RB1
Expression Profiles in
Diabetic Nephropathy
Tool Box: Similarity Analysis
Select from the Gene Set
Biocarta Pathway
41bb pathway[18]
Ace2 pathway[14]
Ach pathway[17]
Actiny pathway[21]
Agpcr pathway[14]
Agr pathway[37]
Ahsp pathway[14]
Akap13 pathway[13]
Akap95 pathway[13]
Akapcentrosome pathway[16]
Akt pathway[23]
Alk pathway[38]
Ami pathway[21]
Arap pathway[19]
Arenrf2 pathway[14]
Arf pathway[18]
Asbcell pathway[13]
At1r pathway[37]
Atm pathway[21]
Atrbrca pathway[22]
Bad pathway[27]
Barr mapk pathway[13]
Barrestin pathway[11]
Barrestin src pathway[16]
Bcellsurvival pathway[17]
Bcr pathway[38]
Biopeptides pathway[46]
Blymphocyte pathway[12]
Cacam pathway[17]
Calcineurin pathway[22]
Cardiacegf pathway[19]
Carm er pathway[36]
Carm1 pathway[14]
Caspase pathway[24]
Cbl pathway[14]
Ccr3 pathway[24]
Ccr5 pathway[21]
Cd40 pathway[16]
Cdc42rac pathway[17]
Cdk5 pathway[12]
Cdmac pathway[17]
Cell2cell pathway[15]
Cellcycle pathway[24]
Ceramide pathway[23]
Cftr pathway[13]
Chemical pathway[23]
Chrebp2 pathway[43]
Ck1 pathway[18]
Classic pathway[15]
Comp pathway[20]
Creb pathway[28]
Csk pathway[25]
Ctcf pathway[24]
Ctl pathway[16]
Ctla4 pathway[22]
Cxcr4 pathway[25]
Cytokine pathway[23]
D4gdi pathway[14]
Dc pathway[23]
Death pathway[34]
Dnafragment pathway[11]
Dream pathway[15]
Ecm pathway[25]
Edg1 pathway[28]
Egf pathway[32]
Egfr smrte pathway[12]
Eif pathway[17]
Eif2 pathway[12]
Eif4 pathway[25]
Epha4 pathway[11]
Epo pathway[20]
Eponfkb pathway[12]
Erk pathway[29]
Erk5 pathway[19]
Eryth pathway[16]
Etc pathway[13]
Ets pathway[19]
Extrinsic pathway[14]
Fas pathway[31]
Fcer1 pathway[42]
Feeder pathway[10]
Fibrinolysis pathway[13]
Fmlp pathway[40]
Free pathway[11]
G1 pathway[29]
G2 pathway[25]
Gaba pathway[11]
Gata3 pathway[17]
Gcr pathway[23]
Gh pathway[29]
Gleevec pathway[24]
Glycolysis pathway[11]
Gpcr pathway[38]
Granulocytes pathway[15]
Gsk3 pathway[28]
Hcmv pathway[18]
Hdac pathway[33]
Her2 pathway[23]
Hif pathway[16]
Hivnef pathway[59]
Hsp27 pathway[16]
Igf1 pathway[22]
Igf1mtor pathway[21]
Igf1r pathway[24]
Il10 pathway[18]
Il12 pathway[24]
Il17 pathway[18]
Il1r pathway[34]
Il2 pathway[23]
Il22bp pathway[17]
Il2rb pathway[39]
Il3 pathway[16]
Il4 pathway[12]
Il5 pathway[11]
Il6 pathway[23]
Il7 pathway[18]
Inflam pathway[30]
Insulin pathway[23]
Integrin pathway[39]
Intrinsic pathway[24]
Keratinocyte pathway[47]
Kreb pathway[9]
Lair pathway[18]
Lectin pathway[13]
Leptin pathway[12]
Longevity pathway[16]
Lym pathway[12]
Mal pathway[20]
Mapk pathway[88]
Mcalpain pathway[26]
Mcm pathway[19]
Mef2d pathway[24]
Met pathway[38]
Mitochondria pathway[22]
Monocyte pathway[12]
Mpr pathway[35]
Mta3 pathway[20]
Mtor pathway[24]
Myosin pathway[32]
Ndkdynamin pathway[22]
Neurotransmitters pathway[7]
Nfat pathway[57]
Nfkb pathway[24]
Ngf pathway[19]
Nkcells pathway[21]
Nkt pathway[30]
No1 pathway[34]
No2il12 pathway[18]
Nos1 pathway[25]
Nthi pathway[25]
Nuclearrs pathway[16]
P27 pathway[14]
P35alzheimers pathway[12]
P38mapk pathway[41]
P53 pathway[17]
P53hypoxia pathway[24]
Par1 pathway[38]
Parkin pathway[14]
Pdgf pathway[33]
Pgc1a pathway[27]
Pitx2 pathway[16]
Plateletapp pathway[15]
Plce pathway[13]
Pml pathway[18]
Ppara pathway[59]
Proteasome pathway[29]
Ps1 pathway[15]
Ptc1 pathway[12]
Ptdins pathway[24]
Pten pathway[19]
Pyk2 pathway[32]
Rab pathway[13]
Rac1 pathway[24]
Raccycd pathway[27]
Rankl pathway[15]
Ranms pathway[11]
Rarrxr pathway[16]
Ras pathway[24]
Rb pathway[14]
Rela pathway[17]
Rho pathway[33]
Rna pathway[11]
Salmonella pathway[14]
Sars pathway[11]
Set pathway[12]
Shh pathway[17]
Skp2e2f pathway[11]
Sodd pathway[11]
Sppa pathway[23]
Spry pathway[19]
Srcrptp pathway[12]
Stathmin pathway[20]
Stem pathway[16]
Stress pathway[26]
Tall1 pathway[16]
Tcapoptosis pathway[12]
Tcr pathway[50]
Tcra pathway[14]
Tcytotoxic pathway[15]
Tel pathway[19]
Tff pathway[22]
Tgfb pathway[20]
Th1th2 pathway[20]
Thelper pathway[15]
Tid pathway[20]
Tnfr1 pathway[30]
Tnfr2 pathway[19]
Tob1 pathway[22]
Toll pathway[38]
Tpo pathway[25]
Trka pathway[13]
Ucalpain pathway[19]
Vdr pathway[13]
Vegf pathway[30]
Vip pathway[30]
Vitcb pathway[12]
Wnt pathway[27]
KEGG Pathway
Abc transporters[45]
Acute myeloid leukemia[61]
Adherens junction[76]
Adipocytokine signaling pathway[68]
Alanine aspartate and glutamate metabolism[33]
Aldosterone regulated sodium reabsorption[43]
Allograft rejection[39]
Alpha linolenic acid metabolism[20]
Alzheimers disease[170]
Amino sugar and nucleotide sugar metabolism[45]
Aminoacyl trna biosynthesis[42]
Amyotrophic lateral sclerosis als[54]
Antigen processing and presentation[90]
Apoptosis[89]
Arachidonic acid metabolism[59]
Arginine and proline metabolism[55]
Arrhythmogenic right ventricular cardiomyopathy arvc[77]
Ascorbate and aldarate metabolism[26]
Asthma[31]
Autoimmune thyroid disease[54]
Axon guidance[130]
B cell receptor signaling pathway[76]
Basal cell carcinoma[56]
Basal transcription factors[37]
Base excision repair[36]
Beta alanine metabolism[23]
Biosynthesis of unsaturated fatty acids[23]
Bladder cancer[43]
Butanoate metabolism[35]
Calcium signaling pathway[179]
Cardiac muscle contraction[81]
Cell adhesion molecules cams[135]
Cell cycle[129]
Chemokine signaling pathway[191]
Chronic myeloid leukemia[74]
Circadian rhythm mammal[14]
Citrate cycle tca cycle[33]
Colorectal cancer[63]
Complement and coagulation cascades[70]
Cysteine and methionine metabolism[35]
Cytokine cytokine receptor interaction[268]
Cytosolic dna sensing pathway[57]
Dilated cardiomyopathy[93]
Dna replication[37]
Dorso ventral axis formation[26]
Drug metabolism cytochrome p450[73]
Drug metabolism other enzymes[52]
Ecm receptor interaction[85]
Endocytosis[184]
Endometrial cancer[53]
Epithelial cell signaling in helicobacter pylori infection[69]
Erbb signaling pathway[88]
Ether lipid metabolism[34]
Fatty acid metabolism[43]
Fc epsilon ri signaling pathway[80]
Fc gamma r mediated phagocytosis[98]
Focal adhesion[202]
Folate biosynthesis[12]
Fructose and mannose metabolism[35]
Galactose metabolism[27]
Gap junction[91]
Glioma[66]
Glutathione metabolism[51]
Glycerolipid metabolism[50]
Glycerophospholipid metabolism[78]
Glycine serine and threonine metabolism[32]
Glycolysis gluconeogenesis[63]
Glycosaminoglycan biosynthesis chondroitin sulfate[23]
Glycosaminoglycan biosynthesis heparan sulfate[27]
Glycosaminoglycan biosynthesis keratan sulfate[16]
Glycosaminoglycan degradation[22]
Glycosphingolipid biosynthesis ganglio series[16]
Glycosphingolipid biosynthesis globo series[15]
Glycosphingolipid biosynthesis lacto and neolacto series[27]
Glycosylphosphatidylinositol gpi anchor biosynthesis[26]
Glyoxylate and dicarboxylate metabolism[17]
Gnrh signaling pathway[102]
Graft versus host disease[43]
Hedgehog signaling pathway[57]
Hematopoietic cell lineage[89]
Histidine metabolism[30]
Homologous recombination[29]
Huntingtons disease[186]
Hypertrophic cardiomyopathy hcm[86]
Inositol phosphate metabolism[55]
Insulin signaling pathway[138]
Intestinal immune network for iga production[49]
Jak stat signaling pathway[156]
Leishmania infection[73]
Leukocyte transendothelial migration[119]
Limonene and pinene degradation[11]
Linoleic acid metabolism[30]
Long term depression[71]
Long term potentiation[71]
Lysine degradation[45]
Lysosome[122]
Mapk signaling pathway[268]
Maturity onset diabetes of the young[26]
Melanogenesis[103]
Melanoma[72]
Metabolism of xenobiotics by cytochrome p450[71]
Mismatch repair[24]
Mtor signaling pathway[53]
N glycan biosynthesis[47]
Natural killer cell mediated cytotoxicity[138]
Neuroactive ligand receptor interaction[273]
Neurotrophin signaling pathway[127]
Nicotinate and nicotinamide metabolism[25]
Nitrogen metabolism[24]
Nod like receptor signaling pathway[63]
Non homologous end joining[15]
Non small cell lung cancer[55]
Notch signaling pathway[48]
Nucleotide excision repair[45]
O glycan biosynthesis[31]
Olfactory transduction[390]
One carbon pool by folate[18]
Oocyte meiosis[115]
Other glycan degradation[17]
Oxidative phosphorylation[136]
P53 signaling pathway[70]
Pancreatic cancer[71]
Pantothenate and coa biosynthesis[17]
Parkinsons disease[134]
Pathogenic escherichia coli infection[60]
Pathways in cancer[329]
Pentose and glucuronate interconversions[29]
Pentose phosphate pathway[28]
Peroxisome[79]
Phenylalanine metabolism[19]
Phosphatidylinositol signaling system[77]
Porphyrin and chlorophyll metabolism[42]
Ppar signaling pathway[70]
Primary bile acid biosynthesis[17]
Primary immunodeficiency[36]
Prion diseases[36]
Progesterone mediated oocyte maturation[87]
Propanoate metabolism[34]
Prostate cancer[90]
Proteasome[49]
Protein export[25]
Proximal tubule bicarbonate reclamation[24]
Purine metabolism[160]
Pyrimidine metabolism[99]
Pyruvate metabolism[41]
Regulation of actin cytoskeleton[217]
Regulation of autophagy[36]
Renal cell carcinoma[71]
Renin angiotensin system[18]
Retinol metabolism[65]
Riboflavin metabolism[17]
Ribosome[89]
Rig i like receptor signaling pathway[72]
Rna degradation[60]
Rna polymerase[30]
Selenoamino acid metabolism[27]
Small cell lung cancer[85]
Snare interactions in vesicular transport[39]
Sphingolipid metabolism[41]
Spliceosome[129]
Starch and sucrose metabolism[53]
Steroid biosynthesis[18]
Steroid hormone biosynthesis[56]
Sulfur metabolism[14]
Systemic lupus erythematosus[141]
T cell receptor signaling pathway[109]
Taste transduction[53]
Taurine and hypotaurine metabolism[11]
Terpenoid backbone biosynthesis[16]
Tgf beta signaling pathway[87]
Thyroid cancer[30]
Tight junction[135]
Toll like receptor signaling pathway[103]
Tryptophan metabolism[41]
Type i diabetes mellitus[45]
Type ii diabetes mellitus[48]
Tyrosine metabolism[43]
Ubiquitin mediated proteolysis[139]
Valine leucine and isoleucine biosynthesis[12]
Valine leucine and isoleucine degradation[45]
Vascular smooth muscle contraction[116]
Vasopressin regulated water reabsorption[45]
Vegf signaling pathway[77]
Vibrio cholerae infection[57]
Viral myocarditis[74]
Wnt signaling pathway[152]
Reactome Pathway
3 utr mediated translational regulation[177]
A tetrasaccharide linker sequence is required for gag synthesis[26]
Abacavir transport and metabolism[11]
Abc family proteins mediated transport[35]
Abca transporters in lipid homeostasis[19]
Abortive elongation of hiv1 transcript in the absence of tat[24]
Acetylcholine binding and downstream events[17]
Acetylcholine neurotransmitter release cycle[11]
Activated ampk stimulates fatty acid oxidation in muscle[20]
Activated notch1 transmits signal to the nucleus[28]
Activated point mutants of fgfr2[17]
Activated tak1 mediates p38 mapk activation[19]
Activated tlr4 signalling[94]
Activation of atr in response to replication stress[39]
Activation of bh3 only proteins[18]
Activation of chaperone genes by atf6 alpha[12]
Activation of chaperone genes by xbp1s[47]
Activation of chaperones by atf6 alpha[14]
Activation of genes by atf4[27]
Activation of irf3 irf7 mediated by tbk1 ikk epsilon[15]
Activation of kainate receptors upon glutamate binding[32]
Activation of nf kappab in b cells[65]
Activation of nmda receptor upon glutamate binding and postsynaptic events[38]
Activation of rac[15]
Activation of the ap1 family of transcription factors[11]
Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s[85]
Activation of the pre replicative complex[32]
Acyl chain remodelling of pc[23]
Acyl chain remodelling of pe[22]
Acyl chain remodelling of pg[17]
Acyl chain remodelling of pi[16]
Acyl chain remodelling of ps[16]
Adaptive immune system[540]
Adenylate cyclase activating pathway[11]
Adenylate cyclase inhibitory pathway[14]
Adherens junctions interactions[28]
Adp signalling through p2ry1[26]
Adp signalling through p2ry12[22]
Advanced glycosylation endproduct receptor signaling[14]
Akt phosphorylates targets in the cytosol[13]
Alpha linolenic acid ala metabolism[13]
Amine compound slc transporters[28]
Amine derived hormones[16]
Amine ligand binding receptors[39]
Amino acid and oligopeptide slc transporters[50]
Amino acid synthesis and interconversion transamination[18]
Amino acid transport across the plasma membrane[32]
Amyloids[84]
Androgen biosynthesis[11]
Antigen activates b cell receptor leading to generation of second messengers[30]
Antigen presentation folding assembly and peptide loading of class i mhc[22]
Antigen processing cross presentation[77]
Antigen processing ubiquitination proteasome degradation[213]
Antiviral mechanism by ifn stimulated genes[67]
Apc c cdc20 mediated degradation of cyclin b[27]
Apc c cdc20 mediated degradation of mitotic proteins[74]
Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1[73]
Apc cdc20 mediated degradation of nek2a[29]
Apobec3g mediated resistance to hiv1 infection[13]
Apoptosis[149]
Apoptosis induced dna fragmentation[14]
Apoptotic cleavage of cell adhesion proteins[13]
Apoptotic cleavage of cellular proteins[41]
Apoptotic execution phase[55]
Aquaporin mediated transport[52]
Arms mediated activation[18]
Asparagine n linked glycosylation[82]
Assembly of the pre replicative complex[66]
Association of licensing factors with the pre replicative complex[15]
Association of tric cct with target proteins during biosynthesis[28]
Autodegradation of cdh1 by cdh1 apc c[65]
Autodegradation of the e3 ubiquitin ligase cop1[52]
Axon guidance[252]
Base excision repair[20]
Base free sugar phosphate removal via the single nucleotide replacement pathway[11]
Basigin interactions[31]
Beta defensins[43]
Bile acid and bile salt metabolism[28]
Bile salt and organic anion slc transporters[12]
Binding and entry of hiv virion[11]
Biological oxidations[140]
Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein[30]
Bmal1 clock npas2 activates circadian expression[37]
Botulinum neurotoxicity[20]
Branched chain amino acid catabolism[18]
Ca dependent events[31]
Calnexin calreticulin cycle[12]
Caspase mediated cleavage of cytoskeletal proteins[14]
Cd28 co stimulation[33]
Cd28 dependent pi3k akt signaling[23]
Cd28 dependent vav1 pathway[12]
Cdc6 association with the orc origin complex[12]
Cdk mediated phosphorylation and removal of cdc6[49]
Cdt1 association with the cdc6 orc origin complex[57]
Cell cell communication[121]
Cell cell junction organization[57]
Cell cycle[422]
Cell cycle checkpoints[125]
Cell cycle mitotic[326]
Cell death signalling via nrage nrif and nade[61]
Cell extracellular matrix interactions[15]
Cell junction organization[79]
Cell surface interactions at the vascular wall[92]
Cgmp effects[20]
Chemokine receptors bind chemokines[58]
Cholesterol biosynthesis[25]
Chondroitin sulfate biosynthesis[22]
Chondroitin sulfate dermatan sulfate metabolism[50]
Chromosome maintenance[123]
Chylomicron mediated lipid transport[17]
Circadian clock[54]
Circadian repression of expression by rev erba[24]
Citric acid cycle tca cycle[27]
Class a1 rhodopsin like receptors[306]
Class b 2 secretin family receptors[89]
Class c 3 metabotropic glutamate pheromone receptors[16]
Class i mhc mediated antigen processing presentation[252]
Cleavage of growing transcript in the termination region [45]
Collagen formation[59]
Common pathway[15]
Complement cascade[33]
Conversion from apc c cdc20 to apc c cdh1 in late anaphase[23]
Copi mediated transport[11]
Costimulation by the cd28 family[64]
Creation of c4 and c2 activators[11]
Creb phosphorylation through the activation of camkii[16]
Creb phosphorylation through the activation of ras[28]
Crmps in sema3a signaling[15]
Cross presentation of soluble exogenous antigens endosomes[49]
Cs ds degradation[13]
Ctla4 inhibitory signaling[22]
Ctnnb1 phosphorylation cascade[17]
Cyclin a b1 associated events during g2 m transition[16]
Cyclin e associated events during g1 s transition [66]
Cytochrome p450 arranged by substrate type[52]
Cytokine signaling in immune system[271]
Cytosolic sulfonation of small molecules[15]
Cytosolic trna aminoacylation[25]
Dag and ip3 signaling[33]
Darpp 32 events[26]
Dcc mediated attractive signaling[14]
Deadenylation dependent mrna decay[49]
Deadenylation of mrna[23]
Defensins[52]
Degradation of the extracellular matrix[30]
Deposition of new cenpa containing nucleosomes at the centromere[65]
Destabilization of mrna by auf1 hnrnp d0[54]
Destabilization of mrna by brf1[18]
Destabilization of mrna by ksrp[18]
Destabilization of mrna by tristetraprolin ttp[18]
Developmental biology[397]
Diabetes pathways[134]
Digestion of dietary carbohydrate[13]
Dna repair[113]
Dna replication[193]
Dna strand elongation[31]
Dopamine neurotransmitter release cycle[12]
Double strand break repair[25]
Downregulation of erbb2 erbb3 signaling[13]
Downregulation of smad2 3 smad4 transcriptional activity[21]
Downregulation of tgf beta receptor signaling[24]
Downstream signal transduction[96]
Downstream signaling events of b cell receptor bcr[98]
Downstream signaling of activated fgfr[101]
Downstream tcr signaling[38]
Dscam interactions[12]
E2f enabled inhibition of pre replication complex formation[11]
E2f mediated regulation of dna replication[36]
Early phase of hiv life cycle[22]
Effects of pip2 hydrolysis[26]
Egfr downregulation[26]
Eicosanoid ligand binding receptors[17]
Elevation of cytosolic ca2 levels[11]
Elongation arrest and recovery[33]
Endogenous sterols[16]
Endosomal sorting complex required for transport escrt[28]
Endosomal vacuolar pathway[10]
Energy dependent regulation of mtor by lkb1 ampk[19]
Enos activation and regulation[21]
Er phagosome pathway[62]
Erk mapk targets[22]
Erks are inactivated[13]
Ethanol oxidation[11]
Extension of telomeres[28]
Extracellular matrix organization[88]
Extrinsic pathway for apoptosis[14]
Facilitative na independent glucose transporters[13]
Factors involved in megakaryocyte development and platelet production[133]
Fanconi anemia pathway[26]
Fatty acid triacylglycerol and ketone body metabolism[169]
Fatty acyl coa biosynthesis[19]
Fgfr ligand binding and activation[23]
Fgfr1 ligand binding and activation[15]
Fgfr2c ligand binding and activation[13]
Fgfr4 ligand binding and activation[13]
Formation of atp by chemiosmotic coupling[17]
Formation of fibrin clot clotting cascade[33]
Formation of incision complex in gg ner[24]
Formation of rna pol ii elongation complex [46]
Formation of the hiv1 early elongation complex[35]
Formation of the ternary complex and subsequently the 43s complex[75]
Formation of transcription coupled ner tc ner repair complex[31]
Formation of tubulin folding intermediates by cct tric[23]
Frs2 mediated cascade[37]
G alpha i signalling events[196]
G alpha q signalling events[185]
G alpha s signalling events[122]
G alpha z signalling events[45]
G alpha1213 signalling events[75]
G beta gamma signalling through pi3kgamma[26]
G beta gamma signalling through plc beta[21]
G protein activation[28]
G protein beta gamma signalling[29]
G0 and early g1[26]
G1 phase[39]
G1 s specific transcription[20]
G1 s transition[113]
G2 m checkpoints[46]
G2 m dna damage checkpoint[13]
Gab1 signalosome[39]
Gaba a receptor activation[13]
Gaba b receptor activation[39]
Gaba receptor activation[53]
Gaba synthesis release reuptake and degradation[18]
Gamma carboxylation transport and amino terminal cleavage of proteins[12]
Gap junction assembly[19]
Gap junction degradation[11]
Gap junction trafficking[28]
Gastrin creb signalling pathway via pkc and mapk[206]
Generation of second messenger molecules[28]
Generic transcription pathway[353]
Global genomic ner gg ner[36]
Glucagon signaling in metabolic regulation[35]
Glucagon type ligand receptors[34]
Gluconeogenesis[35]
Glucose metabolism[70]
Glucose transport[39]
Glucuronidation[19]
Glutamate neurotransmitter release cycle[16]
Glutathione conjugation[24]
Glycerophospholipid biosynthesis[83]
Glycogen breakdown glycogenolysis[19]
Glycolysis[30]
Glycoprotein hormones[13]
Glycosaminoglycan metabolism[112]
Glycosphingolipid metabolism[39]
Golgi associated vesicle biogenesis[54]
Gpcr downstream signaling[806]
Gpcr ligand binding[409]
Gpvi mediated activation cascade[32]
Grb2 events in erbb2 signaling[23]
Grb2 sos provides linkage to mapk signaling for intergrins [16]
Growth hormone receptor signaling[25]
Hdl mediated lipid transport[16]
Hemostasis[467]
Heparan sulfate heparin hs gag metabolism[53]
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors[14]
Hiv infection[208]
Hiv life cycle[126]
Homologous recombination repair of replication independent double strand breaks[18]
Hormone ligand binding receptors[11]
Hormone sensitive lipase hsl mediated triacylglycerol hydrolysis[14]
Host interactions of hiv factors[133]
Hs gag biosynthesis[32]
Hs gag degradation[21]
Hyaluronan metabolism[15]
Hyaluronan uptake and degradation[11]
Ikk complex recruitment mediated by rip1[11]
Il 2 signaling[42]
Il 3 5 and gm csf signaling[44]
Il 6 signaling[12]
Il 7 signaling[12]
Il receptor shc signaling[28]
Il1 signaling[40]
Immune system[934]
Immunoregulatory interactions between a lymphoid and a non lymphoid cell[71]
Incretin synthesis secretion and inactivation[23]
Inflammasomes[18]
Influenza life cycle[204]
Influenza viral rna transcription and replication[170]
Inhibition of insulin secretion by adrenaline noradrenaline[26]
Inhibition of replication initiation of damaged dna by rb1 e2f1[14]
Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components[25]
Inhibition of voltage gated ca2 channels via gbeta gamma subunits[26]
Initial triggering of complement[17]
Innate immune system[280]
Insulin receptor recycling[24]
Insulin receptor signalling cascade[88]
Insulin synthesis and processing[22]
Integration of energy metabolism[121]
Integration of provirus[17]
Integrin alphaiib beta3 signaling[28]
Integrin cell surface interactions[80]
Interaction between l1 and ankyrins[24]
Interactions of vpr with host cellular proteins[34]
Interferon alpha beta signaling[65]
Interferon gamma signaling[64]
Interferon signaling[160]
Intrinsic pathway[18]
Intrinsic pathway for apoptosis[31]
Inwardly rectifying k channels[32]
Ion channel transport[56]
Ion transport by p type atpases[35]
Ionotropic activity of kainate receptors[12]
Irak1 recruits ikk complex[11]
Irak2 mediated activation of tak1 complex upon tlr7 8 or 9 stimulation[10]
Iron uptake and transport[37]
Jnk c jun kinases phosphorylation and activation mediated by activated human tak1[17]
Keratan sulfate biosynthesis[27]
Keratan sulfate degradation[12]
Keratan sulfate keratin metabolism[31]
Kinesins[25]
L1cam interactions[87]
Lagging strand synthesis[20]
Late phase of hiv life cycle[105]
Latent infection of homo sapiens with mycobacterium tuberculosis[34]
Ligand gated ion channel transport[22]
Lipid digestion mobilization and transport[47]
Lipoprotein metabolism[29]
Loss of nlp from mitotic centrosomes[60]
Lysosome vesicle biogenesis[24]
M g1 transition[82]
Map kinase activation in tlr cascade[51]
Mapk targets nuclear events mediated by map kinases[31]
Meiosis[117]
Meiotic recombination[87]
Meiotic synapsis[74]
Membrane binding and targetting of gag proteins[11]
Membrane trafficking[130]
Metabolism of amino acids and derivatives[201]
Metabolism of carbohydrates[248]
Metabolism of lipids and lipoproteins[479]
Metabolism of mrna[285]
Metabolism of non coding rna[50]
Metabolism of nucleotides[73]
Metabolism of polyamines[16]
Metabolism of porphyrins[15]
Metabolism of proteins[519]
Metabolism of rna[331]
Metabolism of steroid hormones and vitamins a and d[36]
Metabolism of vitamins and cofactors[52]
Metal ion slc transporters[23]
Mhc class ii antigen presentation[92]
Microrna mirna biogenesis[24]
Mitochondrial fatty acid beta oxidation[15]
Mitochondrial protein import[59]
Mitochondrial trna aminoacylation[22]
Mitotic g1 g1 s phases[138]
Mitotic g2 g2 m phases[82]
Mitotic m m g1 phases[173]
Mitotic prometaphase[88]
Mrna 3 end processing[36]
Mrna capping[31]
Mrna decay by 3 to 5 exoribonuclease[12]
Mrna decay by 5 to 3 exoribonuclease[16]
Mrna processing[162]
Mrna splicing[112]
Mrna splicing minor pathway[46]
Mtorc1 mediated signalling[12]
Muscle contraction[49]
Myd88 mal cascade initiated on plasma membrane[84]
Myogenesis[29]
N glycan antennae elongation[15]
N glycan antennae elongation in the medial trans golgi[19]
N glycan trimming in the er and calnexin calreticulin cycle[14]
Na cl dependent neurotransmitter transporters[18]
Ncam signaling for neurite out growth[65]
Ncam1 interactions[40]
Nef mediated downregulation of mhc class i complex cell surface expression[11]
Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters[22]
Negative regulation of fgfr signaling[38]
Negative regulation of the pi3k akt network[10]
Negative regulators of rig i mda5 signaling[32]
Nep ns2 interacts with the cellular export machinery[28]
Nephrin interactions[21]
Netrin1 signaling[42]
Neuronal system[280]
Neurotransmitter receptor binding and downstream transmission in the postsynaptic cell[138]
Neurotransmitter release cycle[35]
Nfkb activation through fadd rip1 pathway mediated by caspase 8 and10[13]
Nfkb and map kinases activation mediated by tlr4 signaling repertoire[73]
Nfkb is activated and signals survival[12]
Ngf signalling via trka from the plasma membrane[138]
Nitric oxide stimulates guanylate cyclase[26]
Nod1 2 signaling pathway[31]
Nonsense mediated decay enhanced by the exon junction complex[177]
Norepinephrine neurotransmitter release cycle[11]
Notch hlh transcription pathway[14]
Notch1 intracellular domain regulates transcription[47]
Nrage signals death through jnk[44]
Nrif signals cell death from the nucleus[16]
Nuclear events kinase and transcription factor activation[25]
Nuclear receptor transcription pathway[50]
Nuclear signaling by erbb4[39]
Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways[47]
Nucleotide excision repair[52]
Nucleotide like purinergic receptors[17]
O linked glycosylation of mucins[60]
Olfactory signaling pathway[329]
Opioid signalling[79]
Opsins[11]
Orc1 removal from chromatin[68]
Organic cation anion zwitterion transport[14]
Other semaphorin interactions[16]
Oxygen dependent proline hydroxylation of hypoxia inducible factor alpha[19]
P130cas linkage to mapk signaling for integrins[16]
P2y receptors[13]
P38mapk events[14]
P53 dependent g1 dna damage response[58]
P53 independent g1 s dna damage checkpoint[52]
P75 ntr receptor mediated signalling[82]
P75ntr recruits signalling complexes[13]
P75ntr signals via nfkb[15]
Packaging of telomere ends[49]
Passive transport by aquaporins[12]
Pd1 signaling[19]
Pecam1 interactions[11]
Peptide chain elongation[154]
Peptide hormone biosynthesis[15]
Peptide ligand binding receptors[189]
Perk regulated gene expression[30]
Peroxisomal lipid metabolism[22]
Phase ii conjugation[71]
Phase1 functionalization of compounds[71]
Phospholipase c mediated cascade[55]
Phospholipid metabolism[199]
Phosphorylation of cd3 and tcr zeta chains[17]
Phosphorylation of the apc c[24]
Pi 3k cascade[57]
Pi metabolism[49]
Pi3k akt activation[39]
Pi3k cascade[72]
Pi3k events in erbb2 signaling[45]
Pi3k events in erbb4 signaling[39]
Pip3 activates akt signaling[30]
Pka mediated phosphorylation of creb[19]
Pkb mediated events[30]
Platelet activation signaling and aggregation[209]
Platelet adhesion to exposed collagen[13]
Platelet aggregation plug formation[37]
Platelet calcium homeostasis[19]
Platelet homeostasis[79]
Platelet sensitization by ldl[17]
Plc beta mediated events[44]
Pol switching[14]
Post chaperonin tubulin folding pathway[20]
Post nmda receptor activation events[34]
Post translational modification synthesis of gpi anchored proteins[27]
Post translational protein modification[189]
Potassium channels[99]
Ppara activates gene expression[105]
Pre notch expression and processing[45]
Pre notch processing in golgi[17]
Pre notch transcription and translation[30]
Prefoldin mediated transfer of substrate to cct tric[29]
Presynaptic nicotinic acetylcholine receptors[13]
Processing of capped intron containing pre mrna[141]
Processing of capped intronless pre mrna[24]
Processing of intronless pre mrnas[15]
Processive synthesis on the lagging strand[16]
Prolactin receptor signaling[15]
Prolonged erk activation events[20]
Prostacyclin signalling through prostacyclin receptor[20]
Prostanoid ligand receptors[11]
Protein folding[54]
Proteolytic cleavage of snare complex proteins[18]
Ptm gamma carboxylation hypusine formation and arylsulfatase activation[28]
Purine catabolism[11]
Purine metabolism[34]
Purine ribonucleoside monophosphate biosynthesis[12]
Purine salvage[14]
Pyrimidine catabolism[13]
Pyrimidine metabolism[25]
Pyruvate metabolism[20]
Pyruvate metabolism and citric acid tca cycle[49]
Raf map kinase cascade[11]
Rap1 signalling[18]
Ras activation uopn ca2 infux through nmda receptor[18]
Receptor ligand binding initiates the second proteolytic cleavage of notch receptor[13]
Recruitment of mitotic centrosome proteins and complexes[67]
Recruitment of numa to mitotic centrosomes[11]
Recycling of bile acids and salts[12]
Recycling pathway of l1[28]
Regulated proteolysis of p75ntr[11]
Regulation of ampk activity via lkb1[16]
Regulation of apoptosis[59]
Regulation of beta cell development[31]
Regulation of complement cascade[15]
Regulation of gene expression in beta cells[21]
Regulation of glucokinase by glucokinase regulatory protein[28]
Regulation of hypoxia inducible factor hif by oxygen[26]
Regulation of ifna signaling[25]
Regulation of ifng signaling[15]
Regulation of insulin like growth factor igf activity by insulin like growth factor binding proteins igfbps[17]
Regulation of insulin secretion[94]
Regulation of insulin secretion by acetylcholine[12]
Regulation of insulin secretion by glucagon like peptide1[44]
Regulation of kit signaling[18]
Regulation of mitotic cell cycle[86]
Regulation of mrna stability by proteins that bind au rich elements[85]
Regulation of ornithine decarboxylase odc[50]
Regulation of pyruvate dehydrogenase pdh complex[14]
Regulation of rheb gtpase activity by ampk[11]
Regulation of signaling by cbl[19]
Regulation of the fanconi anemia pathway[12]
Regulation of water balance by renal aquaporins[45]
Regulatory rna pathways[27]
Removal of the flap intermediate from the c strand[11]
Repair synthesis for gap filling by dna pol in tc ner[15]
Resolution of ap sites via the multiple nucleotide patch replacement pathway[18]
Resolution of ap sites via the single nucleotide replacement pathway[13]
Respiratory electron transport[80]
Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins [99]
Response to elevated platelet cytosolic ca2 [90]
Retrograde neurotrophin signalling[14]
Reversible hydration of carbon dioxide[13]
Rig i mda5 mediated induction of ifn alpha beta pathways[74]
Rip mediated nfkb activation via dai[19]
Rna pol i promoter opening[63]
Rna pol i rna pol iii and mitochondrial transcription[123]
Rna pol i transcription[90]
Rna pol i transcription initiation[26]
Rna pol i transcription termination[23]
Rna pol ii pre transcription events[62]
Rna pol ii transcription[106]
Rna pol ii transcription pre initiation and promoter opening[42]
Rna pol iii chain elongation[18]
Rna pol iii transcription[34]
Rna pol iii transcription initiation from type 2 promoter[24]
Rna pol iii transcription initiation from type 3 promoter[27]
Rna pol iii transcription termination[20]
Role of dcc in regulating apoptosis[11]
Role of second messengers in netrin1 signaling[12]
Rora activates circadian expression[25]
S phase[110]
Scf beta trcp mediated degradation of emi1[52]
Scfskp2 mediated degradation of p27 p21[57]
Sema3a pak dependent axon repulsion[16]
Sema3a plexin repulsion signaling by inhibiting integrin adhesion[14]
Sema4d in semaphorin signaling[33]
Sema4d induced cell migration and growth cone collapse[28]
Semaphorin interactions[69]
Serotonin receptors[13]
Shc mediated cascade[29]
Shc mediated signalling[16]
Shc related events[18]
Shc1 events in egfr signaling[16]
Shc1 events in erbb4 signaling[21]
Signal amplification[32]
Signal attenuation[15]
Signal regulatory protein sirp family interactions[13]
Signal transduction by l1[35]
Signaling by activated point mutants of fgfr1[12]
Signaling by bmp[24]
Signaling by constitutively active egfr[19]
Signaling by egfr in cancer[110]
Signaling by erbb2[102]
Signaling by erbb4[91]
Signaling by fgfr[113]
Signaling by fgfr in disease[128]
Signaling by fgfr mutants[45]
Signaling by fgfr1 fusion mutants[20]
Signaling by fgfr1 mutants[31]
Signaling by fgfr3 mutants[12]
Signaling by gpcr[921]
Signaling by hippo[23]
Signaling by ils[108]
Signaling by insulin receptor[109]
Signaling by nodal[19]
Signaling by notch[104]
Signaling by notch1[71]
Signaling by notch2[13]
Signaling by notch3[13]
Signaling by notch4[13]
Signaling by pdgf[123]
Signaling by rho gtpases[114]
Signaling by robo receptor[31]
Signaling by scf kit[79]
Signaling by tgf beta receptor complex[64]
Signaling by the b cell receptor bcr[127]
Signaling by wnt[66]
Signalling by ngf[218]
Signalling to erks[37]
Signalling to p38 via rit and rin[16]
Signalling to ras[28]
Slbp dependent processing of replication dependent histone pre mrnas[12]
Slc mediated transmembrane transport[242]
Smad2 smad3 smad4 heterotrimer regulates transcription[28]
Smooth muscle contraction[26]
Sos mediated signalling[15]
Sphingolipid de novo biosynthesis[32]
Sphingolipid metabolism[70]
Spry regulation of fgf signaling[15]
Srp dependent cotranslational protein targeting to membrane[180]
Steroid hormones[30]
Striated muscle contraction[28]
Sulfur amino acid metabolism[25]
Synthesis and interconversion of nucleotide di and triphosphates[20]
Synthesis of bile acids and bile salts[20]
Synthesis of bile acids and bile salts via 24 hydroxycholesterol[11]
Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol[16]
Synthesis of dna[93]
Synthesis of glycosylphosphatidylinositol gpi[18]
Synthesis of pa[28]
Synthesis of pc[19]
Synthesis of pe[12]
Synthesis of pips at the early endosome membrane[13]
Synthesis of pips at the golgi membrane[18]
Synthesis of pips at the late endosome membrane[11]
Synthesis of pips at the plasma membrane[32]
Synthesis of substrates in n glycan biosythesis[15]
Synthesis of very long chain fatty acyl coas[15]
Synthesis secretion and deacylation of ghrelin[17]
Synthesis secretion and inactivation of gip[15]
Synthesis secretion and inactivation of glp1[20]
Tak1 activates nfkb by phosphorylation and activation of ikks complex[24]
Tandem pore domain potassium channels[13]
Tca cycle and respiratory electron transport[142]
Tcr signaling[55]
Telomere maintenance[76]
Termination of o glycan biosynthesis[25]
Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation[14]
Tgf beta receptor signaling activates smads[27]
Tgf beta receptor signaling in emt epithelial to mesenchymal transition[17]
The activation of arylsulfatases[13]
The nlrp3 inflammasome[13]
The role of nef in hiv1 replication and disease pathogenesis[29]
Thrombin signalling through proteinase activated receptors pars[33]
Thromboxane signalling through tp receptor[24]
Tie2 signaling[18]
Tight junction interactions[30]
Toll receptor cascades[119]
Traf3 dependent irf activation pathway[15]
Traf6 mediated induction of nfkb and map kinases upon tlr7 8 or 9 activation[78]
Traf6 mediated induction of tak1 complex[15]
Traf6 mediated irf7 activation[31]
Traf6 mediated irf7 activation in tlr7 8 or 9 signaling[11]
Traf6 mediated nfkb activation[22]
Trafficking and processing of endosomal tlr[15]
Trafficking of ampa receptors[29]
Trafficking of glur2 containing ampa receptors[17]
Trans golgi network vesicle budding[61]
Transcription[211]
Transcription coupled ner tc ner[46]
Transcriptional activity of smad2 smad3 smad4 heterotrimer[39]
Transcriptional regulation of white adipocyte differentiation[73]
Transferrin endocytosis and recycling[26]
Translation[223]
Translocation of zap 70 to immunological synapse[15]
Transmembrane transport of small molecules[414]
Transmission across chemical synapses[187]
Transport of glucose and other sugars bile salts and organic acids metal ions and amine compounds[90]
Transport of inorganic cations anions and amino acids oligopeptides[95]
Transport of mature mrna derived from an intronless transcript[34]
Transport of mature transcript to cytoplasm[55]
Transport of organic anions[12]
Transport of ribonucleoproteins into the host nucleus[28]
Transport of vitamins nucleosides and related molecules[32]
Transport to the golgi and subsequent modification[34]
Trif mediated tlr3 signaling[75]
Triglyceride biosynthesis[39]
Trna aminoacylation[43]
Tryptophan catabolism[12]
Unblocking of nmda receptor glutamate binding and activation[16]
Unfolded protein response[81]
Unwinding of dna[12]
Vegf ligand receptor interactions[11]
Vif mediated degradation of apobec3g[53]
Viral messenger rna synthesis[15]
Vitamin b5 pantothenate metabolism[12]
Voltage gated potassium channels[44]
Xenobiotics[17]
Yap1 and wwtr1 taz stimulated gene expression[25]
Zinc transporters[16]
Compare
Sample Grouping
A
Control_18hrs
1
GSM507417
Control_18hrs_rep1
cell line: HK-2
2
GSM507418
Control_18hrs_rep2
cell line: HK-2
3
GSM507419
Control_18hrs_rep3
cell line: HK-2
B
Control_48hrs
1
GSM507414
Control_48hrs_rep1
cell line: HK-2
2
GSM507415
Control_48hrs_rep2
cell line: HK-2
3
GSM507416
Control_48hrs_rep3
cell line: HK-2
C
C-peptide_18hrs
1
GSM507426
C-peptide_18hrs_rep1
cell line: HK-2
2
GSM507427
C-peptide_18hrs_rep2
cell line: HK-2
3
GSM507428
C-peptide_18hrs_rep3
cell line: HK-2
D
TGF-beta_48hrs
1
GSM507420
TGF-beta_48hrs_rep1
cell line: HK-2
2
GSM507421
TGF-beta_48hrs_rep2
cell line: HK-2
3
GSM507422
TGF-beta_48hrs_rep3
cell line: HK-2
E
C-peptide_48hrs
1
GSM507423
C-peptide_48hrs_rep1
cell line: HK-2
2
GSM507424
C-peptide_48hrs_rep2
cell line: HK-2
3
GSM507425
C-peptide_48hrs_rep3
cell line: HK-2
F
TGF-beta_C-peptide_48hrs
1
GSM507429
TGF-beta_C-peptide_48hrs_rep1
cell line: HK-2
2
GSM507430
TGF-beta_C-peptide_48hrs_rep2
cell line: HK-2
3
GSM507431
TGF-beta_C-peptide_48hrs_rep3
cell line: HK-2
Gene Information
Official Symbol
RB1
Officical Full Name
retinoblastoma 1
Primary Source
HGNC:9884
See related
MIM:614041
Ensembl:ENSG00000139687
HPRD:01574
Vega:OTTHUMG00000016900
Chromosome Location
13q14.2
Gene Type
protein-coding
Also known as
OSRC RB p105-Rb pRb pp110
External Sources
GUDMAP
Experiment Description
Accession
RGED20247
Type
Microarray
Summary
Microarray analysis reveals up-regulation of retinoic acid and hepatocyte growth factor related signaling pathways by pro-insulin C-peptide in kidney proximal tubular cells: Antagonism of the pro-fibrotic effects of TGF-b1
Experiment Platform
Illumina HumanWG-6 v3.0 expression beadchip
Data Source
GSE20247