RGED RGED / Vitamin C deficiency causes cell type-specific epigenetic reprogramming and acute tubular necrosis

Public on 2021-12-07

Description

The recently described roles of vitamin C as an epigenetic regulator playsa crucial role in normal physiological development and pathological conditions.However, the epigenetic regulatory role of vitamin C in renal homeostasis andpathogenesis remains largely unknown. We aim to reveal that vitamin C deficiency promoted acute tubular necrosis,and provide a potential mechanism for epigenetic therapy in preventing the progression of chronic kidney disease.

Overall Design

scRNA-seq, WGBS and MeRIP-seq profiles of wild type (WT) and Gulo-/- mice

Curator

yq_pan

Related studies