PIK3CA Expression Profiles in Chronic Kidney Disease and the Uremic Syndrom

Tool Box: Similarity Analysis

Select from the Gene Set

  •   41bb pathway[18]
  •   Ace2 pathway[14]
  •   Ach pathway[17]
  •   Actiny pathway[21]
  •   Agpcr pathway[14]
  •   Agr pathway[37]
  •   Ahsp pathway[14]
  •   Akap13 pathway[13]
  •   Akap95 pathway[13]
  •   Akapcentrosome pathway[16]
  •   Akt pathway[23]
  •   Alk pathway[38]
  •   Ami pathway[21]
  •   Arap pathway[19]
  •   Arenrf2 pathway[14]
  •   Arf pathway[18]
  •   Asbcell pathway[13]
  •   At1r pathway[37]
  •   Atm pathway[21]
  •   Atrbrca pathway[22]
  •   Bad pathway[27]
  •   Barr mapk pathway[13]
  •   Barrestin pathway[11]
  •   Barrestin src pathway[16]
  •   Bcellsurvival pathway[17]
  •   Bcr pathway[38]
  •   Biopeptides pathway[46]
  •   Blymphocyte pathway[12]
  •   Cacam pathway[17]
  •   Calcineurin pathway[22]
  •   Cardiacegf pathway[19]
  •   Carm er pathway[36]
  •   Carm1 pathway[14]
  •   Caspase pathway[24]
  •   Cbl pathway[14]
  •   Ccr3 pathway[24]
  •   Ccr5 pathway[21]
  •   Cd40 pathway[16]
  •   Cdc42rac pathway[17]
  •   Cdk5 pathway[12]
  •   Cdmac pathway[17]
  •   Cell2cell pathway[15]
  •   Cellcycle pathway[24]
  •   Ceramide pathway[23]
  •   Cftr pathway[13]
  •   Chemical pathway[23]
  •   Chrebp2 pathway[43]
  •   Ck1 pathway[18]
  •   Classic pathway[15]
  •   Comp pathway[20]
  •   Creb pathway[28]
  •   Csk pathway[25]
  •   Ctcf pathway[24]
  •   Ctl pathway[16]
  •   Ctla4 pathway[22]
  •   Cxcr4 pathway[25]
  •   Cytokine pathway[23]
  •   D4gdi pathway[14]
  •   Dc pathway[23]
  •   Death pathway[34]
  •   Dnafragment pathway[11]
  •   Dream pathway[15]
  •   Ecm pathway[25]
  •   Edg1 pathway[28]
  •   Egf pathway[32]
  •   Egfr smrte pathway[12]
  •   Eif pathway[17]
  •   Eif2 pathway[12]
  •   Eif4 pathway[25]
  •   Epha4 pathway[11]
  •   Epo pathway[20]
  •   Eponfkb pathway[12]
  •   Erk pathway[29]
  •   Erk5 pathway[19]
  •   Eryth pathway[16]
  •   Etc pathway[13]
  •   Ets pathway[19]
  •   Extrinsic pathway[14]
  •   Fas pathway[31]
  •   Fcer1 pathway[42]
  •   Feeder pathway[10]
  •   Fibrinolysis pathway[13]
  •   Fmlp pathway[40]
  •   Free pathway[11]
  •   G1 pathway[29]
  •   G2 pathway[25]
  •   Gaba pathway[11]
  •   Gata3 pathway[17]
  •   Gcr pathway[23]
  •   Gh pathway[29]
  •   Gleevec pathway[24]
  •   Glycolysis pathway[11]
  •   Gpcr pathway[38]
  •   Granulocytes pathway[15]
  •   Gsk3 pathway[28]
  •   Hcmv pathway[18]
  •   Hdac pathway[33]
  •   Her2 pathway[23]
  •   Hif pathway[16]
  •   Hivnef pathway[59]
  •   Hsp27 pathway[16]
  •   Igf1 pathway[22]
  •   Igf1mtor pathway[21]
  •   Igf1r pathway[24]
  •   Il10 pathway[18]
  •   Il12 pathway[24]
  •   Il17 pathway[18]
  •   Il1r pathway[34]
  •   Il2 pathway[23]
  •   Il22bp pathway[17]
  •   Il2rb pathway[39]
  •   Il3 pathway[16]
  •   Il4 pathway[12]
  •   Il5 pathway[11]
  •   Il6 pathway[23]
  •   Il7 pathway[18]
  •   Inflam pathway[30]
  •   Insulin pathway[23]
  •   Integrin pathway[39]
  •   Intrinsic pathway[24]
  •   Keratinocyte pathway[47]
  •   Kreb pathway[9]
  •   Lair pathway[18]
  •   Lectin pathway[13]
  •   Leptin pathway[12]
  •   Longevity pathway[16]
  •   Lym pathway[12]
  •   Mal pathway[20]
  •   Mapk pathway[88]
  •   Mcalpain pathway[26]
  •   Mcm pathway[19]
  •   Mef2d pathway[24]
  •   Met pathway[38]
  •   Mitochondria pathway[22]
  •   Monocyte pathway[12]
  •   Mpr pathway[35]
  •   Mta3 pathway[20]
  •   Mtor pathway[24]
  •   Myosin pathway[32]
  •   Ndkdynamin pathway[22]
  •   Neurotransmitters pathway[7]
  •   Nfat pathway[57]
  •   Nfkb pathway[24]
  •   Ngf pathway[19]
  •   Nkcells pathway[21]
  •   Nkt pathway[30]
  •   No1 pathway[34]
  •   No2il12 pathway[18]
  •   Nos1 pathway[25]
  •   Nthi pathway[25]
  •   Nuclearrs pathway[16]
  •   P27 pathway[14]
  •   P35alzheimers pathway[12]
  •   P38mapk pathway[41]
  •   P53 pathway[17]
  •   P53hypoxia pathway[24]
  •   Par1 pathway[38]
  •   Parkin pathway[14]
  •   Pdgf pathway[33]
  •   Pgc1a pathway[27]
  •   Pitx2 pathway[16]
  •   Plateletapp pathway[15]
  •   Plce pathway[13]
  •   Pml pathway[18]
  •   Ppara pathway[59]
  •   Proteasome pathway[29]
  •   Ps1 pathway[15]
  •   Ptc1 pathway[12]
  •   Ptdins pathway[24]
  •   Pten pathway[19]
  •   Pyk2 pathway[32]
  •   Rab pathway[13]
  •   Rac1 pathway[24]
  •   Raccycd pathway[27]
  •   Rankl pathway[15]
  •   Ranms pathway[11]
  •   Rarrxr pathway[16]
  •   Ras pathway[24]
  •   Rb pathway[14]
  •   Rela pathway[17]
  •   Rho pathway[33]
  •   Rna pathway[11]
  •   Salmonella pathway[14]
  •   Sars pathway[11]
  •   Set pathway[12]
  •   Shh pathway[17]
  •   Skp2e2f pathway[11]
  •   Sodd pathway[11]
  •   Sppa pathway[23]
  •   Spry pathway[19]
  •   Srcrptp pathway[12]
  •   Stathmin pathway[20]
  •   Stem pathway[16]
  •   Stress pathway[26]
  •   Tall1 pathway[16]
  •   Tcapoptosis pathway[12]
  •   Tcr pathway[50]
  •   Tcra pathway[14]
  •   Tcytotoxic pathway[15]
  •   Tel pathway[19]
  •   Tff pathway[22]
  •   Tgfb pathway[20]
  •   Th1th2 pathway[20]
  •   Thelper pathway[15]
  •   Tid pathway[20]
  •   Tnfr1 pathway[30]
  •   Tnfr2 pathway[19]
  •   Tob1 pathway[22]
  •   Toll pathway[38]
  •   Tpo pathway[25]
  •   Trka pathway[13]
  •   Ucalpain pathway[19]
  •   Vdr pathway[13]
  •   Vegf pathway[30]
  •   Vip pathway[30]
  •   Vitcb pathway[12]
  •   Wnt pathway[27]
  •   Abc transporters[45]
  •   Acute myeloid leukemia[61]
  •   Adherens junction[76]
  •   Adipocytokine signaling pathway[68]
  •   Alanine aspartate and glutamate metabolism[33]
  •   Aldosterone regulated sodium reabsorption[43]
  •   Allograft rejection[39]
  •   Alpha linolenic acid metabolism[20]
  •   Alzheimers disease[170]
  •   Amino sugar and nucleotide sugar metabolism[45]
  •   Aminoacyl trna biosynthesis[42]
  •   Amyotrophic lateral sclerosis als[54]
  •   Antigen processing and presentation[90]
  •   Apoptosis[89]
  •   Arachidonic acid metabolism[59]
  •   Arginine and proline metabolism[55]
  •   Arrhythmogenic right ventricular cardiomyopathy arvc[77]
  •   Ascorbate and aldarate metabolism[26]
  •   Asthma[31]
  •   Autoimmune thyroid disease[54]
  •   Axon guidance[130]
  •   B cell receptor signaling pathway[76]
  •   Basal cell carcinoma[56]
  •   Basal transcription factors[37]
  •   Base excision repair[36]
  •   Beta alanine metabolism[23]
  •   Biosynthesis of unsaturated fatty acids[23]
  •   Bladder cancer[43]
  •   Butanoate metabolism[35]
  •   Calcium signaling pathway[179]
  •   Cardiac muscle contraction[81]
  •   Cell adhesion molecules cams[135]
  •   Cell cycle[129]
  •   Chemokine signaling pathway[191]
  •   Chronic myeloid leukemia[74]
  •   Circadian rhythm mammal[14]
  •   Citrate cycle tca cycle[33]
  •   Colorectal cancer[63]
  •   Complement and coagulation cascades[70]
  •   Cysteine and methionine metabolism[35]
  •   Cytokine cytokine receptor interaction[268]
  •   Cytosolic dna sensing pathway[57]
  •   Dilated cardiomyopathy[93]
  •   Dna replication[37]
  •   Dorso ventral axis formation[26]
  •   Drug metabolism cytochrome p450[73]
  •   Drug metabolism other enzymes[52]
  •   Ecm receptor interaction[85]
  •   Endocytosis[184]
  •   Endometrial cancer[53]
  •   Epithelial cell signaling in helicobacter pylori infection[69]
  •   Erbb signaling pathway[88]
  •   Ether lipid metabolism[34]
  •   Fatty acid metabolism[43]
  •   Fc epsilon ri signaling pathway[80]
  •   Fc gamma r mediated phagocytosis[98]
  •   Focal adhesion[202]
  •   Folate biosynthesis[12]
  •   Fructose and mannose metabolism[35]
  •   Galactose metabolism[27]
  •   Gap junction[91]
  •   Glioma[66]
  •   Glutathione metabolism[51]
  •   Glycerolipid metabolism[50]
  •   Glycerophospholipid metabolism[78]
  •   Glycine serine and threonine metabolism[32]
  •   Glycolysis gluconeogenesis[63]
  •   Glycosaminoglycan biosynthesis chondroitin sulfate[23]
  •   Glycosaminoglycan biosynthesis heparan sulfate[27]
  •   Glycosaminoglycan biosynthesis keratan sulfate[16]
  •   Glycosaminoglycan degradation[22]
  •   Glycosphingolipid biosynthesis ganglio series[16]
  •   Glycosphingolipid biosynthesis globo series[15]
  •   Glycosphingolipid biosynthesis lacto and neolacto series[27]
  •   Glycosylphosphatidylinositol gpi anchor biosynthesis[26]
  •   Glyoxylate and dicarboxylate metabolism[17]
  •   Gnrh signaling pathway[102]
  •   Graft versus host disease[43]
  •   Hedgehog signaling pathway[57]
  •   Hematopoietic cell lineage[89]
  •   Histidine metabolism[30]
  •   Homologous recombination[29]
  •   Huntingtons disease[186]
  •   Hypertrophic cardiomyopathy hcm[86]
  •   Inositol phosphate metabolism[55]
  •   Insulin signaling pathway[138]
  •   Intestinal immune network for iga production[49]
  •   Jak stat signaling pathway[156]
  •   Leishmania infection[73]
  •   Leukocyte transendothelial migration[119]
  •   Limonene and pinene degradation[11]
  •   Linoleic acid metabolism[30]
  •   Long term depression[71]
  •   Long term potentiation[71]
  •   Lysine degradation[45]
  •   Lysosome[122]
  •   Mapk signaling pathway[268]
  •   Maturity onset diabetes of the young[26]
  •   Melanogenesis[103]
  •   Melanoma[72]
  •   Metabolism of xenobiotics by cytochrome p450[71]
  •   Mismatch repair[24]
  •   Mtor signaling pathway[53]
  •   N glycan biosynthesis[47]
  •   Natural killer cell mediated cytotoxicity[138]
  •   Neuroactive ligand receptor interaction[273]
  •   Neurotrophin signaling pathway[127]
  •   Nicotinate and nicotinamide metabolism[25]
  •   Nitrogen metabolism[24]
  •   Nod like receptor signaling pathway[63]
  •   Non homologous end joining[15]
  •   Non small cell lung cancer[55]
  •   Notch signaling pathway[48]
  •   Nucleotide excision repair[45]
  •   O glycan biosynthesis[31]
  •   Olfactory transduction[390]
  •   One carbon pool by folate[18]
  •   Oocyte meiosis[115]
  •   Other glycan degradation[17]
  •   Oxidative phosphorylation[136]
  •   P53 signaling pathway[70]
  •   Pancreatic cancer[71]
  •   Pantothenate and coa biosynthesis[17]
  •   Parkinsons disease[134]
  •   Pathogenic escherichia coli infection[60]
  •   Pathways in cancer[329]
  •   Pentose and glucuronate interconversions[29]
  •   Pentose phosphate pathway[28]
  •   Peroxisome[79]
  •   Phenylalanine metabolism[19]
  •   Phosphatidylinositol signaling system[77]
  •   Porphyrin and chlorophyll metabolism[42]
  •   Ppar signaling pathway[70]
  •   Primary bile acid biosynthesis[17]
  •   Primary immunodeficiency[36]
  •   Prion diseases[36]
  •   Progesterone mediated oocyte maturation[87]
  •   Propanoate metabolism[34]
  •   Prostate cancer[90]
  •   Proteasome[49]
  •   Protein export[25]
  •   Proximal tubule bicarbonate reclamation[24]
  •   Purine metabolism[160]
  •   Pyrimidine metabolism[99]
  •   Pyruvate metabolism[41]
  •   Regulation of actin cytoskeleton[217]
  •   Regulation of autophagy[36]
  •   Renal cell carcinoma[71]
  •   Renin angiotensin system[18]
  •   Retinol metabolism[65]
  •   Riboflavin metabolism[17]
  •   Ribosome[89]
  •   Rig i like receptor signaling pathway[72]
  •   Rna degradation[60]
  •   Rna polymerase[30]
  •   Selenoamino acid metabolism[27]
  •   Small cell lung cancer[85]
  •   Snare interactions in vesicular transport[39]
  •   Sphingolipid metabolism[41]
  •   Spliceosome[129]
  •   Starch and sucrose metabolism[53]
  •   Steroid biosynthesis[18]
  •   Steroid hormone biosynthesis[56]
  •   Sulfur metabolism[14]
  •   Systemic lupus erythematosus[141]
  •   T cell receptor signaling pathway[109]
  •   Taste transduction[53]
  •   Taurine and hypotaurine metabolism[11]
  •   Terpenoid backbone biosynthesis[16]
  •   Tgf beta signaling pathway[87]
  •   Thyroid cancer[30]
  •   Tight junction[135]
  •   Toll like receptor signaling pathway[103]
  •   Tryptophan metabolism[41]
  •   Type i diabetes mellitus[45]
  •   Type ii diabetes mellitus[48]
  •   Tyrosine metabolism[43]
  •   Ubiquitin mediated proteolysis[139]
  •   Valine leucine and isoleucine biosynthesis[12]
  •   Valine leucine and isoleucine degradation[45]
  •   Vascular smooth muscle contraction[116]
  •   Vasopressin regulated water reabsorption[45]
  •   Vegf signaling pathway[77]
  •   Vibrio cholerae infection[57]
  •   Viral myocarditis[74]
  •   Wnt signaling pathway[152]
  •   3 utr mediated translational regulation[177]
  •   A tetrasaccharide linker sequence is required for gag synthesis[26]
  •   Abacavir transport and metabolism[11]
  •   Abc family proteins mediated transport[35]
  •   Abca transporters in lipid homeostasis[19]
  •   Abortive elongation of hiv1 transcript in the absence of tat[24]
  •   Acetylcholine binding and downstream events[17]
  •   Acetylcholine neurotransmitter release cycle[11]
  •   Activated ampk stimulates fatty acid oxidation in muscle[20]
  •   Activated notch1 transmits signal to the nucleus[28]
  •   Activated point mutants of fgfr2[17]
  •   Activated tak1 mediates p38 mapk activation[19]
  •   Activated tlr4 signalling[94]
  •   Activation of atr in response to replication stress[39]
  •   Activation of bh3 only proteins[18]
  •   Activation of chaperone genes by atf6 alpha[12]
  •   Activation of chaperone genes by xbp1s[47]
  •   Activation of chaperones by atf6 alpha[14]
  •   Activation of genes by atf4[27]
  •   Activation of irf3 irf7 mediated by tbk1 ikk epsilon[15]
  •   Activation of kainate receptors upon glutamate binding[32]
  •   Activation of nf kappab in b cells[65]
  •   Activation of nmda receptor upon glutamate binding and postsynaptic events[38]
  •   Activation of rac[15]
  •   Activation of the ap1 family of transcription factors[11]
  •   Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s[85]
  •   Activation of the pre replicative complex[32]
  •   Acyl chain remodelling of pc[23]
  •   Acyl chain remodelling of pe[22]
  •   Acyl chain remodelling of pg[17]
  •   Acyl chain remodelling of pi[16]
  •   Acyl chain remodelling of ps[16]
  •   Adaptive immune system[540]
  •   Adenylate cyclase activating pathway[11]
  •   Adenylate cyclase inhibitory pathway[14]
  •   Adherens junctions interactions[28]
  •   Adp signalling through p2ry1[26]
  •   Adp signalling through p2ry12[22]
  •   Advanced glycosylation endproduct receptor signaling[14]
  •   Akt phosphorylates targets in the cytosol[13]
  •   Alpha linolenic acid ala metabolism[13]
  •   Amine compound slc transporters[28]
  •   Amine derived hormones[16]
  •   Amine ligand binding receptors[39]
  •   Amino acid and oligopeptide slc transporters[50]
  •   Amino acid synthesis and interconversion transamination[18]
  •   Amino acid transport across the plasma membrane[32]
  •   Amyloids[84]
  •   Androgen biosynthesis[11]
  •   Antigen activates b cell receptor leading to generation of second messengers[30]
  •   Antigen presentation folding assembly and peptide loading of class i mhc[22]
  •   Antigen processing cross presentation[77]
  •   Antigen processing ubiquitination proteasome degradation[213]
  •   Antiviral mechanism by ifn stimulated genes[67]
  •   Apc c cdc20 mediated degradation of cyclin b[27]
  •   Apc c cdc20 mediated degradation of mitotic proteins[74]
  •   Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1[73]
  •   Apc cdc20 mediated degradation of nek2a[29]
  •   Apobec3g mediated resistance to hiv1 infection[13]
  •   Apoptosis[149]
  •   Apoptosis induced dna fragmentation[14]
  •   Apoptotic cleavage of cell adhesion proteins[13]
  •   Apoptotic cleavage of cellular proteins[41]
  •   Apoptotic execution phase[55]
  •   Aquaporin mediated transport[52]
  •   Arms mediated activation[18]
  •   Asparagine n linked glycosylation[82]
  •   Assembly of the pre replicative complex[66]
  •   Association of licensing factors with the pre replicative complex[15]
  •   Association of tric cct with target proteins during biosynthesis[28]
  •   Autodegradation of cdh1 by cdh1 apc c[65]
  •   Autodegradation of the e3 ubiquitin ligase cop1[52]
  •   Axon guidance[252]
  •   Base excision repair[20]
  •   Base free sugar phosphate removal via the single nucleotide replacement pathway[11]
  •   Basigin interactions[31]
  •   Beta defensins[43]
  •   Bile acid and bile salt metabolism[28]
  •   Bile salt and organic anion slc transporters[12]
  •   Binding and entry of hiv virion[11]
  •   Biological oxidations[140]
  •   Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein[30]
  •   Bmal1 clock npas2 activates circadian expression[37]
  •   Botulinum neurotoxicity[20]
  •   Branched chain amino acid catabolism[18]
  •   Ca dependent events[31]
  •   Calnexin calreticulin cycle[12]
  •   Caspase mediated cleavage of cytoskeletal proteins[14]
  •   Cd28 co stimulation[33]
  •   Cd28 dependent pi3k akt signaling[23]
  •   Cd28 dependent vav1 pathway[12]
  •   Cdc6 association with the orc origin complex[12]
  •   Cdk mediated phosphorylation and removal of cdc6[49]
  •   Cdt1 association with the cdc6 orc origin complex[57]
  •   Cell cell communication[121]
  •   Cell cell junction organization[57]
  •   Cell cycle[422]
  •   Cell cycle checkpoints[125]
  •   Cell cycle mitotic[326]
  •   Cell death signalling via nrage nrif and nade[61]
  •   Cell extracellular matrix interactions[15]
  •   Cell junction organization[79]
  •   Cell surface interactions at the vascular wall[92]
  •   Cgmp effects[20]
  •   Chemokine receptors bind chemokines[58]
  •   Cholesterol biosynthesis[25]
  •   Chondroitin sulfate biosynthesis[22]
  •   Chondroitin sulfate dermatan sulfate metabolism[50]
  •   Chromosome maintenance[123]
  •   Chylomicron mediated lipid transport[17]
  •   Circadian clock[54]
  •   Circadian repression of expression by rev erba[24]
  •   Citric acid cycle tca cycle[27]
  •   Class a1 rhodopsin like receptors[306]
  •   Class b 2 secretin family receptors[89]
  •   Class c 3 metabotropic glutamate pheromone receptors[16]
  •   Class i mhc mediated antigen processing presentation[252]
  •   Cleavage of growing transcript in the termination region [45]
  •   Collagen formation[59]
  •   Common pathway[15]
  •   Complement cascade[33]
  •   Conversion from apc c cdc20 to apc c cdh1 in late anaphase[23]
  •   Copi mediated transport[11]
  •   Costimulation by the cd28 family[64]
  •   Creation of c4 and c2 activators[11]
  •   Creb phosphorylation through the activation of camkii[16]
  •   Creb phosphorylation through the activation of ras[28]
  •   Crmps in sema3a signaling[15]
  •   Cross presentation of soluble exogenous antigens endosomes[49]
  •   Cs ds degradation[13]
  •   Ctla4 inhibitory signaling[22]
  •   Ctnnb1 phosphorylation cascade[17]
  •   Cyclin a b1 associated events during g2 m transition[16]
  •   Cyclin e associated events during g1 s transition [66]
  •   Cytochrome p450 arranged by substrate type[52]
  •   Cytokine signaling in immune system[271]
  •   Cytosolic sulfonation of small molecules[15]
  •   Cytosolic trna aminoacylation[25]
  •   Dag and ip3 signaling[33]
  •   Darpp 32 events[26]
  •   Dcc mediated attractive signaling[14]
  •   Deadenylation dependent mrna decay[49]
  •   Deadenylation of mrna[23]
  •   Defensins[52]
  •   Degradation of the extracellular matrix[30]
  •   Deposition of new cenpa containing nucleosomes at the centromere[65]
  •   Destabilization of mrna by auf1 hnrnp d0[54]
  •   Destabilization of mrna by brf1[18]
  •   Destabilization of mrna by ksrp[18]
  •   Destabilization of mrna by tristetraprolin ttp[18]
  •   Developmental biology[397]
  •   Diabetes pathways[134]
  •   Digestion of dietary carbohydrate[13]
  •   Dna repair[113]
  •   Dna replication[193]
  •   Dna strand elongation[31]
  •   Dopamine neurotransmitter release cycle[12]
  •   Double strand break repair[25]
  •   Downregulation of erbb2 erbb3 signaling[13]
  •   Downregulation of smad2 3 smad4 transcriptional activity[21]
  •   Downregulation of tgf beta receptor signaling[24]
  •   Downstream signal transduction[96]
  •   Downstream signaling events of b cell receptor bcr[98]
  •   Downstream signaling of activated fgfr[101]
  •   Downstream tcr signaling[38]
  •   Dscam interactions[12]
  •   E2f enabled inhibition of pre replication complex formation[11]
  •   E2f mediated regulation of dna replication[36]
  •   Early phase of hiv life cycle[22]
  •   Effects of pip2 hydrolysis[26]
  •   Egfr downregulation[26]
  •   Eicosanoid ligand binding receptors[17]
  •   Elevation of cytosolic ca2 levels[11]
  •   Elongation arrest and recovery[33]
  •   Endogenous sterols[16]
  •   Endosomal sorting complex required for transport escrt[28]
  •   Endosomal vacuolar pathway[10]
  •   Energy dependent regulation of mtor by lkb1 ampk[19]
  •   Enos activation and regulation[21]
  •   Er phagosome pathway[62]
  •   Erk mapk targets[22]
  •   Erks are inactivated[13]
  •   Ethanol oxidation[11]
  •   Extension of telomeres[28]
  •   Extracellular matrix organization[88]
  •   Extrinsic pathway for apoptosis[14]
  •   Facilitative na independent glucose transporters[13]
  •   Factors involved in megakaryocyte development and platelet production[133]
  •   Fanconi anemia pathway[26]
  •   Fatty acid triacylglycerol and ketone body metabolism[169]
  •   Fatty acyl coa biosynthesis[19]
  •   Fgfr ligand binding and activation[23]
  •   Fgfr1 ligand binding and activation[15]
  •   Fgfr2c ligand binding and activation[13]
  •   Fgfr4 ligand binding and activation[13]
  •   Formation of atp by chemiosmotic coupling[17]
  •   Formation of fibrin clot clotting cascade[33]
  •   Formation of incision complex in gg ner[24]
  •   Formation of rna pol ii elongation complex [46]
  •   Formation of the hiv1 early elongation complex[35]
  •   Formation of the ternary complex and subsequently the 43s complex[75]
  •   Formation of transcription coupled ner tc ner repair complex[31]
  •   Formation of tubulin folding intermediates by cct tric[23]
  •   Frs2 mediated cascade[37]
  •   G alpha i signalling events[196]
  •   G alpha q signalling events[185]
  •   G alpha s signalling events[122]
  •   G alpha z signalling events[45]
  •   G alpha1213 signalling events[75]
  •   G beta gamma signalling through pi3kgamma[26]
  •   G beta gamma signalling through plc beta[21]
  •   G protein activation[28]
  •   G protein beta gamma signalling[29]
  •   G0 and early g1[26]
  •   G1 phase[39]
  •   G1 s specific transcription[20]
  •   G1 s transition[113]
  •   G2 m checkpoints[46]
  •   G2 m dna damage checkpoint[13]
  •   Gab1 signalosome[39]
  •   Gaba a receptor activation[13]
  •   Gaba b receptor activation[39]
  •   Gaba receptor activation[53]
  •   Gaba synthesis release reuptake and degradation[18]
  •   Gamma carboxylation transport and amino terminal cleavage of proteins[12]
  •   Gap junction assembly[19]
  •   Gap junction degradation[11]
  •   Gap junction trafficking[28]
  •   Gastrin creb signalling pathway via pkc and mapk[206]
  •   Generation of second messenger molecules[28]
  •   Generic transcription pathway[353]
  •   Global genomic ner gg ner[36]
  •   Glucagon signaling in metabolic regulation[35]
  •   Glucagon type ligand receptors[34]
  •   Gluconeogenesis[35]
  •   Glucose metabolism[70]
  •   Glucose transport[39]
  •   Glucuronidation[19]
  •   Glutamate neurotransmitter release cycle[16]
  •   Glutathione conjugation[24]
  •   Glycerophospholipid biosynthesis[83]
  •   Glycogen breakdown glycogenolysis[19]
  •   Glycolysis[30]
  •   Glycoprotein hormones[13]
  •   Glycosaminoglycan metabolism[112]
  •   Glycosphingolipid metabolism[39]
  •   Golgi associated vesicle biogenesis[54]
  •   Gpcr downstream signaling[806]
  •   Gpcr ligand binding[409]
  •   Gpvi mediated activation cascade[32]
  •   Grb2 events in erbb2 signaling[23]
  •   Grb2 sos provides linkage to mapk signaling for intergrins [16]
  •   Growth hormone receptor signaling[25]
  •   Hdl mediated lipid transport[16]
  •   Hemostasis[467]
  •   Heparan sulfate heparin hs gag metabolism[53]
  •   Highly calcium permeable postsynaptic nicotinic acetylcholine receptors[14]
  •   Hiv infection[208]
  •   Hiv life cycle[126]
  •   Homologous recombination repair of replication independent double strand breaks[18]
  •   Hormone ligand binding receptors[11]
  •   Hormone sensitive lipase hsl mediated triacylglycerol hydrolysis[14]
  •   Host interactions of hiv factors[133]
  •   Hs gag biosynthesis[32]
  •   Hs gag degradation[21]
  •   Hyaluronan metabolism[15]
  •   Hyaluronan uptake and degradation[11]
  •   Ikk complex recruitment mediated by rip1[11]
  •   Il 2 signaling[42]
  •   Il 3 5 and gm csf signaling[44]
  •   Il 6 signaling[12]
  •   Il 7 signaling[12]
  •   Il receptor shc signaling[28]
  •   Il1 signaling[40]
  •   Immune system[934]
  •   Immunoregulatory interactions between a lymphoid and a non lymphoid cell[71]
  •   Incretin synthesis secretion and inactivation[23]
  •   Inflammasomes[18]
  •   Influenza life cycle[204]
  •   Influenza viral rna transcription and replication[170]
  •   Inhibition of insulin secretion by adrenaline noradrenaline[26]
  •   Inhibition of replication initiation of damaged dna by rb1 e2f1[14]
  •   Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components[25]
  •   Inhibition of voltage gated ca2 channels via gbeta gamma subunits[26]
  •   Initial triggering of complement[17]
  •   Innate immune system[280]
  •   Insulin receptor recycling[24]
  •   Insulin receptor signalling cascade[88]
  •   Insulin synthesis and processing[22]
  •   Integration of energy metabolism[121]
  •   Integration of provirus[17]
  •   Integrin alphaiib beta3 signaling[28]
  •   Integrin cell surface interactions[80]
  •   Interaction between l1 and ankyrins[24]
  •   Interactions of vpr with host cellular proteins[34]
  •   Interferon alpha beta signaling[65]
  •   Interferon gamma signaling[64]
  •   Interferon signaling[160]
  •   Intrinsic pathway[18]
  •   Intrinsic pathway for apoptosis[31]
  •   Inwardly rectifying k channels[32]
  •   Ion channel transport[56]
  •   Ion transport by p type atpases[35]
  •   Ionotropic activity of kainate receptors[12]
  •   Irak1 recruits ikk complex[11]
  •   Irak2 mediated activation of tak1 complex upon tlr7 8 or 9 stimulation[10]
  •   Iron uptake and transport[37]
  •   Jnk c jun kinases phosphorylation and activation mediated by activated human tak1[17]
  •   Keratan sulfate biosynthesis[27]
  •   Keratan sulfate degradation[12]
  •   Keratan sulfate keratin metabolism[31]
  •   Kinesins[25]
  •   L1cam interactions[87]
  •   Lagging strand synthesis[20]
  •   Late phase of hiv life cycle[105]
  •   Latent infection of homo sapiens with mycobacterium tuberculosis[34]
  •   Ligand gated ion channel transport[22]
  •   Lipid digestion mobilization and transport[47]
  •   Lipoprotein metabolism[29]
  •   Loss of nlp from mitotic centrosomes[60]
  •   Lysosome vesicle biogenesis[24]
  •   M g1 transition[82]
  •   Map kinase activation in tlr cascade[51]
  •   Mapk targets nuclear events mediated by map kinases[31]
  •   Meiosis[117]
  •   Meiotic recombination[87]
  •   Meiotic synapsis[74]
  •   Membrane binding and targetting of gag proteins[11]
  •   Membrane trafficking[130]
  •   Metabolism of amino acids and derivatives[201]
  •   Metabolism of carbohydrates[248]
  •   Metabolism of lipids and lipoproteins[479]
  •   Metabolism of mrna[285]
  •   Metabolism of non coding rna[50]
  •   Metabolism of nucleotides[73]
  •   Metabolism of polyamines[16]
  •   Metabolism of porphyrins[15]
  •   Metabolism of proteins[519]
  •   Metabolism of rna[331]
  •   Metabolism of steroid hormones and vitamins a and d[36]
  •   Metabolism of vitamins and cofactors[52]
  •   Metal ion slc transporters[23]
  •   Mhc class ii antigen presentation[92]
  •   Microrna mirna biogenesis[24]
  •   Mitochondrial fatty acid beta oxidation[15]
  •   Mitochondrial protein import[59]
  •   Mitochondrial trna aminoacylation[22]
  •   Mitotic g1 g1 s phases[138]
  •   Mitotic g2 g2 m phases[82]
  •   Mitotic m m g1 phases[173]
  •   Mitotic prometaphase[88]
  •   Mrna 3 end processing[36]
  •   Mrna capping[31]
  •   Mrna decay by 3 to 5 exoribonuclease[12]
  •   Mrna decay by 5 to 3 exoribonuclease[16]
  •   Mrna processing[162]
  •   Mrna splicing[112]
  •   Mrna splicing minor pathway[46]
  •   Mtorc1 mediated signalling[12]
  •   Muscle contraction[49]
  •   Myd88 mal cascade initiated on plasma membrane[84]
  •   Myogenesis[29]
  •   N glycan antennae elongation[15]
  •   N glycan antennae elongation in the medial trans golgi[19]
  •   N glycan trimming in the er and calnexin calreticulin cycle[14]
  •   Na cl dependent neurotransmitter transporters[18]
  •   Ncam signaling for neurite out growth[65]
  •   Ncam1 interactions[40]
  •   Nef mediated downregulation of mhc class i complex cell surface expression[11]
  •   Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters[22]
  •   Negative regulation of fgfr signaling[38]
  •   Negative regulation of the pi3k akt network[10]
  •   Negative regulators of rig i mda5 signaling[32]
  •   Nep ns2 interacts with the cellular export machinery[28]
  •   Nephrin interactions[21]
  •   Netrin1 signaling[42]
  •   Neuronal system[280]
  •   Neurotransmitter receptor binding and downstream transmission in the postsynaptic cell[138]
  •   Neurotransmitter release cycle[35]
  •   Nfkb activation through fadd rip1 pathway mediated by caspase 8 and10[13]
  •   Nfkb and map kinases activation mediated by tlr4 signaling repertoire[73]
  •   Nfkb is activated and signals survival[12]
  •   Ngf signalling via trka from the plasma membrane[138]
  •   Nitric oxide stimulates guanylate cyclase[26]
  •   Nod1 2 signaling pathway[31]
  •   Nonsense mediated decay enhanced by the exon junction complex[177]
  •   Norepinephrine neurotransmitter release cycle[11]
  •   Notch hlh transcription pathway[14]
  •   Notch1 intracellular domain regulates transcription[47]
  •   Nrage signals death through jnk[44]
  •   Nrif signals cell death from the nucleus[16]
  •   Nuclear events kinase and transcription factor activation[25]
  •   Nuclear receptor transcription pathway[50]
  •   Nuclear signaling by erbb4[39]
  •   Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways[47]
  •   Nucleotide excision repair[52]
  •   Nucleotide like purinergic receptors[17]
  •   O linked glycosylation of mucins[60]
  •   Olfactory signaling pathway[329]
  •   Opioid signalling[79]
  •   Opsins[11]
  •   Orc1 removal from chromatin[68]
  •   Organic cation anion zwitterion transport[14]
  •   Other semaphorin interactions[16]
  •   Oxygen dependent proline hydroxylation of hypoxia inducible factor alpha[19]
  •   P130cas linkage to mapk signaling for integrins[16]
  •   P2y receptors[13]
  •   P38mapk events[14]
  •   P53 dependent g1 dna damage response[58]
  •   P53 independent g1 s dna damage checkpoint[52]
  •   P75 ntr receptor mediated signalling[82]
  •   P75ntr recruits signalling complexes[13]
  •   P75ntr signals via nfkb[15]
  •   Packaging of telomere ends[49]
  •   Passive transport by aquaporins[12]
  •   Pd1 signaling[19]
  •   Pecam1 interactions[11]
  •   Peptide chain elongation[154]
  •   Peptide hormone biosynthesis[15]
  •   Peptide ligand binding receptors[189]
  •   Perk regulated gene expression[30]
  •   Peroxisomal lipid metabolism[22]
  •   Phase ii conjugation[71]
  •   Phase1 functionalization of compounds[71]
  •   Phospholipase c mediated cascade[55]
  •   Phospholipid metabolism[199]
  •   Phosphorylation of cd3 and tcr zeta chains[17]
  •   Phosphorylation of the apc c[24]
  •   Pi 3k cascade[57]
  •   Pi metabolism[49]
  •   Pi3k akt activation[39]
  •   Pi3k cascade[72]
  •   Pi3k events in erbb2 signaling[45]
  •   Pi3k events in erbb4 signaling[39]
  •   Pip3 activates akt signaling[30]
  •   Pka mediated phosphorylation of creb[19]
  •   Pkb mediated events[30]
  •   Platelet activation signaling and aggregation[209]
  •   Platelet adhesion to exposed collagen[13]
  •   Platelet aggregation plug formation[37]
  •   Platelet calcium homeostasis[19]
  •   Platelet homeostasis[79]
  •   Platelet sensitization by ldl[17]
  •   Plc beta mediated events[44]
  •   Pol switching[14]
  •   Post chaperonin tubulin folding pathway[20]
  •   Post nmda receptor activation events[34]
  •   Post translational modification synthesis of gpi anchored proteins[27]
  •   Post translational protein modification[189]
  •   Potassium channels[99]
  •   Ppara activates gene expression[105]
  •   Pre notch expression and processing[45]
  •   Pre notch processing in golgi[17]
  •   Pre notch transcription and translation[30]
  •   Prefoldin mediated transfer of substrate to cct tric[29]
  •   Presynaptic nicotinic acetylcholine receptors[13]
  •   Processing of capped intron containing pre mrna[141]
  •   Processing of capped intronless pre mrna[24]
  •   Processing of intronless pre mrnas[15]
  •   Processive synthesis on the lagging strand[16]
  •   Prolactin receptor signaling[15]
  •   Prolonged erk activation events[20]
  •   Prostacyclin signalling through prostacyclin receptor[20]
  •   Prostanoid ligand receptors[11]
  •   Protein folding[54]
  •   Proteolytic cleavage of snare complex proteins[18]
  •   Ptm gamma carboxylation hypusine formation and arylsulfatase activation[28]
  •   Purine catabolism[11]
  •   Purine metabolism[34]
  •   Purine ribonucleoside monophosphate biosynthesis[12]
  •   Purine salvage[14]
  •   Pyrimidine catabolism[13]
  •   Pyrimidine metabolism[25]
  •   Pyruvate metabolism[20]
  •   Pyruvate metabolism and citric acid tca cycle[49]
  •   Raf map kinase cascade[11]
  •   Rap1 signalling[18]
  •   Ras activation uopn ca2 infux through nmda receptor[18]
  •   Receptor ligand binding initiates the second proteolytic cleavage of notch receptor[13]
  •   Recruitment of mitotic centrosome proteins and complexes[67]
  •   Recruitment of numa to mitotic centrosomes[11]
  •   Recycling of bile acids and salts[12]
  •   Recycling pathway of l1[28]
  •   Regulated proteolysis of p75ntr[11]
  •   Regulation of ampk activity via lkb1[16]
  •   Regulation of apoptosis[59]
  •   Regulation of beta cell development[31]
  •   Regulation of complement cascade[15]
  •   Regulation of gene expression in beta cells[21]
  •   Regulation of glucokinase by glucokinase regulatory protein[28]
  •   Regulation of hypoxia inducible factor hif by oxygen[26]
  •   Regulation of ifna signaling[25]
  •   Regulation of ifng signaling[15]
  •   Regulation of insulin like growth factor igf activity by insulin like growth factor binding proteins igfbps[17]
  •   Regulation of insulin secretion[94]
  •   Regulation of insulin secretion by acetylcholine[12]
  •   Regulation of insulin secretion by glucagon like peptide1[44]
  •   Regulation of kit signaling[18]
  •   Regulation of mitotic cell cycle[86]
  •   Regulation of mrna stability by proteins that bind au rich elements[85]
  •   Regulation of ornithine decarboxylase odc[50]
  •   Regulation of pyruvate dehydrogenase pdh complex[14]
  •   Regulation of rheb gtpase activity by ampk[11]
  •   Regulation of signaling by cbl[19]
  •   Regulation of the fanconi anemia pathway[12]
  •   Regulation of water balance by renal aquaporins[45]
  •   Regulatory rna pathways[27]
  •   Removal of the flap intermediate from the c strand[11]
  •   Repair synthesis for gap filling by dna pol in tc ner[15]
  •   Resolution of ap sites via the multiple nucleotide patch replacement pathway[18]
  •   Resolution of ap sites via the single nucleotide replacement pathway[13]
  •   Respiratory electron transport[80]
  •   Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins [99]
  •   Response to elevated platelet cytosolic ca2 [90]
  •   Retrograde neurotrophin signalling[14]
  •   Reversible hydration of carbon dioxide[13]
  •   Rig i mda5 mediated induction of ifn alpha beta pathways[74]
  •   Rip mediated nfkb activation via dai[19]
  •   Rna pol i promoter opening[63]
  •   Rna pol i rna pol iii and mitochondrial transcription[123]
  •   Rna pol i transcription[90]
  •   Rna pol i transcription initiation[26]
  •   Rna pol i transcription termination[23]
  •   Rna pol ii pre transcription events[62]
  •   Rna pol ii transcription[106]
  •   Rna pol ii transcription pre initiation and promoter opening[42]
  •   Rna pol iii chain elongation[18]
  •   Rna pol iii transcription[34]
  •   Rna pol iii transcription initiation from type 2 promoter[24]
  •   Rna pol iii transcription initiation from type 3 promoter[27]
  •   Rna pol iii transcription termination[20]
  •   Role of dcc in regulating apoptosis[11]
  •   Role of second messengers in netrin1 signaling[12]
  •   Rora activates circadian expression[25]
  •   S phase[110]
  •   Scf beta trcp mediated degradation of emi1[52]
  •   Scfskp2 mediated degradation of p27 p21[57]
  •   Sema3a pak dependent axon repulsion[16]
  •   Sema3a plexin repulsion signaling by inhibiting integrin adhesion[14]
  •   Sema4d in semaphorin signaling[33]
  •   Sema4d induced cell migration and growth cone collapse[28]
  •   Semaphorin interactions[69]
  •   Serotonin receptors[13]
  •   Shc mediated cascade[29]
  •   Shc mediated signalling[16]
  •   Shc related events[18]
  •   Shc1 events in egfr signaling[16]
  •   Shc1 events in erbb4 signaling[21]
  •   Signal amplification[32]
  •   Signal attenuation[15]
  •   Signal regulatory protein sirp family interactions[13]
  •   Signal transduction by l1[35]
  •   Signaling by activated point mutants of fgfr1[12]
  •   Signaling by bmp[24]
  •   Signaling by constitutively active egfr[19]
  •   Signaling by egfr in cancer[110]
  •   Signaling by erbb2[102]
  •   Signaling by erbb4[91]
  •   Signaling by fgfr[113]
  •   Signaling by fgfr in disease[128]
  •   Signaling by fgfr mutants[45]
  •   Signaling by fgfr1 fusion mutants[20]
  •   Signaling by fgfr1 mutants[31]
  •   Signaling by fgfr3 mutants[12]
  •   Signaling by gpcr[921]
  •   Signaling by hippo[23]
  •   Signaling by ils[108]
  •   Signaling by insulin receptor[109]
  •   Signaling by nodal[19]
  •   Signaling by notch[104]
  •   Signaling by notch1[71]
  •   Signaling by notch2[13]
  •   Signaling by notch3[13]
  •   Signaling by notch4[13]
  •   Signaling by pdgf[123]
  •   Signaling by rho gtpases[114]
  •   Signaling by robo receptor[31]
  •   Signaling by scf kit[79]
  •   Signaling by tgf beta receptor complex[64]
  •   Signaling by the b cell receptor bcr[127]
  •   Signaling by wnt[66]
  •   Signalling by ngf[218]
  •   Signalling to erks[37]
  •   Signalling to p38 via rit and rin[16]
  •   Signalling to ras[28]
  •   Slbp dependent processing of replication dependent histone pre mrnas[12]
  •   Slc mediated transmembrane transport[242]
  •   Smad2 smad3 smad4 heterotrimer regulates transcription[28]
  •   Smooth muscle contraction[26]
  •   Sos mediated signalling[15]
  •   Sphingolipid de novo biosynthesis[32]
  •   Sphingolipid metabolism[70]
  •   Spry regulation of fgf signaling[15]
  •   Srp dependent cotranslational protein targeting to membrane[180]
  •   Steroid hormones[30]
  •   Striated muscle contraction[28]
  •   Sulfur amino acid metabolism[25]
  •   Synthesis and interconversion of nucleotide di and triphosphates[20]
  •   Synthesis of bile acids and bile salts[20]
  •   Synthesis of bile acids and bile salts via 24 hydroxycholesterol[11]
  •   Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol[16]
  •   Synthesis of dna[93]
  •   Synthesis of glycosylphosphatidylinositol gpi[18]
  •   Synthesis of pa[28]
  •   Synthesis of pc[19]
  •   Synthesis of pe[12]
  •   Synthesis of pips at the early endosome membrane[13]
  •   Synthesis of pips at the golgi membrane[18]
  •   Synthesis of pips at the late endosome membrane[11]
  •   Synthesis of pips at the plasma membrane[32]
  •   Synthesis of substrates in n glycan biosythesis[15]
  •   Synthesis of very long chain fatty acyl coas[15]
  •   Synthesis secretion and deacylation of ghrelin[17]
  •   Synthesis secretion and inactivation of gip[15]
  •   Synthesis secretion and inactivation of glp1[20]
  •   Tak1 activates nfkb by phosphorylation and activation of ikks complex[24]
  •   Tandem pore domain potassium channels[13]
  •   Tca cycle and respiratory electron transport[142]
  •   Tcr signaling[55]
  •   Telomere maintenance[76]
  •   Termination of o glycan biosynthesis[25]
  •   Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation[14]
  •   Tgf beta receptor signaling activates smads[27]
  •   Tgf beta receptor signaling in emt epithelial to mesenchymal transition[17]
  •   The activation of arylsulfatases[13]
  •   The nlrp3 inflammasome[13]
  •   The role of nef in hiv1 replication and disease pathogenesis[29]
  •   Thrombin signalling through proteinase activated receptors pars[33]
  •   Thromboxane signalling through tp receptor[24]
  •   Tie2 signaling[18]
  •   Tight junction interactions[30]
  •   Toll receptor cascades[119]
  •   Traf3 dependent irf activation pathway[15]
  •   Traf6 mediated induction of nfkb and map kinases upon tlr7 8 or 9 activation[78]
  •   Traf6 mediated induction of tak1 complex[15]
  •   Traf6 mediated irf7 activation[31]
  •   Traf6 mediated irf7 activation in tlr7 8 or 9 signaling[11]
  •   Traf6 mediated nfkb activation[22]
  •   Trafficking and processing of endosomal tlr[15]
  •   Trafficking of ampa receptors[29]
  •   Trafficking of glur2 containing ampa receptors[17]
  •   Trans golgi network vesicle budding[61]
  •   Transcription[211]
  •   Transcription coupled ner tc ner[46]
  •   Transcriptional activity of smad2 smad3 smad4 heterotrimer[39]
  •   Transcriptional regulation of white adipocyte differentiation[73]
  •   Transferrin endocytosis and recycling[26]
  •   Translation[223]
  •   Translocation of zap 70 to immunological synapse[15]
  •   Transmembrane transport of small molecules[414]
  •   Transmission across chemical synapses[187]
  •   Transport of glucose and other sugars bile salts and organic acids metal ions and amine compounds[90]
  •   Transport of inorganic cations anions and amino acids oligopeptides[95]
  •   Transport of mature mrna derived from an intronless transcript[34]
  •   Transport of mature transcript to cytoplasm[55]
  •   Transport of organic anions[12]
  •   Transport of ribonucleoproteins into the host nucleus[28]
  •   Transport of vitamins nucleosides and related molecules[32]
  •   Transport to the golgi and subsequent modification[34]
  •   Trif mediated tlr3 signaling[75]
  •   Triglyceride biosynthesis[39]
  •   Trna aminoacylation[43]
  •   Tryptophan catabolism[12]
  •   Unblocking of nmda receptor glutamate binding and activation[16]
  •   Unfolded protein response[81]
  •   Unwinding of dna[12]
  •   Vegf ligand receptor interactions[11]
  •   Vif mediated degradation of apobec3g[53]
  •   Viral messenger rna synthesis[15]
  •   Vitamin b5 pantothenate metabolism[12]
  •   Voltage gated potassium channels[44]
  •   Xenobiotics[17]
  •   Yap1 and wwtr1 taz stimulated gene expression[25]
  •   Zinc transporters[16]
Sample Grouping
1 GSM912836 WB_Normal1 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 48Sex: Frace: Caucasian
2 GSM912837 WB_Normal2 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 61Sex: Mrace: Caucasian
3 GSM912838 WB_Normal3 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 26Sex: Mrace: Caucasian
4 GSM912839 WB_Normal4 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 43Sex: Mrace: Caucasian
5 GSM912840 WB_Normal5 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 43Sex: Frace: Caucasian
6 GSM912841 WB_Normal6 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 26Sex: Frace: Caucasian
7 GSM912842 WB_Normal7 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 31Sex: Frace: Asian Oriental
8 GSM912843 WB_Normal8 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 32Sex: Mrace: Caucasian
9 GSM912844 WB_Normal9 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 43Sex: Mrace: Caucasian
10 GSM912845 WB_Normal10 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 43Sex: Frace: Caucasian
11 GSM912846 WB_Normal11 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 34Sex: Frace: Caucasian
12 GSM912847 WB_Normal12 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 46Sex: Mrace: Caucasian
13 GSM912848 WB_Normal13 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 42Sex: Mrace: Caucasian
14 GSM912849 WB_Normal14 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 26Sex: Mrace: Other/multiracial
15 GSM912850 WB_Normal15 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 47Sex: Frace: Asian Oriental
16 GSM912851 WB_Normal16 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 65Sex: Frace: Asian Oriental
17 GSM912852 WB_Normal17 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 54Sex: Mrace: Caucasian
18 GSM912853 WB_Normal18 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 41Sex: Mrace: Caucasian
19 GSM912854 WB_Normal19 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 41Sex: Mrace: Caucasian
20 GSM912855 WB_Normal20 [discovery]disease state: healthy controltissue: whole blood (WB)age_tx: 57Sex: Mrace: Caucasian
21 GSM912856 WB_Normal1 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 48Sex: Frace: Caucasian
22 GSM912857 WB_Normal2 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 61Sex: Mrace: Caucasian
23 GSM912858 WB_Normal3 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 26Sex: Mrace: Caucasian
24 GSM912859 WB_Normal4 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 43Sex: Mrace: Caucasian
25 GSM912860 WB_Normal5 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 43Sex: Frace: Caucasian
26 GSM912861 WB_Normal6 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 26Sex: Frace: Caucasian
27 GSM912862 WB_Normal7 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 31Sex: Frace: Asian Oriental
28 GSM912863 WB_Normal8 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 32Sex: Mrace: Caucasian
29 GSM912864 WB_Normal9 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 43Sex: Mrace: Caucasian
30 GSM912865 WB_Normal10 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 43Sex: Frace: Caucasian
31 GSM912866 WB_Normal11 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 34Sex: Frace: Caucasian
32 GSM912867 WB_Normal12 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 46Sex: Mrace: Caucasian
33 GSM912868 WB_Normal13 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 42Sex: Mrace: Caucasian
34 GSM912869 WB_Normal14 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 26Sex: Mrace: Other/multiracial
35 GSM912870 WB_Normal15 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 47Sex: Frace: Asian Oriental
36 GSM912871 WB_Normal16 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 65Sex: Frace: Asian Oriental
37 GSM912872 WB_Normal17 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 54Sex: Mrace: Caucasian
38 GSM912873 WB_Normal18 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 41Sex: Mrace: Caucasian
39 GSM912874 WB_Normal19 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 41Sex: Mrace: Caucasian
40 GSM912875 WB_Normal20 [validation]disease state: healthy controltissue: whole blood (WB)age_tx: 57Sex: Mrace: Caucasian
1 GSM912761 WB_Uremia1 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 47.4Sex: Frace: Caucasiandial_type: Conventional Haemo
2 GSM912762 WB_Uremia2 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 37.3Sex: Mrace: Asian Indiandial_type: Pre Dialysis
3 GSM912763 WB_Uremia3 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 36.4Sex: Mrace: Caucasiandial_type: CAPD
4 GSM912764 WB_Uremia4 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 29.9Sex: Frace: Caucasiandial_type: Conventional Haemo
5 GSM912765 WB_Uremia5 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 58.1Sex: Mrace: Asian Indiandial_type: CCPD (Automated PD)
6 GSM912766 WB_Uremia6 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 55.7Sex: Mrace: Caucasiandial_type: CAPD
7 GSM912767 WB_Uremia7 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 57.8Sex: Mrace: Caucasiandial_type: CAPD
8 GSM912768 WB_Uremia8 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 50Sex: Mrace: North American Indiandial_type: CAPD
9 GSM912769 WB_Uremia9 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 43.2Sex: Frace: Caucasiandial_type: Conventional Haemo
10 GSM912770 WB_Uremia10 [validation]disease state: uremiatissue: whole blood (WB)age_tx: 52.6Sex: Frace: Caucasiandial_type: Conventional Haemo
11 GSM912771 WB_Uremia11 [validation]disease state: uremiatissue: whole blood (WB)age_tx: 38.8Sex: Frace: Asian Indiandial_type: CAPD
12 GSM912772 WB_Uremia12 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 30Sex: Mrace: Asian Indiandial_type: Conventional Haemo
13 GSM912773 WB_Uremia13 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 55.4Sex: Mrace: Caucasiandial_type: Pre Dialysis
14 GSM912774 WB_Uremia14 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 31.8Sex: Mrace: Caucasiandial_type: CCPD (Automated PD)
15 GSM912775 WB_Uremia15 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 52.2Sex: Frace: Asian Indiandial_type: CCPD (Automated PD)
16 GSM912776 WB_Uremia16 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 37Sex: Mrace: Caucasiandial_type: CCPD (Automated PD)
17 GSM912777 WB_Uremia17 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 23.2Sex: Mrace: Asian Filipinodial_type: Conventional Haemo
18 GSM912778 WB_Uremia18 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 27Sex: Mrace: Caucasiandial_type: Conventional Haemo
19 GSM912779 WB_Uremia19 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 50.2Sex: Mrace: Caucasiandial_type: Conventional Haemo
20 GSM912780 WB_Uremia20 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 50.3Sex: Mrace: Caucasiandial_type: CAPD
21 GSM912781 WB_Uremia21 [validation]disease state: uremiatissue: whole blood (WB)age_tx: 58.7Sex: Mrace: Caucasiandial_type: Slow Nocturnal Haemo
22 GSM912782 WB_Uremia22 [validation]disease state: uremiatissue: whole blood (WB)age_tx: 57.5Sex: Mrace: Caucasiandial_type: Slow Nocturnal Haemo
23 GSM912783 WB_Uremia23 [validation]disease state: uremiatissue: whole blood (WB)age_tx: 34.5Sex: Mrace: Asian Orientaldial_type: Conventional Haemo
24 GSM912784 WB_Uremia24 [validation]disease state: uremiatissue: whole blood (WB)age_tx: 38Sex: Mrace: Caucasiandial_type: Pre Dialysis
25 GSM912785 WB_Uremia25 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 42.3Sex: Mrace: Caucasiandial_type: Pre Dialysis
26 GSM912786 WB_Uremia26 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 56.4Sex: Frace: Caucasiandial_type: Pre Dialysis
27 GSM912787 WB_Uremia27 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 51.1Sex: Mrace: Caucasiandial_type: Conventional Haemo
28 GSM912788 WB_Uremia28 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 64.6Sex: Mrace: Asian Indiandial_type: Conventional Haemo
29 GSM912789 WB_Uremia29 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 55.2Sex: Frace: Caucasiandial_type: CAPD
30 GSM912790 WB_Uremia30 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 55.3Sex: Frace: North American Indiandial_type: Conventional Haemo
31 GSM912791 WB_Uremia31 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 45.1Sex: Mrace: Caucasiandial_type: Conventional Haemo
32 GSM912792 WB_Uremia32 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 58.6Sex: Mrace: Caucasiandial_type: Conventional Haemo
33 GSM912793 WB_Uremia33 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 57.1Sex: Mrace: Asian Orientaldial_type: Conventional Haemo
34 GSM912794 WB_Uremia34 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 61.6Sex: Mrace: Caucasiandial_type: Conventional Haemo
35 GSM912795 WB_Uremia35 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 55.2Sex: Mrace: Caucasiandial_type: Pre Dialysis
36 GSM912796 WB_Uremia36 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 37.9Sex: Mrace: Caucasiandial_type: CAPD
37 GSM912797 WB_Uremia37 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 47.9Sex: Mrace: Caucasiandial_type: CCPD (Automated PD)
38 GSM912798 WB_Uremia38 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 51.4Sex: Mrace: Asian Indiandial_type: Pre Dialysis
39 GSM912799 WB_Uremia39 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 50.8Sex: Frace: Caucasiandial_type: Conventional Haemo
40 GSM912800 WB_Uremia40 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 29Sex: Frace: Caucasiandial_type: Conventional Haemo
41 GSM912801 WB_Uremia41 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 60.4Sex: Frace: North American Indiandial_type: Pre Dialysis
42 GSM912802 WB_Uremia42 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 60Sex: Mrace: Caucasiandial_type: Conventional Haemo
43 GSM912803 WB_Uremia43 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 38.4Sex: Mrace: Asian Indiandial_type: CCPD (Automated PD)
44 GSM912804 WB_Uremia44 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 40.1Sex: Mrace: Caucasiandial_type: Pre Dialysis
45 GSM912805 WB_Uremia45 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 46.6Sex: Frace: Caucasiandial_type: CCPD (Automated PD)
46 GSM912806 WB_Uremia46 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 60.9Sex: Frace: Caucasiandial_type: Conventional Haemo
47 GSM912807 WB_Uremia47 [validation]disease state: uremiatissue: whole blood (WB)age_tx: 42Sex: Frace: Caucasiandial_type: Pre Dialysis
48 GSM912808 WB_Uremia48 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 58.5Sex: Mrace: Caucasiandial_type: PD Combined with Haemo
49 GSM912809 WB_Uremia49 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 44.8Sex: Frace: Caucasiandial_type: Conventional Haemo
50 GSM912810 WB_Uremia50 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 35.9Sex: Frace: Asian Filipinodial_type: CAPD
51 GSM912811 WB_Uremia51 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 58.6Sex: Frace: Caucasiandial_type: CAPD
52 GSM912812 WB_Uremia52 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 45.4Sex: Mrace: Caucasiandial_type: Conventional Haemo
53 GSM912813 WB_Uremia53 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 47.3Sex: Frace: Caucasiandial_type: Conventional Haemo
54 GSM912814 WB_Uremia54 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 49.5Sex: Mrace: Caucasiandial_type: Pre Dialysis
55 GSM912815 WB_Uremia55 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 32.4Sex: Mrace: Caucasiandial_type: Pre Dialysis
56 GSM912816 WB_Uremia56 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 35.5Sex: Frace: Caucasiandial_type: Conventional Haemo
57 GSM912817 WB_Uremia57 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 30.3Sex: Mrace: North American Indiandial_type: Conventional Haemo
58 GSM912818 WB_Uremia58 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 51.8Sex: Frace: Caucasiandial_type: Pre Dialysis
59 GSM912819 WB_Uremia59 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 56.4Sex: Mrace: Blackdial_type: Conventional Haemo
60 GSM912820 WB_Uremia60 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 24.5Sex: Mrace: Caucasiandial_type: Conventional Haemo
61 GSM912821 WB_Uremia61 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 56.8Sex: Mrace: Asian Orientaldial_type: Slow Nocturnal Haemo
62 GSM912822 WB_Uremia62 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 20.7Sex: Mrace: Caucasiandial_type: Pre Dialysis
63 GSM912823 WB_Uremia63 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 65.9Sex: Mrace: Caucasiandial_type: Conventional Haemo
64 GSM912824 WB_Uremia64 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 37.6Sex: Mrace: Caucasiandial_type: Pre Dialysis
65 GSM912825 WB_Uremia65 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 54.6Sex: Frace: Caucasiandial_type: CAPD
66 GSM912826 WB_Uremia66 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 46.6Sex: Mrace: Caucasiandial_type: Pre Dialysis
67 GSM912827 WB_Uremia67 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 45.4Sex: Frace: Caucasiandial_type: CCPD (Automated PD)
68 GSM912828 WB_Uremia68 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 58.4Sex: Mrace: Caucasiandial_type: CAPD
69 GSM912829 WB_Uremia69 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 49.7Sex: Mrace: Caucasiandial_type: Conventional Haemo
70 GSM912830 WB_Uremia70 [discovery]disease state: uremiatissue: whole blood (WB)age_tx: 53.2Sex: Frace: Caucasiandial_type: Pre Dialysis
71 GSM912831 WB_Uremia71 [validation]disease state: uremiatissue: whole blood (WB)age_tx: 43.4Sex: Mrace: Caucasiandial_type: Conventional Haemo
72 GSM912832 WB_Uremia72 [validation]disease state: uremiatissue: whole blood (WB)age_tx: 50.2Sex: Mrace: Caucasiandial_type: CAPD
73 GSM912833 WB_Uremia73 [validation]disease state: uremiatissue: whole blood (WB)age_tx: 50.7Sex: Mrace: Caucasiandial_type: Home Haemo
74 GSM912834 WB_Uremia74 [validation]disease state: uremiatissue: whole blood (WB)age_tx: 20.3Sex: Frace: Caucasiandial_type: CAPD
75 GSM912835 WB_Uremia75 [validation]disease state: uremiatissue: whole blood (WB)age_tx: 71.8Sex: Frace: Caucasiandial_type: Conventional Haemo
Gene Information
Official Symbol
PIK3CA
Officical Full Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Primary Source
HGNC:8975
See related
MIM:171834 HPRD:01382
Chromosome Location
3q26.3
Gene Type
protein-coding
Also known as
CLOVE CWS5 MCAP MCM MCMTC PI3K p110-alpha
External Sources
GUDMAP
Experiment Description
Accession
RGED37171
Type
Microarray
Summary
Renal failure is characterized by important biological changes resulting in profound pleomorphic physiological effects termed “uremia”, whose molecular causation is not well understood. The data was used to study gene expression changes in uremia using whole genome microarray analysis of peripheral blood from subjects with end-stage renal failure (n=63) and healthy controls (n=20) to obtain insight into the molecular and biological causation of this syndrome. The study was conducted at the University of British Columbia and approved by the human ethics research board. A 3:1 case-control design was employed to compare gene expression in patients with chronic renal failure and healthy controls. Patients with stage 5 renal disease aged 18 to 75 years, who were clinically stable awaiting renal transplantation, were not receiving immunosuppressive medications, and who provided written informed consent were enrolled into the study. Patients were treated according to Canadian Guidelines for Chronic Kidney Disease (13). Normal controls of comparable age and gender to the patients who were screened to ensure freedom from known illness and medical therapy served as comparators.
Experiment Platform
Affymetrix Human Genome U133 Plus 2.0 Array [HG-U133_Plus_2]
Data Source
GSE37171