RGED RGED / Effect of global Caspase-1 (Casp1) knockout (KO) on kidney gene expression in an orthologous mouse model of polycystic kidney disease (PKD)

Public on 2022-07-11

Description

We examined the effects of global Caspase-1 KO on kidney gene expression in an orthologous mouse model of PKD, which carries a homozygous knockin missense mutation, Pkd1RC/RC , that matches a human disease allele, PKD1 p.R3277C (“RC”).

Overall Design

Comparative gene expression profiling analysis of RNA-seq data from kidneys of 6 month-old wild-type (C57BL/6J), RC, and RC-Casp1KO mice (4 animals in each group).

Curator

yq_pan

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