Description
We investigated the effects of metformin treatment on polycystic kidney disease in a mouse model of Pkd1-deficiency.; Kidneys are harvested in postnatal day 63 after 28 days of intraperitoneal injection of metformin (150 mg/kg/day) or saline for control. Total RNA was extracted for microarray analysis. Gene expression profiles were different between treatment and control groups.
Overall Design
Kidney RNA samples from three mice treated with saline and three mice treated with metformin were compared using microarray analysis.
Curator
xm_li