex: Fside of body: Rightcinical characteristics: Right adrenal masstumor diameter (cm): 19tumor weight (gm): 2890weiss grade of tumor: Lowmitotic rate of tumor: 2tumor stage: 2adrenocortical carcinoma cluster in our analysis: 2years to last followup: 2.781dead or alive at last followup: deadfirst principal component for 33 accs: -23.314927
13 GSM277134 Adrenocortical Carcinoma 035age: 45Sex: Mside of body: Leftcinical characteristics: unknowntumor diameter (cm): 5tumor weight (gm): 60weiss grade of tumor: Lowmitotic rate of tumor: 2tumor stage: 2adrenocortical carcinoma cluster in our analysis: 2years to last followup: 5.342dead or alive at last followup: alivefirst principal component for 33 accs: -29.0056
14 GSM277135 Adrenocortical Carcinoma 038age: 47Sex: Fside of body: Rightcinical characteristics: Cushing Syndrome; Right adrenalectomy 4 years priortumor diameter (cm): unknowntumor weight (gm): unknownweiss grade of tumor: Highmitotic rate of tumor: 37tumor stage: 1adrenocortical carcinoma cluster in our analysis: 2years to last followup: 4.334dead or alive at last followup: alivefirst principal component for 33 accs: -3.1454015
15 GSM277136 Adrenocortical Carcinoma 039age: 60Sex: Fside of body: Rightcinical characteristics: Cushing Syndrometumor diameter (cm): 18.5tumor weight (gm): 1805weiss grade of tumor: Highmitotic rate of tumor: 40tumor stage: 2adrenocortical carcinoma cluster in our analysis: 1years to last followup: 0.364dead or alive at last followup: deadfirst principal component for 33 accs: 4.6373137
16 GSM277137 Adrenocortical Carcinoma 042age: 61Sex: Fside of body: Rightcinical characteristics: Cushing Syndrometumor diameter (cm): 9.8tumor weight (gm): 253weiss grade of tumor: Highmitotic rate of tumor: 27tumor stage: 2adrenocortical carcinoma cluster in our analysis: 1years to last followup: 0.942dead or alive at last followup: deadfirst principal component for 33 accs: 17.714257
17 GSM277138 Adrenocortical Carcinoma 046age: 55Sex: Fside of body: Leftcinical characteristics: Hyperaldosteronismtumor diameter (cm): 10tumor weight (gm): 212weiss grade of tumor: Lowmitotic rate of tumor: 15tumor stage: 2adrenocortical carcinoma cluster in our analysis: 1years to last followup: unknowndead or alive at last followup: unknownfirst principal component for 33 accs: 13.073042
18 GSM277139 Adrenocortical Carcinoma 047age: 49Sex: Fside of body: Leftcinical characteristics: Elevated serum aldosterone and DHEA-S; History of left nephrectomytumor diameter (cm): 8.7tumor weight (gm): 397weiss grade of tumor: Highmitotic rate of tumor: 28tumor stage: 2adrenocortical carcinoma cluster in our analysis: 1years to last followup: 1.732dead or alive at last followup: deadfirst principal component for 33 accs: 1.8408304
19 GSM277140 Adrenocortical Carcinoma 048age: 31Sex: Fside of body: Rightcinical characteristics: Liver tumor; Severe abdominal paintumor diameter (cm): 12tumor weight (gm): 520weiss grade of tumor: Highmitotic rate of tumor: 65tumor stage: 2adrenocortical carcinoma cluster in our analysis: 1years to last followup: 8.868dead or alive at last followup: alivefirst principal component for 33 accs: 4.6025965
20 GSM277141 Adrenocortical Carcinoma 051age: 51Sex: Fside of body: Rightcinical characteristics: Right adrenal mass; elevated androgens and cortisoltumor diameter (cm): 15.5tumor weight (gm): 1305weiss grade of tumor: Highmitotic rate of tumor: 23tumor stage: 3adrenocortical carcinoma cluster in our analysis: 2years to last followup: 2.233dead or alive at last followup: deadfirst principal component for 33 accs: -3.4816926
21 GSM277142 Adrenocortical Carcinoma 053age: 52Sex: Mside of body: Leftcinical characteristics: Left adrenal masstumor diameter (cm): 19tumor weight (gm): 2310weiss grade of tumor: Lowmitotic rate of tumor: 1tumor stage: 2adrenocortical carcinoma cluster in our analysis: 2years to last followup: unknowndead or alive at last followup: unknownfirst principal component for 33 accs: -14.304984
22 GSM277143 Adrenocortical Carcinoma 054age: 87Sex: Fside of body: Leftcinical characteristics: unknowntumor diameter (cm): 16.5tumor weight (gm): 1690.4weiss grade of tumor: Lowmitotic rate of tumor: 0tumor stage: 2adrenocortical carcinoma cluster in our analysis: 2years to last followup: unknowndead or alive at last followup: unknownfirst principal component for 33 accs: -31.599823
23 GSM277144 Adrenocortical Carcinoma 055age: 31Sex: Fside of body: not applicablecinical characteristics: History of Adrenocortical carcinomatumor diameter (cm): unknowntumor weight (gm): unknownweiss grade of tumor: Lowmitotic rate of tumor: 16tumor stage: 4adrenocortical carcinoma cluster in our analysis: 1years to last followup: unknowndead or alive at last followup: unknownfirst principal component for 33 accs: 20.294326
24 GSM277145 Adrenocortical Carcinoma 056age: 32Sex: Fside of body: Rightcinical characteristics: Hyperaldosteronismtumor diameter (cm): 8.5tumor weight (gm): 400weiss grade of tumor: Lowmitotic rate of tumor: 7tumor stage: 2adrenocortical carcinoma cluster in our analysis: 2years to last followup: unknowndead or alive at last followup: unknownfirst principal component for 33 accs: -0.72911577
25 GSM277146 Adrenocortical Carcinoma 057age: 33Sex: Fside of body: Leftcinical characteristics: Cortisol secreting tumortumor diameter (cm): 13tumor weight (gm): 660weiss grade of tumor: Highmitotic rate of tumor: 70tumor stage: 3adrenocortical carcinoma cluster in our analysis: 2years to last followup: unknowndead or alive at last followup: unknownfirst principal component for 33 accs: -5.7767029
26 GSM277147 Adrenocortical Carcinoma 058age: 40Sex: Fside of body: Leftcinical characteristics: Left adrenal masstumor diameter (cm): 15.5tumor weight (gm): unknownweiss grade of tumor: Lowmitotic rate of tumor: 9tumor stage: 3adrenocortical carcinoma cluster in our analysis: 2years to last followup: unknowndead or alive at last followup: unknownfirst principal component for 33 accs: -15.611502
27 GSM277148 Adrenocortical Carcinoma 084age: 77Sex: Mside of body: not applicablecinical characteristics: Tumor of left hepatic lobetumor diameter (cm): unknowntumor weight (gm): unknownweiss grade of tumor: Highmitotic rate of tumor: 45tumor stage: 4adrenocortical carcinoma cluster in our analysis: 2years to last followup: 1.203dead or alive at last followup: deadfirst principal component for 33 accs: 2.5945033
28 GSM277149 Adrenocortical Carcinoma 089age: 34Sex: Mside of body: Leftcinical characteristics: unknowntumor diameter (cm): 9.2tumor weight (gm): 266weiss grade of tumor: Highmitotic rate of tumor: 74tumor stage: 2adrenocortical carcinoma cluster in our analysis: 1years to last followup: 0.775dead or alive at last followup: deadfirst principal component for 33 accs: 10.639152
29 GSM277150 Adrenocortical Carcinoma 094age: 50Sex: Mside of body: Leftcinical characteristics: Left adrenal masstumor diameter (cm): 15tumor weight (gm): 360weiss grade of tumor: Highmitotic rate of tumor: 45tumor stage: 2adrenocortical carcinoma cluster in our analysis: 1years to last followup: unknowndead or alive at last followup: unknownfirst principal component for 33 accs: 24.645546
30 GSM277151 Adrenocortical Carcinoma 098age: 49Sex: Fside of body: not applicablecinical characteristics: Status post adrenalectomytumor diameter (cm): unknowntumor weight (gm): unknownweiss grade of tumor: Lowmitotic rate of tumor: 6tumor stage: 4adrenocortical carcinoma cluster in our analysis: 2years to last followup: 2.721dead or alive at last followup: alivefirst principal component for 33 accs: -6.862668
31 GSM277152 Adrenocortical Carcinoma 101age: 48Sex: Mside of body: Leftcinical characteristics: Left adrenal masstumor diameter (cm): 6.2tumor weight (gm): 110weiss grade of tumor: Lowmitotic rate of tumor: 4tumor stage: 2adrenocortical carcinoma cluster in our analysis: 2years to last followup: 2.068dead or alive at last followup: alivefirst principal component for 33 accs: -20.204504
32 GSM277153 Adrenocortical Carcinoma 102age: 19Sex: Mside of body: Leftcinical characteristics: Left adrenal masstumor diameter (cm): 10.5tumor weight (gm): unknownweiss grade of tumor: Highmitotic rate of tumor: 27tumor stage: 2adrenocortical carcinoma cluster in our analysis: 1years to last followup: 0.619dead or alive at last followup: deadfirst principal component for 33 accs: 21.41453
33 GSM277154 Adrenocortical Carcinoma 103age: 47Sex: Fside of body: Leftcinical characteristics: Left adrenal masstumor diameter (cm): 16tumor weight (gm): unknownweiss grade of tumor: Highmitotic rate of tumor: 41tumor stage: 2adrenocortical carcinoma cluster in our analysis: 2years to last followup: 2.011dead or alive at last followup: alivefirst principal component for 33 accs: -7.124336
Gene Information
Official Symbol
PIK3CA
Officical Full Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Primary Source
HGNC:8975
See related
MIM:171834 HPRD:01382
Chromosome Location
3q26.3
Gene Type
protein-coding
Also known as
CLOVE CWS5 MCAP MCM MCMTC PI3K p110-alpha
External Sources
GUDMAP
Experiment Description
Accession
RGED10927
Type
Microarray
Summary
Human samples of 33 adrenocortical carcinomas, 22 adrenocortical adenomas, and 10 normal adrenal cortex samples, each from a different patient, had mRNA assays performed using Affymetrix HG_U133_plus_2 arrays, with 54675 probe-sets. We note that the same array data is in GEO series GSE33371, where we assayed the cancer samples for Beta-catenin staining or mutation, and make new comparisons based on those assays. Keywords: disease state analysis
Experiment Platform
Affymetrix Human Genome U133 Plus 2.0 Array [HG-U133_Plus_2]
Data Source
GSE10927