RGED RGED / Monocytes transition to monocyte-macrophages within the inflamed vasculature via CCR2 on monocytes and endothelial TNFR2

Public on 2022-02-14

Description

Our study reports that CCR2 dependent functional specialization of monocytes into immature macrophages occurs within the TNF-TNFR2 activated vasculature and establishes a chemokine-based autocrine, feed-forward loop that may aplify the inflammation and renal injury.

Overall Design

Nephrotoxic Nephritis induced in 10, eight week old WT mice. Different populations of monocytes were FACS sorted and cells were processed for bulk RNAseq

Curator

yq_pan

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