RGED RGED / Next Generation Sequencing of PKD2 mutant mice

Public on 2019-09-24

Description

Purpose: Determine the differential gene expression pattern between wildtype, Pkd2-KO and Pkd2-miR-214 KO mice; Methods: kidney mRNA profiles of Pkd2-KO and Pkd2-mir-214-KO mice was sequenced with N of 3 in each group; Results: 972 differentially expressed transcripts were identified between Pkd2-KO kidneys and Pkd2-miR-214-KO kidneys; Conclusion: Deletion of miR-214 promotes interstitial inflammation in mouse models of ADPKD

Overall Design

kidney mRNA profiles of Pkd2-KO and Pkd2-miR-214 KO were determined by polyA mRNA sequencing with an N=3 different biological replicates in each group

Curator

hy_li

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